scholarly journals Exosomes Derived from Burkitt’s Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells

2014 ◽  
Vol 192 (12) ◽  
pp. 5852-5862 ◽  
Author(s):  
Cindy Gutzeit ◽  
Noemi Nagy ◽  
Maurizio Gentile ◽  
Katarina Lyberg ◽  
Janine Gumz ◽  
...  
Keyword(s):  
B Cells ◽  
Cell Lines ◽  
Class Switch Recombination ◽  
Burkitt’S Lymphoma ◽  
Lymphoma Cell ◽  
Burkitt's Lymphoma ◽  
Class Switch

scholarly journals Correction: Exosomes Derived from Burkitt’s Lymphoma Cell Lines Induce Proliferation, Differentiation, and Class-Switch Recombination in B Cells

2019 ◽  
Vol 203 (3) ◽  
pp. 769-770
Author(s):  
Cindy Gutzeit ◽  
Noemi Nagy ◽  
Maurizio Gentile ◽  
Katarina Lyberg ◽  
Janine Gumz ◽  
...  
Keyword(s):  
B Cells ◽  
Cell Lines ◽  
Class Switch Recombination ◽  
Burkitt’S Lymphoma ◽  
Lymphoma Cell ◽  
Burkitt's Lymphoma ◽  
Class Switch

scholarly journals DIFFERENTIAL EXPRESSION OF CD150/SLAMF1 IN NORMAL AND MALIGNANT B CELLS ON THE DIFFERENT STAGES OF MATURATION

2016 ◽  
Vol 38 (2) ◽  
pp. 101-107 ◽  
Author(s):  
I M Gordienko ◽  
L M Shlapatska ◽  
L M Kovalevska ◽  
S P Sidorenko
Keyword(s):  
B Cells ◽  
B Cell ◽  
Cell Line ◽  
Cell Lines ◽  
Hodgkin’S Lymphoma ◽  
Burkitt’S Lymphoma ◽  
Lymphoma Cell ◽  
Burkitt's Lymphoma ◽  
Hodgkin's Lymphoma ◽  
Mrna Levels

Background: Within B-cell lineage cell surface receptor CD150/SLAMF1 is broadly expressed starting from pre-B cells with upregulation toward plasma cells. However, expression of CD150 is rather limited on the surface of malignant B cells with the block of differentiation at the different stages of maturation. The aim of our work was to explore CD150 expression both on protein and mRNA levels with the emphasis on CD150 isoforms in malignant B-cell lines at the different stages of maturation in comparison with their normal B cell counterparts. Materials and Methods: Studies were performed on normal tonsillar B-cell subpopulations, Blymphoblastoid cell lines, malignant B-cell lines of different origin, including pre-B acute lymphoblastic leukemia, Burkitt’s lymphoma, Hodgkin’s lymphoma, and multiple myeloma. Protein CD150 expression was assessed by western blot analysis and the expression level of CD150 isoforms was evaluated using qRT-PCR. Results: Despite the similar CD150 expression both on mRNA and protein levels in normal B-cell subsets and B-lymphoblastoid cell lines, malignant B-cell lines demonstrated substantial heterogeneity in CD150 expression. Only Hodgkin’s lymphoma cell lines, Burkitt’s lymphoma cell lines BJAB and Raji, and also pre-B cell line BLIN-1 expressed CD150 protein. At the same time total CD150 and mCD150 mRNA was detected in all studied cell lines excluding pre-B cell line REH. The minor sCD150 isoform was found only in Hodgkin’s lymphoma cell lines and Burkitt’s lymphoma cell line Raji. The nCD150 isoform was broadly expressed in tested B cell lines with exception of REH and Daudi. Conclusion: Malignant Bcell lines at the different stages of maturation only partially resemble their normal counterparts by CD150 expression. In malignant B-cell lines, CD150 expression on mRNA level is much broader than on protein level. CD150 isoforms are differentially expressed in normal and malignant B cells with predominant expression of mCD150 isoform.

scholarly journals Smac mimetics and TRAIL cooperate to induce MLKL-dependent necroptosis in Burkitt's lymphoma cell lines

Neoplasia ◽  
2021 ◽  
Vol 23 (5) ◽  
pp. 539-550
Author(s):  
Annkathrin Koch ◽  
Birte Jeiler ◽  
Jens Roedig ◽  
Sjoerd J.L. van Wijk ◽  
Nadezda Dolgikh ◽  
...  
Keyword(s):  
Cell Lines ◽  
Burkitt’S Lymphoma ◽  
Lymphoma Cell ◽  
Burkitt's Lymphoma ◽  
Smac Mimetics

Burkitt's lymphoma cell lines reveal different degrees of tumorigenicity in nude mice

1988 ◽  
Vol 41 (1) ◽  
pp. 87-95 ◽  
Author(s):  
V. E. Gurtsevitch ◽  
G. T. O'Conor ◽  
G. M. Lenoir
Keyword(s):  
Cell Lines ◽  
Nude Mice ◽  
Burkitt’S Lymphoma ◽  
Lymphoma Cell ◽  
Burkitt's Lymphoma

scholarly journals p53 is frequently mutated in Burkitt's lymphoma cell lines.

1991 ◽  
Vol 10 (10) ◽  
pp. 2879-2887 ◽  
Author(s):  
P.J. Farrell ◽  
G.J. Allan ◽  
F. Shanahan ◽  
K.H. Vousden ◽  
T. Crook
Keyword(s):  
Cell Lines ◽  
Burkitt’S Lymphoma ◽  
Lymphoma Cell ◽  
Burkitt's Lymphoma
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