scholarly journals Signaling Pathways That Regulate T Cell Development and Differentiation

2012 ◽  
Vol 189 (12) ◽  
pp. 5487-5488 ◽  
Author(s):  
Leslie J. Berg
Keyword(s):  
T Cell ◽  
Signaling Pathways ◽  
T Cell Development ◽  
Cell Development ◽  
Development And Differentiation

scholarly journals MicroRNA-155 Controls iNKT Cell Development and Lineage Differentiation by Coordinating Multiple Regulating Pathways

2021 ◽  
Vol 8 ◽  
Author(s):  
Jie Wang ◽  
Kai Li ◽  
Xilin Zhang ◽  
Guihua Li ◽  
Tingting Liu ◽  
...  
Keyword(s):  
T Cell ◽  
Signaling Pathways ◽  
T Cell Development ◽  
Cell Lineage ◽  
Cd8 T Cell ◽  
Nkt Cells ◽  
Cell Development ◽  
Nkt Cell ◽  
Cellular Processes ◽  
Lineage Differentiation

The development of invariant natural killer T (iNKT) cells requires a well-attuned set of transcription factors, but how these factors are regulated and coordinated remains poorly understood. MicroRNA-155 (miR-155) is a key regulator of numerous cellular processes that affects cell development and homeostasis. Here, we found that miR-155 was highly expressed in early iNKT cells upon thymic selection, and then its expression is gradually downregulated during iNKT cell development. However, the mice with miR-155 germline deletion had normal iNKT cell development. To address if downregulated miR-155 is required for iNKT cell development, we made a CD4Cre.miR-155 knock-in (KI) mouse model with miR-155 conditional overexpression in the T cell lineage. Upregulated miR-155 led to interruption of iNKT cell development, diminished iNKT17 and iNKT1 cells, augmented iNKT2 cells, and these defects were cell intrinsic. Furthermore, defective iNKT cells in miR-155KI mice resulted in the secondary innate-like CD8 T cell development. Mechanistically, miR-155 modulated multiple targets and signaling pathways to fine tune iNKT cell development. MiR-155 modulated Jarid2, a critical component of a histone modification complex, and Tab2, the upstream activation kinase complex component of NF-κB, which function additively in iNKT development and in promoting balanced iNKT1/iNKT2 differentiation. In addition, miR-155 also targeted Rictor, a signature component of mTORC2 that controls iNKT17 differentiation. Taken together, our results indicate that miR-155 serves as a key epigenetic regulator, coordinating multiple signaling pathways and transcriptional programs to precisely regulate iNKT cell development and functional lineage, as well as secondary innate CD8 T cell development.

scholarly journals The Effects of TLR Activation on T-Cell Development and Differentiation

2012 ◽  
Vol 2012 ◽  
pp. 1-32 ◽  
Author(s):  
Bo Jin ◽  
Tao Sun ◽  
Xiao-Hong Yu ◽  
Ying-Xiang Yang ◽  
Anthony E. T. Yeo
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
T Cell Development ◽  
Cell Receptor ◽  
Treg Cells ◽  
Cell Development ◽  
T Cell Subsets ◽  
Follicular Helper ◽  
Development And Differentiation

Invading pathogens have unique molecular signatures that are recognized by Toll-like receptors (TLRs) resulting in either activation of antigen-presenting cells (APCs) and/or costimulation of T cells inducing both innate and adaptive immunity. TLRs are also involved in T-cell development and can reprogram Treg cells to become helper cells. T cells consist of various subsets, that is, Th1, Th2, Th17, T follicular helper (Tfh), cytotoxic T lymphocytes (CTLs), regulatory T cells (Treg) and these originate from thymic progenitor thymocytes. T-cell receptor (TCR) activation in distinct T-cell subsets with different TLRs results in differing outcomes, for example, activation of TLR4 expressed in T cells promotes suppressive function of regulatory T cells (Treg), while activation of TLR6 expressed in T cells abrogates Treg function. The current state of knowledge of regarding TLR-mediated T-cell development and differentiation is reviewed.

scholarly journals β-Catenin/TCF-1 Pathway in T Cell Development and Differentiation

2012 ◽  
Vol 7 (4) ◽  
pp. 750-762 ◽  
Author(s):  
Jian Ma ◽  
Ruiqing Wang ◽  
Xianfeng Fang ◽  
Zuoming Sun
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Development And Differentiation

scholarly journals Dissecting the dynamic changes of 5-hydroxymethylcytosine in T-cell development and differentiation

2014 ◽  
Vol 111 (32) ◽  
pp. E3306-E3315 ◽  
Author(s):  
A. Tsagaratou ◽  
T. Aijo ◽  
C.-W. J. Lio ◽  
X. Yue ◽  
Y. Huang ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Cell Development ◽  
Dynamic Changes ◽  
Development And Differentiation

scholarly journals Expression and regulation of intergenic long noncoding RNAs during T cell development and differentiation

2013 ◽  
Vol 14 (11) ◽  
pp. 1190-1198 ◽  
Author(s):  
Gangqing Hu ◽  
Qingsong Tang ◽  
Suveena Sharma ◽  
Fang Yu ◽  
Thelma M Escobar ◽  
...  
Keyword(s):  
T Cell ◽  
T Cell Development ◽  
Noncoding Rnas ◽  
Cell Development ◽  
Long Noncoding Rnas ◽  
Development And Differentiation
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