scholarly journals Antibody Repertoire Development in Fetal and Neonatal Piglets. XX. B Cell Lymphogenesis Is Absent in the Ileal Peyer’s Patches, Their Repertoire Development Is Antigen Dependent, and They Are Not Required for B Cell Maintenance

2011 ◽  
Vol 187 (10) ◽  
pp. 5141-5149 ◽  
Author(s):  
John E. Butler ◽  
Kristina Santiago-Mateo ◽  
Xiu-Zhu Sun ◽  
Nancy Wertz ◽  
Marek Sinkora ◽  
...  
Keyword(s):  
B Cell ◽  
Peyer's Patches ◽  
Antibody Repertoire ◽  
Peyer’S Patches ◽  
Neonatal Piglets ◽  
Repertoire Development ◽  
Cell Maintenance

scholarly journals Antibody Repertoire Development in Fetal and Neonatal Piglets. VI. B Cell Lymphogenesis Occurs at Multiple Sites with Differences in the Frequency of In-frame Rearrangements

2003 ◽  
Vol 170 (4) ◽  
pp. 1781-1788 ◽  
Author(s):  
Marek Šinkora ◽  
Jishan Sun ◽  
Jana Šinkorová ◽  
Ronald K. Christenson ◽  
Steven P. Ford ◽  
...  
Keyword(s):  
B Cell ◽  
Antibody Repertoire ◽  
Neonatal Piglets ◽  
Repertoire Development

scholarly journals Antibody repertoire development in fetal and neonatal piglets. XXII. λ rearrangement precedes κ rearrangement during B-cell lymphogenesis in swine

Immunology ◽  
2012 ◽  
Vol 137 (2) ◽  
pp. 149-159 ◽  
Author(s):  
Xiuzhu Sun ◽  
Nancy Wertz ◽  
Kelly Lager ◽  
Marek Sinkora ◽  
Katerina Stepanova ◽  
...  
Keyword(s):  
B Cell ◽  
Antibody Repertoire ◽  
Neonatal Piglets ◽  
Repertoire Development

Evidence for the existence of regulatory and effector B cell populations in Peyer’s patches of sheep

2016 ◽  
Vol 174 ◽  
pp. 26-34 ◽  
Author(s):  
S. Jimbo ◽  
P.J. Griebel ◽  
H. Townsend ◽  
L.A. Babiuk ◽  
G. Mutwiri
Keyword(s):  
B Cell ◽  
Peyer's Patches ◽  
Cell Populations ◽  
Peyer’S Patches

scholarly journals Two Distinct Pathways of B-Cell Development in Peyer’s Patches

1995 ◽  
Vol 4 (4) ◽  
pp. 263-277 ◽  
Author(s):  
Philip J. Griebel ◽  
Birgit Kugelberg ◽  
Giorgio Ferrari
Keyword(s):  
Cell Proliferation ◽  
B Cells ◽  
B Cell ◽  
Lymphoid Tissue ◽  
Day Treatment ◽  
Cell Development ◽  
B Cell Development ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Dexamethasone Treatment

The developmental biology of sheep ileal and jejunal Peyer’s patches (PP) was investigated using corticosteroids to deplete immature B lymphocytes. During a 7-day treatment with dexamethasone, ileal PP follicular (iPf)B-cell proliferation was arrested and most iPfB-cells died. This resulted in follicular involution with the survival of mesenchymal cells. No iPfB-cell proliferation was detected in follicular remnants for 4 weeks postdexamethasone treatment, and during a subsequent 3-month period, there was limited iPfB-cell proliferation that resulted in a partial regeneration of follicles. Ileal PP involution was also associated with a severe B lymphopenia that persisted for over 14 weeks and was characterized by the survival of primarily isotype-switched and CD5+sIgM+B-cells in blood. In contrast, the size of jejunal PP follicles was reduced following dexamethasone treatment, but intrafollicular B-cell proliferation was not arrested. Furthermore, within 4 weeks, the jejunal PP follicles had recovered in size and cellularity and there was no disruption in IgA plasma-cell production. Thus, dexamethasone selectively depleted iPfB-cells and revealed that the ileal and jejunal PPs contain functionally distinct B-cell populations. The partial regeneration of the iPfB-cell population indicated that either an intrafollicular, corticosteroid-resistant B-stem cell existed or that ileal PP follicles can be repopulated by circulating B-cells. Finally, the association between ileal PP involution and the absence of circulating, CD5-B-cells confirmed that this lymphoid tissue provides an essential environment for conventional sIgM+B-cell development.

Antibody repertoire development in fetal and neonatal piglets

2011 ◽  
Vol 49 (3) ◽  
pp. 483-494 ◽  
Author(s):  
John E. Butler ◽  
Xuizhu Sun ◽  
Nancy Wertz ◽  
Kelly M. Lager ◽  
Kathryn Chaloner ◽  
...  
Keyword(s):  
Antibody Repertoire ◽  
Neonatal Piglets ◽  
Repertoire Development

scholarly journals Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches

2002 ◽  
Vol 196 (1) ◽  
pp. 65-75 ◽  
Author(s):  
Takaharu Okada ◽  
Vu N. Ngo ◽  
Eric H. Ekland ◽  
Reinhold Förster ◽  
Martin Lipp ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
B Cell ◽  
Chemokine Receptor ◽  
Cell Entry ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Wild Type ◽  
High Endothelial Venules ◽  
Cell Homing ◽  
T Cell Homing

B cell entry to lymph nodes and Peyer's patches depends on chemokine receptor signaling, but the principal chemokine involved has not been defined. Here we show that the homing of CXCR4−/− B cells is suppressed in CCL19 (ELC)- and CCL21 (SLC)-deficient paucity of lymph node T cells mice, but not in wild-type mice. We also find that CXCR4 can contribute to T cell homing. Using intravital microscopy, we find that B cell adhesion to high endothelial venules (HEVs) is disrupted when CCR7 and CXCR4 are predesensitized. In Peyer's patches, B cell entry is dependent on CXCR5 in addition to CCR7/CXCR4. CXCL12 (SDF1) is displayed broadly on HEVs, whereas CXCL13 (BLC) is found selectively on Peyer's patch follicular HEVs. These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches.

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