scholarly journals Environmental and T Cell–Intrinsic Factors Limit the Expansion of Neonatal Follicular T Helper Cells but May Be Circumvented by Specific Adjuvants

2012 ◽  
Vol 189 (12) ◽  
pp. 5764-5772 ◽  
Author(s):  
Béatris Mastelic ◽  
Arun T. Kamath ◽  
Paola Fontannaz ◽  
Chantal Tougne ◽  
Anne-Françoise Rochat ◽  
...  
Keyword(s):  
T Cell ◽  
T Helper Cells ◽  
T Helper ◽  
Intrinsic Factors ◽  
Helper Cells ◽  
Follicular T Helper Cells

Evaluation of follicular T-helper cells in primary cutaneous CD4+ small/medium pleomorphic T-cell lymphoma and dermatitis

2013 ◽  
Vol 40 (12) ◽  
pp. 1006-1013 ◽  
Author(s):  
Mina S. Ally ◽  
Ranganna Y. Prasad Hunasehally ◽  
Manuel Rodriguez-Justo ◽  
Blanca Martin ◽  
Roberto Verdolini ◽  
...  
Keyword(s):  
T Cell ◽  
T Helper Cells ◽  
Cell Lymphoma ◽  
T Cell Lymphoma ◽  
T Helper ◽  
Helper Cells ◽  
Follicular T Helper Cells

Balanced expression of CXCR5 and CCR7 on follicular T helper cells determines their transient positioning to lymph node follicles and is essential for efficient B-cell help

Blood ◽  
2005 ◽  
Vol 106 (6) ◽  
pp. 1924-1931 ◽  
Author(s):  
Svenja Hardtke ◽  
Lars Ohl ◽  
Reinhold Förster
Keyword(s):  
T Cells ◽  
T Cell ◽  
B Cells ◽  
B Cell ◽  
T Helper Cells ◽  
Cell Area ◽  
T Helper ◽  
Helper Cells ◽  
Follicular T Helper Cells ◽  
Cell Follicle

Abstract The production of high-affinity antibodies to T-dependent antigens requires the interaction of B cells and T helper cells expressing receptors specific for the same antigen. Although several mechanisms have been elucidated that regulate B-cell trafficking within lymphoid organs, less is known about molecular cues that guide the small subpopulation of CD4+ follicular T helper cells to B-cell follicles. Using adoptive transfer of transgenic T cells in mice, we demonstrate that antigen-induced activation leads to a finely tuned positioning of T cells either to the T-cell area or the B-cell follicle. We show that expression of CXCR5 is indispensable for T cells to enter B-cell follicles, whereas expression of CCR7 provides a counteracting signal to retain activated T cells in the T-cell area. Although only few T cells transiently migrate from the T-cell area to the B-cell follicle of peripheral lymph nodes following antigenic challenge, this step is essential to provide the help B cells require to produce antibodies efficiently. Thus, we demonstrate that the balanced expression of CCR7 and CXCR5 determines the positioning and proper function of follicular T helper cells.

scholarly journals Follicular T helper cells shape the HCV-specific CD4+ T cell repertoire after virus elimination

2020 ◽  
Vol 130 (2) ◽  
pp. 998-1009 ◽  
Author(s):  
Maike Smits ◽  
Katharina Zoldan ◽  
Naveed Ishaque ◽  
Zuguang Gu ◽  
Katharina Jechow ◽  
...  
Keyword(s):  
T Cell ◽  
T Helper Cells ◽  
Cd4 T Cell ◽  
T Cell Repertoire ◽  
T Helper ◽  
Cell Repertoire ◽  
Virus Elimination ◽  
Helper Cells ◽  
Follicular T Helper Cells

Type I Interferons promote maintenance and function of follicular T helper cells in vitro

2019 ◽  
Author(s):  
S Ehrlich ◽  
K Wild ◽  
M Smits ◽  
K Zoldan ◽  
M Hofmann ◽  
...  
Keyword(s):  
T Helper Cells ◽  
Type I Interferons ◽  
Type I ◽  
T Helper ◽  
Helper Cells ◽  
Follicular T Helper Cells ◽  
And Function
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