scholarly journals Ganglioside Inhibition of CD8+T Cell Cytotoxicity: Interference with Lytic Granule Trafficking and Exocytosis

2012 ◽  
Vol 189 (7) ◽  
pp. 3521-3527 ◽  
Author(s):  
Hee Chul Lee ◽  
Assefa Wondimu ◽  
Yihui Liu ◽  
Jennifer S. Y. Ma ◽  
Saša Radoja ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cell Cytotoxicity ◽  
Lytic Granule ◽  
T Cell Cytotoxicity

scholarly journals A novel co-culture assay to assess anti-tumor CD8+ T cell cytotoxicity via luminescence and multicolor flow cytometry

2020 ◽  
Vol 487 ◽  
pp. 112899
Author(s):  
Verónica Olivo Pimentel ◽  
Ala Yaromina ◽  
Damiënne Marcus ◽  
Ludwig J. Dubois ◽  
Philippe Lambin
Keyword(s):  
Flow Cytometry ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cell Cytotoxicity ◽  
Multicolor Flow Cytometry ◽  
T Cell Cytotoxicity

scholarly journals Blood Gene Signatures of Chagas Cardiomyopathy With or Without Ventricular Dysfunction

2016 ◽  
Vol 215 (3) ◽  
pp. 387-395 ◽  
Author(s):  
Ludmila Rodrigues Pinto Ferreira ◽  
Frederico Moraes Ferreira ◽  
Helder Imoto Nakaya ◽  
Xutao Deng ◽  
Darlan da Silva Cândido ◽  
...  
Keyword(s):  
T Cell ◽  
Disease Progression ◽  
Chagas Disease ◽  
Latin American ◽  
Cd8 T Cell ◽  
Left Ventricular ◽  
Left Ventricular Ejection ◽  
Cell Cytotoxicity ◽  
Chagas Cardiomyopathy ◽  
T Cell Cytotoxicity

AbstractChagas disease, caused by the protozoan parasite Trypanosoma cruzi, affects 7 million people in Latin American areas of endemicity. About 30% of infected patients will develop chronic Chagas cardiomyopathy (CCC), an inflammatory cardiomyopathy characterized by hypertrophy, fibrosis, and myocarditis. Further studies are necessary to understand the molecular mechanisms of disease progression. Transcriptome analysis has been increasingly used to identify molecular changes associated with disease outcomes. We thus assessed the whole-blood transcriptome of patients with Chagas disease. Microarray analysis was performed on blood samples from 150 subjects, of whom 30 were uninfected control patients and 120 had Chagas disease (1 group had asymptomatic disease, and 2 groups had CCC with either a preserved or reduced left ventricular ejection fraction [LVEF]). Each Chagas disease group displayed distinct gene expression and functional pathway profiles. The most different expression patterns were between CCC groups with a preserved or reduced LVEF. A more stringent analysis indicated that 27 differentially expressed genes, particularly those related to natural killer (NK)/CD8+ T-cell cytotoxicity, separated the 2 groups. NK/CD8+ T-cell cytotoxicity could play a role in determining Chagas disease progression. Understanding genes associated with disease may lead to improved insight into CCC pathogenesis and the identification of prognostic factors for CCC progression.

scholarly journals B Cell-Derived IL-15 Enhances CD8 T Cell Cytotoxicity and Is Increased in Multiple Sclerosis Patients

2011 ◽  
Vol 187 (8) ◽  
pp. 4119-4128 ◽  
Author(s):  
Raphael Schneider ◽  
Alma Nazlie Mohebiany ◽  
Igal Ifergan ◽  
Diane Beauseigle ◽  
Pierre Duquette ◽  
...  
Keyword(s):  
Multiple Sclerosis ◽  
T Cell ◽  
B Cell ◽  
Cd8 T Cell ◽  
Cell Cytotoxicity ◽  
Multiple Sclerosis Patients ◽  
T Cell Cytotoxicity

Murine CD8+T cell cytotoxicity against schistosomula induced by inoculation of schistosomal 22.6/26GST coupled Sepharose 4B beads

Vaccine ◽  
2012 ◽  
Vol 30 (14) ◽  
pp. 2440-2447 ◽  
Author(s):  
Ying Zhou ◽  
Hui Zhang ◽  
Xin-Juan Sun ◽  
Dan Zheng ◽  
Yue-Jin Liang ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cell Cytotoxicity ◽  
Sepharose 4B ◽  
T Cell Cytotoxicity

scholarly journals Induction of Potent CD8 T Cell Cytotoxicity by Specific Targeting of Antigen to Cross-Presenting Dendritic Cells In Vivo via Murine or Human XCR1

2014 ◽  
Vol 194 (3) ◽  
pp. 1069-1079 ◽  
Author(s):  
Evelyn Hartung ◽  
Martina Becker ◽  
Annabell Bachem ◽  
Nele Reeg ◽  
Anika Jäkel ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Cd8 T Cell ◽  
Cell Cytotoxicity ◽  
Specific Targeting ◽  
T Cell Cytotoxicity

scholarly journals Syntaxin 11 is required for NK and CD8+T-cell cytotoxicity and neutrophil degranulation

2012 ◽  
Vol 43 (1) ◽  
pp. 194-208 ◽  
Author(s):  
Orietta D'Orlando ◽  
Fang Zhao ◽  
Brigitte Kasper ◽  
Zane Orinska ◽  
Jürgen Müller ◽  
...  
Keyword(s):  
T Cell ◽  
Cd8 T Cell ◽  
Cell Cytotoxicity ◽  
Neutrophil Degranulation ◽  
Syntaxin 11 ◽  
T Cell Cytotoxicity

scholarly journals TCF-1 controls Treg cell functions that regulate inflammation, CD8+ T cell cytotoxicity and severity of colon cancer

2021 ◽  
Author(s):  
Abu Osman ◽  
Bingyu Yan ◽  
Ying Li ◽  
Kevin D. Pavelko ◽  
Jasmine Quandt ◽  
...  
Keyword(s):  
Colon Cancer ◽  
T Cell ◽  
Treg Cell ◽  
Cd8 T Cell ◽  
Cell Cytotoxicity ◽  
Cell Functions ◽  
T Cell Cytotoxicity
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