scholarly journals Astrocytes, but Not Microglia, Rapidly Sense H2O2 via STAT6 Phosphorylation, Resulting in Cyclooxygenase-2 Expression and Prostaglandin Release

2012 ◽  
Vol 188 (10) ◽  
pp. 5132-5141 ◽  
Author(s):  
Soo Jung Park ◽  
Jee Hoon Lee ◽  
Hee Young Kim ◽  
Youn Hee Choi ◽  
Jung Sup Park ◽  
...  
Keyword(s):  
Cyclooxygenase 2 ◽  
Prostaglandin Release

scholarly journals Hypotonic Stress Increases Cyclooxygenase-2 Expression and Prostaglandin Release from Amnion-derived WISH Cells

1997 ◽  
Vol 272 (32) ◽  
pp. 20118-20124 ◽  
Author(s):  
David W. Lundgren ◽  
Robert M. Moore ◽  
Patricia L. Collins ◽  
John J. Moore
Keyword(s):  
Cyclooxygenase 2 ◽  
Hypotonic Stress ◽  
Prostaglandin Release

Maternal recognition of pregnancy in the horse: a mystery still to be solved

2011 ◽  
Vol 23 (8) ◽  
pp. 952 ◽  
Author(s):  
C. Klein ◽  
M. H. T. Troedsson
Keyword(s):  
Prostaglandin F2α ◽  
Cyclooxygenase 2 ◽  
Microarray Experiments ◽  
Luteal Function ◽  
Domestic Species ◽  
Prostaglandin Release ◽  
Conceptus Development ◽  
Immunological Rejection ◽  
Pregnancy Recognition ◽  
Maternal Recognition Of Pregnancy

Maternal recognition of pregnancy in the horse is the sum of events leading to maintenance of pregnancy; in a narrow sense, maternal recognition of pregnancy refers to the physiological process by which the lifespan of the corpus luteum is prolonged. The horse is one of the few domestic species in which the conceptus-derived pregnancy recognition signal has not been identified. The presence of the conceptus reduces pulsatile prostaglandin F2α secretion by the endometrium during early gestation in the mare, partly attributed to the reduced expression of cyclooxygenase-2. Cyclooxygenase-2 has therefore been suggested as one of the regulators of endometrial prostaglandin F2α release modified by the antiluteolytic factor secreted by the conceptus. In addition, altered oxytocin responsiveness has been implicated in the adjustment of prostaglandin release in pregnant mares. While conceptus mobility has proven to be essential for establishment of pregnancy, conceptus-derived oestrogens and prostaglandins, principally prostaglandin E2, have not been confirmed as the critical antiluteolytic factor. Various ways to induce prolonged luteal function in the non-pregnant mare will be highlighted in the current review, specifically, how they may pertain to the process of maternal recognition of pregnancy. Furthermore, recently published microarray experiments comparing the transcriptome of pregnant and non-pregnant endometria and different stages of conceptus development will be reviewed. Findings include the prevention of conceptus adhesion, the provision of nutrients to the conceptus and the avoidance of immunological rejection, among others.

Fluid shear stress induction of COX-2 protein and prostaglandin release in cultured MC3T3-E1 osteoblasts does not require intact microfilaments or microtubules

2004 ◽  
Vol 96 (3) ◽  
pp. 957-966 ◽  
Author(s):  
Suzanne M. Norvell ◽  
Suzanne M. Ponik ◽  
Deidre K. Bowen ◽  
Rita Gerard ◽  
Fredrick M. Pavalko
Keyword(s):  
Shear Stress ◽  
Intermediate Filaments ◽  
Fluid Shear Stress ◽  
Mechanical Stimulus ◽  
Cyclooxygenase 2 ◽  
Actin Microfilaments ◽  
Fluid Shear ◽  
Pharmacological Agents ◽  
Prostaglandin Release ◽  
Cytoskeletal Networks

