scholarly journals A Novel Murine Cytomegalovirus Vaccine Vector Protects againstMycobacterium tuberculosis

2014 ◽  
Vol 193 (5) ◽  
pp. 2306-2316 ◽  
Author(s):  
Peter C. L. Beverley ◽  
Zsolt Ruzsics ◽  
Ariann Hey ◽  
Claire Hutchings ◽  
Simone Boos ◽  
...  
Keyword(s):  
Vaccine Vector ◽  
Murine Cytomegalovirus ◽  
Cytomegalovirus Vaccine

Promoter control over foreign antigen expression in a murine cytomegalovirus vaccine vector

Vaccine ◽  
2010 ◽  
Vol 29 (1) ◽  
pp. 141-151 ◽  
Author(s):  
Paula T. Cunningham ◽  
Megan L. Lloyd ◽  
Nicole L. Harvey ◽  
Elizabeth Williams ◽  
Christopher M. Hardy ◽  
...  
Keyword(s):  
Antigen Expression ◽  
Vaccine Vector ◽  
Murine Cytomegalovirus ◽  
Foreign Antigen ◽  
Cytomegalovirus Vaccine

Viral vectored immunocontraception: Screening of multiple fertility antigens using murine cytomegalovirus as a vaccine vector

Vaccine ◽  
2007 ◽  
Vol 25 (4) ◽  
pp. 698-708 ◽  
Author(s):  
Alec J. Redwood ◽  
Nicole L. Harvey ◽  
Megan Lloyd ◽  
Malcolm A. Lawson ◽  
Christopher M. Hardy ◽  
...  
Keyword(s):  
Vaccine Vector ◽  
Murine Cytomegalovirus

scholarly journals Immune Protection by a Cytomegalovirus Vaccine Vector Expressing a Single Low-Avidity Epitope

2017 ◽  
Vol 199 (5) ◽  
pp. 1737-1747 ◽  
Author(s):  
Lisa Borkner ◽  
Katarzyna M. Sitnik ◽  
Iryna Dekhtiarenko ◽  
Ann-Kathrin Pulm ◽  
Ronny Tao ◽  
...  
Keyword(s):  
Vaccine Vector ◽  
Immune Protection ◽  
Cytomegalovirus Vaccine

scholarly journals Lessons from studies with murine cytomegalovirus that could lead to a safe live attenuated vaccine for human cytomegalovirus

2020 ◽  
Vol 2 (9) ◽  
Author(s):  
Clive Sweet
Keyword(s):  
Dna Replication ◽  
Human Cytomegalovirus ◽  
Murine Cytomegalovirus ◽  
Wild Type ◽  
Live Attenuated Vaccine ◽  
Attenuated Vaccine ◽  
Replication Fitness ◽  
Cytomegalovirus Vaccine

Studies with a murine cytomegalovirus mutant tsm5 suggested two possible approaches to producing a live attenuated human cytomegalovirus vaccine. One approach would be to use a combination of five to six mutants where an attenuating mutation in the gene of one mutant is compensated by the wild-type version in a second mutant, which in turn has a mutation in a different gene compensated by the wild-type version in a third mutant, etc. Important genes in this approach could include those involved in DNA replication. The importance of the carboxy terminase of the primase gene (M70/UL70) for its function suggested a second approach where some of the natural codons in this region could be substituted with synonymous non-preferred (minor) codons that would reduce the replication fitness of the mutant.

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