scholarly journals Novel Humanized and Highly Efficient Bispecific Antibodies Mediate Killing of Prostate Stem Cell Antigen-Expressing Tumor Cells by CD8+and CD4+T Cells

2012 ◽  
Vol 189 (6) ◽  
pp. 3249-3259 ◽  
Author(s):  
Anja Feldmann ◽  
Claudia Arndt ◽  
Katrin Töpfer ◽  
Slava Stamova ◽  
Franziska Krone ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Tumor Cells ◽  
Cd4 T Cells ◽  
Bispecific Antibodies ◽  
Prostate Stem Cell Antigen ◽  
Cell Antigen ◽  
Highly Efficient

Retargeting of T cells to prostate stem cell antigen expressing tumor cells: Comparison of different antibody formats

The Prostate ◽  
2010 ◽  
Vol 71 (9) ◽  
pp. 998-1011 ◽  
Author(s):  
Anja Feldmann ◽  
Slava Stamova ◽  
Claudia C. Bippes ◽  
Holger Bartsch ◽  
Rebekka Wehner ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Tumor Cells ◽  
Prostate Stem Cell Antigen ◽  
Cell Antigen

Targeting of tumor cells expressing the prostate stem cell antigen (PSCA) using genetically engineered T-cells

The Prostate ◽  
2007 ◽  
Vol 67 (10) ◽  
pp. 1121-1131 ◽  
Author(s):  
Agnieszka Morgenroth ◽  
Marc Cartellieri ◽  
Marc Schmitz ◽  
Serap Günes ◽  
Bernd Weigle ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Tumor Cells ◽  
Genetically Engineered ◽  
Prostate Stem Cell Antigen ◽  
Cell Antigen ◽  
Engineered T Cells

Prostate stem cell antigen: Identification of immunogenic peptides and assessment of reactive CD8+T cells in prostate cancer patients

2002 ◽  
Vol 102 (4) ◽  
pp. 390-397 ◽  
Author(s):  
Andrea Kiessling ◽  
Marc Schmitz ◽  
Stefan Stevanovic ◽  
Bernd Weigle ◽  
Kristina Hölig ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
T Cells ◽  
Stem Cell ◽  
Cancer Patients ◽  
Cd8 T Cells ◽  
Prostate Stem Cell Antigen ◽  
Cell Antigen ◽  
Immunogenic Peptides

scholarly journals Stem Cell-Derived Viral Antigen-Specific T Cells Suppress HIV Replication and PD-1 Expression on CD4+ T Cells

Viruses ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 753
Author(s):  
Mohammad Haque ◽  
Fengyang Lei ◽  
Xiaofang Xiong ◽  
Yijie Ren ◽  
Hao-Yun Peng ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Adoptive Transfer ◽  
Cd4 T Cells ◽  
Viral Antigen ◽  
Peritoneal Macrophages ◽  
Hiv Replication ◽  
Specific Ctls ◽  
Immunodeficiency Virus ◽  
Hiv 1

The viral antigen (Ag)-specific CD8+ cytotoxic T lymphocytes (CTLs) derived from pluripotent stem cells (PSCs), i.e., PSC-CTLs, have the ability to suppress the human immunodeficiency virus (HIV) infection. After adoptive transfer, PSC-CTLs can infiltrate into the local tissues to suppress HIV replication. Nevertheless, the mechanisms by which the viral Ag-specific PSC-CTLs elicit the antiviral response remain to be fully elucidated. In this study, we generated the functional HIV-1 Gag epitope SL9-specific CTLs from the induced PSC (iPSCs), i.e., iPSC-CTLs, and investigated the suppression of SL9-specific iPSC-CTLs on viral replication and the protection of CD4+ T cells. A chimeric HIV-1, i.e., EcoHIV, was used to produce HIV replication in mice. We show that adoptive transfer of SL9-specific iPSC-CTLs greatly suppressed EcoHIV replication in the peritoneal macrophages and spleen in the animal model. Furthermore, we demonstrate that the adoptive transfer significantly reduced expression of PD-1 on CD4+ T cells in the spleen and generated persistent anti-HIV memory T cells. These results indicate that stem cell-derived viral Ag-specific CTLs can robustly accumulate in the local tissues to suppress HIV replication and prevent CD4+ T cell exhaustion through reduction of PD-1 expression.

scholarly journals IL-12p40 impairs mesenchymal stem cell-mediated bone regeneration via CD4+ T cells

2016 ◽  
Vol 23 (12) ◽  
pp. 1941-1951 ◽  
Author(s):  
Jiajia Xu ◽  
Yiyun Wang ◽  
Jing Li ◽  
Xudong Zhang ◽  
Yiyun Geng ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Bone Regeneration ◽  
Cd4 T Cells

scholarly journals Levels of CMV Specific CD4 T Cells Are Dynamic and Correlate with CMV Viremia after Allogeneic Stem Cell Transplantation

PLoS ONE ◽  
2008 ◽  
Vol 3 (11) ◽  
pp. e3634 ◽  
Author(s):  
Thomas Widmann ◽  
Urban Sester ◽  
Barbara C. Gärtner ◽  
Jörg Schubert ◽  
Michael Pfreundschuh ◽  
...  
Keyword(s):  
T Cells ◽  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cell Transplantation ◽  
Allogeneic Stem Cell Transplantation ◽  
Cd4 T Cells
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