scholarly journals Ileal Peyer’s Patches Are Not Necessary for Systemic B Cell Development and Maintenance and Do Not Contribute Significantly to the Overall B Cell Pool in Swine

2011 ◽  
Vol 187 (10) ◽  
pp. 5150-5161 ◽  
Author(s):  
Marek Sinkora ◽  
Katerina Stepanova ◽  
John E. Butler ◽  
David Francis ◽  
Kristina Santiago-Mateo ◽  
...  
Keyword(s):  
B Cell ◽  
Cell Development ◽  
B Cell Development ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Cell Pool

scholarly journals Two Distinct Pathways of B-Cell Development in Peyer’s Patches

1995 ◽  
Vol 4 (4) ◽  
pp. 263-277 ◽  
Author(s):  
Philip J. Griebel ◽  
Birgit Kugelberg ◽  
Giorgio Ferrari
Keyword(s):  
Cell Proliferation ◽  
B Cells ◽  
B Cell ◽  
Lymphoid Tissue ◽  
Day Treatment ◽  
Cell Development ◽  
B Cell Development ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Dexamethasone Treatment

The developmental biology of sheep ileal and jejunal Peyer’s patches (PP) was investigated using corticosteroids to deplete immature B lymphocytes. During a 7-day treatment with dexamethasone, ileal PP follicular (iPf)B-cell proliferation was arrested and most iPfB-cells died. This resulted in follicular involution with the survival of mesenchymal cells. No iPfB-cell proliferation was detected in follicular remnants for 4 weeks postdexamethasone treatment, and during a subsequent 3-month period, there was limited iPfB-cell proliferation that resulted in a partial regeneration of follicles. Ileal PP involution was also associated with a severe B lymphopenia that persisted for over 14 weeks and was characterized by the survival of primarily isotype-switched and CD5+sIgM+B-cells in blood. In contrast, the size of jejunal PP follicles was reduced following dexamethasone treatment, but intrafollicular B-cell proliferation was not arrested. Furthermore, within 4 weeks, the jejunal PP follicles had recovered in size and cellularity and there was no disruption in IgA plasma-cell production. Thus, dexamethasone selectively depleted iPfB-cells and revealed that the ileal and jejunal PPs contain functionally distinct B-cell populations. The partial regeneration of the iPfB-cell population indicated that either an intrafollicular, corticosteroid-resistant B-stem cell existed or that ileal PP follicles can be repopulated by circulating B-cells. Finally, the association between ileal PP involution and the absence of circulating, CD5-B-cells confirmed that this lymphoid tissue provides an essential environment for conventional sIgM+B-cell development.

scholarly journals The Effect of Dosage, Gestational Age and Splenectomy on Anti-IgM Interception of Prenatal B-cell Development in Sheep

2003 ◽  
Vol 10 (1) ◽  
pp. 19-26 ◽  
Author(s):  
P. McCullagh ◽  
C. McL. Press ◽  
S. J. McClure ◽  
H. J. Larsen ◽  
T. Landsverk
Keyword(s):  
Stem Cells ◽  
B Cells ◽  
B Cell ◽  
Cell Development ◽  
B Cell Development ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
B Cell Depletion ◽  
Limited Period ◽  
In Pregnancy

The administration of a single bolus of anti-IgM antibody to foetal lambs early in pregnancy produces prolonged B-cell depletion. The present study investigated this depletion by examining the effect, on B-cell development in the ileal Peyer's patches, of varying the timing and dosage of antibody administration and by supplementing anti-IgM with surgical splenectomy. The capacity of a 1 mg bolus of anti-IgM to deplete Peyer's patches of B cells was lost if its administration was deferred until two thirds of the way through pregnancy, but persisted beyond this time if weight-adjusted doses were used. Splenectomy of the foetus performed at an earlier age failed to extend the age at which a 1 mg dose of antibody remained effective. As the concentration of murine immunoglobulin in foetal serum was greatly reduced after 21 days, it is inferred that ongoing suppression of B-cell development is not dependent on the continued presence of murine immunoglobulin. The enduring nature of suppression could be attributable to a limited period during which differentiation of B cells from stem cells normally occurs, although further studies will be needed to investigate this and other possible explanations for the effect of anti-IgM treatment on prenatal B-cell development in sheep.

Fetal B cell development

1997 ◽  
Vol 56 (1-3) ◽  
pp. 98 ◽  
Author(s):  
J Kearney
Keyword(s):  
B Cell ◽  
Cell Development ◽  
B Cell Development

Genetic Control of DH Reading Frame and Its Effect on B-Cell Development and Antigen-Specifc Antibody Production

2010 ◽  
Vol 30 (4) ◽  
pp. 327-344 ◽  
Author(s):  
Harry W. Schroeder, Jr. ◽  
Michael Zemlin ◽  
Mohamed Khass ◽  
Huan H. Nguyen ◽  
Robert L. Schelonka
Keyword(s):  
B Cell ◽  
Genetic Control ◽  
Antibody Production ◽  
Cell Development ◽  
B Cell Development ◽  
Reading Frame
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