scholarly journals CD24-Triggered Caspase-Dependent Apoptosis via Mitochondrial Membrane Depolarization and Reactive Oxygen Species Production of Human Neutrophils Is Impaired in Sepsis

2014 ◽  
Vol 192 (5) ◽  
pp. 2449-2459 ◽  
Author(s):  
Marianna Parlato ◽  
Fernando Souza-Fonseca-Guimaraes ◽  
François Philippart ◽  
Benoît Misset ◽  
Minou Adib-Conquy ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Mitochondrial Membrane ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Membrane Depolarization ◽  
Human Neutrophils ◽  
Oxygen Species ◽  
Mitochondrial Membrane Depolarization ◽  
Species Production

Effects of methoxylation of apocynin and analogs on the inhibition of reactive oxygen species production by stimulated human neutrophils

2001 ◽  
Vol 433 (2-3) ◽  
pp. 225-230 ◽  
Author(s):  
Edwin Van den Worm ◽  
Cees J Beukelman ◽  
Albert J.J Van den Berg ◽  
Burt H Kroes ◽  
Rudi P Labadie ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Human Neutrophils ◽  
Oxygen Species ◽  
Species Production

scholarly journals The effects of berberine on reactive oxygen species production in human neutrophils and in cell-free assays

2017 ◽  
Vol 10 (2) ◽  
pp. 61-65 ◽  
Author(s):  
Rami B. Kassab ◽  
Ondrej Vasicek ◽  
Milan Ciz ◽  
Antonin Lojek ◽  
Tomas Perecko
Keyword(s):  
Reactive Oxygen Species ◽  
Antioxidant Activity ◽  
Whole Blood ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Immune Defense ◽  
Peroxyl Radicals ◽  
Human Neutrophils ◽  
Oxygen Species ◽  
Species Production

AbstractThe health benefits of berberine have been recognized for years. Even so, its effects on human neutrophils, the first line of immune defense, have not been reported. The purpose of this study was to investigate the effects of berberine on the human neutrophil oxidative burst. Reactive oxygen species production was analyzed by luminol-enhanced chemiluminescence. The analysis was performed in spontaneous and stimulated (phorbol myristate acetate (PMA) or opsonized zymosan particles (OZP)) whole blood and isolated neutrophils in the presence or absence of berberine. The effects of berberine on oxidant production in cell-free assays were evaluated using luminescence (H2O2-peroxidase-luminol) and fluorescence (Oxygen Radical Absorbance Capacity – ORAC) techniques. Berberine decreased the production of reactive oxygen species in human whole blood and isolated neutrophils stimulated with either PMA or OZP with a different efficiency (EC50was 69 μM and 197 μM for PMA and OZP, respectively). The effect was more pronounced in isolated neutrophils. Cell-free assays showed the antioxidant activity of berberine against peroxyl radicals and hydrogen peroxide. Based on our results, we suggest that the effects of berberine on reactive oxygen species production in human neutrophils are due to its antioxidant activity.

scholarly journals β-Glucan Induces Reactive Oxygen Species Production in Human Neutrophils to Improve the Killing of Candida albicans and Candida glabrata Isolates from Vulvovaginal Candidiasis

PLoS ONE ◽  
2014 ◽  
Vol 9 (9) ◽  
pp. e107805 ◽  
Author(s):  
Patricia de Souza Bonfim-Mendonça ◽  
Bianca Altrão Ratti ◽  
Janine da Silva Ribeiro Godoy ◽  
Melyssa Negri ◽  
Nayara Cristina Alves de Lima ◽  
...  
Keyword(s):  
Reactive Oxygen Species ◽  
Candida Albicans ◽  
Candida Glabrata ◽  
Reactive Oxygen Species Production ◽  
Reactive Oxygen ◽  
Vulvovaginal Candidiasis ◽  
Human Neutrophils ◽  
Oxygen Species ◽  
Species Production
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