scholarly journals Differential Effects of Denileukin Diftitox IL-2 Immunotoxin on NK and Regulatory T Cells in Nonhuman Primates

2012 ◽  
Vol 188 (12) ◽  
pp. 6063-6070 ◽  
Author(s):  
Yohei Yamada ◽  
Akihiro Aoyama ◽  
Georges Tocco ◽  
Svjetlan Boskovic ◽  
Ognjenka Nadazdin ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Nonhuman Primates ◽  
Differential Effects ◽  
Denileukin Diftitox

scholarly journals Differential effects of α4β7 and GPR15 on homing of effector and regulatory T cells from patients with UC to the inflamed gut in vivo

Gut ◽  
2015 ◽  
Vol 65 (10) ◽  
pp. 1642-1664 ◽  
Author(s):  
Anika Fischer ◽  
Sebastian Zundler ◽  
Raja Atreya ◽  
Timo Rath ◽  
Caroline Voskens ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Differential Effects

Donor-lymphocyte infusion induces transplantation tolerance by activating systemic and graft-infiltrating double-negative regulatory T cells

Blood ◽  
2002 ◽  
Vol 100 (9) ◽  
pp. 3408-3414 ◽  
Author(s):  
Kevin J. Young ◽  
Liming Yang ◽  
M. James Phillips ◽  
Li Zhang
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Nonhuman Primates ◽  
Cell Receptor ◽  
Donor Lymphocyte Infusion ◽  
Transplantation Tolerance ◽  
Double Negative ◽  
Skin Grafts ◽  
Skin Allografts ◽  
Specific Tolerance

Abstract Donor-lymphocyte infusion (DLI) before transplantation can lead to specific tolerance to allografts in mice, nonhuman primates, and humans. We and others have demonstrated a role for regulatory T cells in DLI-induced, donor-specific transplantation tolerance, but it is not known how regulatory T cells are activated and where they execute their function. In this study, we observed, in both transgenic and normal mice, that DLI before transplantation is required for activation of αβ-T-cell-receptor–positive, CD3+CD4−CD8− double-negative (DN) regulatory T cells in the periphery of recipient mice. More interestingly, DLI induced DN regulatory T cells to migrate preferentially to donor-specific allogeneic skin grafts and to form a majority of graft-infiltrating T cells in accepted skin allografts. Furthermore, both recipient-derived peripheral and graft-infiltrating DN T cells were able to suppress and kill antidonor CD8+ T cells in an antigen-specific manner. These data indicate that DLI may induce donor-specific transplantation tolerance by activating recipient DN regulatory T cells in the periphery and by promoting migration of regulatory T cells to donor-specific allogeneic skin grafts. Our results also show that DN regulatory T cells can eliminate antidonor T cells both systemically and locally, a finding suggesting that graft-infiltrating T cells can be beneficial to graft survival.

scholarly journals Differential effects of inhibitors of the PI3K/mTOR pathway on the expansion and functionality of regulatory T cells

2016 ◽  
Vol 168 ◽  
pp. 47-54 ◽  
Author(s):  
Charlotte M. Huijts ◽  
Saskia J. Santegoets ◽  
Maria Quiles del Rey ◽  
Richard R. de Haas ◽  
Henk M. Verheul ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Mtor Pathway ◽  
Differential Effects

F.28. Treatment-Induced Immuneregulation in Arthritis: Differential Effects of Anti-TNFα and Methotrexate On Regulatory T-Cells

2006 ◽  
Vol 119 ◽  
pp. S60
Author(s):  
Sebastiaan Vastert ◽  
Astrid Van der Meer ◽  
Isme De Kleer ◽  
Mark Klein ◽  
Wietse Kuis ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Differential Effects

scholarly journals IL-27 controls the development of inducible regulatory T cells and Th17 cells via differential effects on STAT1

2007 ◽  
Vol 37 (7) ◽  
pp. 1809-1816 ◽  
Author(s):  
Clemens Neufert ◽  
Christoph Becker ◽  
Stefan Wirtz ◽  
Massimo C. Fantini ◽  
Benno Weigmann ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Th17 Cells ◽  
Differential Effects

Differential Effects of Calcineurin and Mammalian Target of Rapamycin Inhibitors on Alloreactive Th1, Th17, and Regulatory T Cells

2015 ◽  
Vol 99 (9) ◽  
pp. 1774-1784 ◽  
Author(s):  
Lorenzo Gallon ◽  
Opas Traitanon ◽  
Yuming Yu ◽  
Bo Shi ◽  
Joseph R. Leventhal ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Mammalian Target Of Rapamycin ◽  
Target Of Rapamycin ◽  
Differential Effects

scholarly journals Safety and immunologic effects of IL-15 administration in nonhuman primates

Blood ◽  
2009 ◽  
Vol 114 (12) ◽  
pp. 2417-2426 ◽  
Author(s):  
Carolina Berger ◽  
Michael Berger ◽  
Robert C. Hackman ◽  
Michael Gough ◽  
Carole Elliott ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
Regulatory T Cells ◽  
Nonhuman Primates ◽  
Interleukin 2 ◽  
Limited Data ◽  
Intermittent Administration ◽  
Cell Immunity ◽  
Cd8 T Cell Memory ◽  
Cd8 Memory T Cells

Abstract The administration of cytokines that modulate endogenous or transferred T-cell immunity could improve current approaches to clinical immunotherapy. Interleukin-2 (IL-2) is used most commonly for this purpose, but causes systemic toxicity and preferentially drives the expansion of CD4+CD25+Foxp3+ regulatory T cells, which can inhibit antitumor immunity. IL-15 belongs to the γc cytokine family and possesses similar properties to IL-2, including the ability to induce T-cell proliferation. Whereas IL-2 promotes apoptosis and limits the survival of CD8+ memory T cells, IL-15 is required for the establishment and maintenance of CD8+ T-cell memory. However, limited data are available to guide the clinical use of IL-15. Here, we demonstrate in nonhuman primates that IL-15 administration expands memory CD8+ and CD4+ T cells, and natural killer (NK) cells in the peripheral blood, with minimal increases in CD4+CD25+Foxp3+ regulatory T cells. Daily administration of IL-15 resulted in persistently elevated plasma IL-15 levels and transient toxicity. Intermittent administration of IL-15 allowed clearance of IL-15 between doses and was safe for more than 3 weeks. These findings demonstrate that IL-15 has profound immunomodulatory properties distinct from those described for IL-2, and suggest that intermittent administration of IL-15 should be considered in clinical studies.

Differential effects of regulatory T cells on the initiation and regression of atherosclerosis

2011 ◽  
Vol 218 (1) ◽  
pp. 53-60 ◽  
Author(s):  
A.C. Foks ◽  
V. Frodermann ◽  
M. ter Borg ◽  
K.L.L. Habets ◽  
I. Bot ◽  
...  
Keyword(s):  
T Cells ◽  
Regulatory T Cells ◽  
Differential Effects
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