scholarly journals Functional Comparison of Engineered T Cells Carrying a Native TCR versus TCR-like Antibody–Based Chimeric Antigen Receptors Indicates Affinity/Avidity Thresholds

2014 ◽  
Vol 193 (11) ◽  
pp. 5733-5743 ◽  
Author(s):  
Ravit Oren ◽  
Moran Hod-Marco ◽  
Maya Haus-Cohen ◽  
Sharyn Thomas ◽  
Dan Blat ◽  
...  
Keyword(s):  
T Cells ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors ◽  
Engineered T Cells

scholarly journals Genetically engineered T cells for cancer immunotherapy

2019 ◽  
Vol 4 (1) ◽  
Author(s):  
Dan Li ◽  
Xue Li ◽  
Wei-Lin Zhou ◽  
Yong Huang ◽  
Xiao Liang ◽  
...  
Keyword(s):  
T Cells ◽  
Cancer Immunotherapy ◽  
Hematological Malignancies ◽  
Genetically Engineered ◽  
Immune Checkpoints ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors ◽  
Recognition Method ◽  
Engineered T Cells ◽  
Mutant Cells

Abstract T cells in the immune system protect the human body from infection by pathogens and clear mutant cells through specific recognition by T cell receptors (TCRs). Cancer immunotherapy, by relying on this basic recognition method, boosts the antitumor efficacy of T cells by unleashing the inhibition of immune checkpoints and expands adaptive immunity by facilitating the adoptive transfer of genetically engineered T cells. T cells genetically equipped with chimeric antigen receptors (CARs) or TCRs have shown remarkable effectiveness in treating some hematological malignancies, although the efficacy of engineered T cells in treating solid tumors is far from satisfactory. In this review, we summarize the development of genetically engineered T cells, outline the most recent studies investigating genetically engineered T cells for cancer immunotherapy, and discuss strategies for improving the performance of these T cells in fighting cancers.

scholarly journals Chimeric Antigen Receptor-Engineered T Cells for Immunotherapy of Cancer

2010 ◽  
Vol 2010 ◽  
pp. 1-13 ◽  
Author(s):  
Marc Cartellieri ◽  
Michael Bachmann ◽  
Anja Feldmann ◽  
Claudia Bippes ◽  
Slava Stamova ◽  
...  
Keyword(s):  
T Cells ◽  
First Generation ◽  
Specific Immunotherapy ◽  
Third Generation ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors ◽  
Tumor Patients ◽  
Engineered T Cells ◽  
Clinical Responses ◽  
Immunotherapy Of Cancer

CD4+andCD8+T lymphocytes are powerful components of adaptive immunity, which essentially contribute to the elimination of tumors. Due to their cytotoxic capacity, T cells emerged as attractive candidates for specific immunotherapy of cancer. A promising approach is the genetic modification of T cells with chimeric antigen receptors (CARs). First generation CARs consist of a binding moiety specifically recognizing a tumor cell surface antigen and a lymphocyte activating signaling chain. The CAR-mediated recognition induces cytokine production and tumor-directed cytotoxicity of T cells. Second and third generation CARs include signal sequences from various costimulatory molecules resulting in enhanced T-cell persistence and sustained antitumor reaction. Clinical trials revealed that the adoptive transfer of T cells engineered with first generation CARs represents a feasible concept for the induction of clinical responses in some tumor patients. However, further improvement is required, which may be achieved by second or third generation CAR-engrafted T cells.

scholarly journals Tolerance and efficacy of autologous or donor-derived T cells expressing CD19 chimeric antigen receptors in adult B-ALL with extramedullary leukemia

2015 ◽  
Vol 4 (11) ◽  
pp. e1027469 ◽  
Author(s):  
Hanren Dai ◽  
Wenying Zhang ◽  
Xiaolei Li ◽  
Qingwang Han ◽  
Yelei Guo ◽  
...  
Keyword(s):  
T Cells ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors

Genetic engineering of T cells with chimeric antigen receptors for hematological malignancy immunotherapy

2018 ◽  
Vol 61 (11) ◽  
pp. 1320-1332 ◽  
Author(s):  
Dongdong Ti ◽  
Yunfei Niu ◽  
Zhiqiang Wu ◽  
Xiaobing Fu ◽  
Weidong Han
Keyword(s):  
T Cells ◽  
Genetic Engineering ◽  
Hematological Malignancy ◽  
Antigen Receptors ◽  
Chimeric Antigen Receptors
Sign in / Sign up

Export Citation Format

Share Document