Cultured osteoblasts express three major types of cytoskeleton: actin microfilaments, microtubules, and intermediate filaments. The cytoskeletal network is thought to play an important role in the transmission and conversion of a mechanical stimulus into a biochemical response. To examine a role for the three different cytoskeletal networks in fluid shear stress-induced signaling in osteoblasts, we individually disrupted actin microfilaments, micro-tubules, and intermediate filaments in MC3T3-E1 osteoblasts with multiple pharmacological agents. We subjected these cells to 90 min of laminar fluid shear stress (10 dyn/cm2) and compared the PGE2 and PGI2 release and induction of cyclooxygenase-2 protein to control cells with intact cytoskeletons. Disruption of actin microfilaments, microtubules, or intermediate filaments in MC3T3-E1 cells did not prevent a significant fluid shear stress-induced release of PGE2 or PGI2. Furthermore, disruption of actin microfilaments or microtubules did not prevent a significant fluid shear stress-induced increase in cyclooxygenase-2 protein levels. Disruption of intermediate filaments with acrylamide did prevent the fluid shear stress-induced increase in cyclooxygenase-2 but also prevented a PGE2-induced increase in cyclooxygenase-2. Thus none of the three major cytoskeletal networks are required for fluid shear stress-induced prostaglandin release. Furthermore, although neither actin microfilaments nor microtubules are required for fluid shear stress-induced increase in cyclooxygenase-2 levels, the role of intermediate filaments in regulation of cyclooxygenase-2 expression is less clear.

Contribution of stromal and epithelial cells to cyclooxygenase-2 (COX-2) activity in Barrett's esophagus

2001 ◽  
Vol 120 (5) ◽  
pp. A78-A79
Author(s):  
N BUTTAR ◽  
K WANG ◽  
M ANDERSON ◽  
L LUTZKE ◽  
K KRISHNADATH
Keyword(s):  
Epithelial Cells ◽  
Barrett’S Esophagus ◽  
Barrett's Esophagus ◽  
Cyclooxygenase 2 ◽  
Cox 2

Expressions of cyclooxygenase-2 (COX-2) and prostaglandin E receptors (EPs) in gallbladder carcinoma (GBca)-association with tumor progression

2001 ◽  
Vol 120 (5) ◽  
pp. A573-A573
Author(s):  
J SHODA ◽  
T ASANO ◽  
T KAWAMOTO ◽  
Y MATSUZAKI ◽  
N TANAKA ◽  
...  
Keyword(s):  
Tumor Progression ◽  
Gallbladder Carcinoma ◽  
Cyclooxygenase 2 ◽  
Prostaglandin E ◽  
Cox 2

Expression of survivin and its correlation with cyclooxygenase-2 in gastric cancer

2001 ◽  
Vol 120 (5) ◽  
pp. A496-A496
Author(s):  
J YU ◽  
W LEUNG ◽  
M EBERT ◽  
E NG ◽  
M GO ◽  
...  
Keyword(s):  
Gastric Cancer ◽  
Cyclooxygenase 2

Gastrin and cyclooxygenase-2 (COX-2) expression in Helicobacter pylori (Hp) infected gastric ulceration

2001 ◽  
Vol 120 (5) ◽  
pp. A727-A727
Author(s):  
S KONTUREK ◽  
P KONTUREK ◽  
W BIELANSKI ◽  
A DUDA ◽  
M ZUCHOWICZ ◽  
...  
Keyword(s):  
Helicobacter Pylori ◽  
Gastric Ulceration ◽  
Cyclooxygenase 2 ◽  
Cox 2

279: Inhibition of Cyclooxygenase-2 Pathway Overcomes the Heat-Resistance in Prostate Cancer Cells

2007 ◽  
Vol 177 (4S) ◽  
pp. 93-93
Author(s):  
Makoto Sumitomo ◽  
Kenji Kuroda ◽  
Takako Asano ◽  
Akio Horiguchi ◽  
Keiichi Ito ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Heat Resistance ◽  
Cancer Cells ◽  
Cyclooxygenase 2 ◽  
Prostate Cancer Cells
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