scholarly journals Cytosolic DNA-Activated Human Dendritic Cells Are Potent Activators of the Adaptive Immune Response

2011 ◽  
Vol 187 (3) ◽  
pp. 1222-1234 ◽  
Author(s):  
Katalin Kis-Toth ◽  
Attila Szanto ◽  
To-Ha Thai ◽  
George C. Tsokos
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Human Dendritic Cells

scholarly journals CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response

2008 ◽  
Vol 38 (4) ◽  
pp. 1024-1032 ◽  
Author(s):  
Undine Lippert ◽  
Karolin Zachmann ◽  
David M. Ferrari ◽  
Herbert Schwarz ◽  
Edgar Brunner ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Adaptive Immune Response ◽  
Multiple Functions ◽  
Reverse Signaling ◽  
Adaptive Immune ◽  
Human Dendritic Cells

Correction: CD137 ligand reverse signaling has multiple functions in human dendritic cells during an adaptive immune response

2008 ◽  
Vol 38 (6) ◽  
pp. 1767-1767
Author(s):  
Undine Lippert ◽  
Karolin Zachmann ◽  
David M. Ferrari ◽  
Herbert Schwarz ◽  
Edgar Brunner ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Adaptive Immune Response ◽  
Multiple Functions ◽  
Reverse Signaling ◽  
Adaptive Immune ◽  
Human Dendritic Cells

scholarly journals Effects of Staphylococcus aureus Bacteriophage K on Expression of Cytokines and Activation Markers by Human Dendritic Cells In Vitro

Viruses ◽  
2018 ◽  
Vol 10 (11) ◽  
pp. 617 ◽  
Author(s):  
Helen Freyberger ◽  
Yunxiu He ◽  
Amanda Roth ◽  
Mikeljon Nikolich ◽  
Andrey Filippov
Keyword(s):  
Staphylococcus Aureus ◽  
Dendritic Cells ◽  
Inflammatory Response ◽  
Adaptive Immune Response ◽  
Human Monocyte ◽  
Activation Markers ◽  
Mhc I ◽  
Adaptive Immune ◽  
Human Dendritic Cells

A potential concern with bacteriophage (phage) therapeutics is a host-versus-phage response in which the immune system may neutralize or destroy phage particles and thus impair therapeutic efficacy, or a strong inflammatory response to repeated phage exposure might endanger the patient. Current literature is discrepant with regard to the nature and magnitude of innate and adaptive immune response to phages. The purpose of this work was to study the potential effects of Staphylococcus aureus phage K on the activation of human monocyte-derived dendritic cells. Since phage K acquired from ATCC was isolated around 90 years ago, we first tested its activity against a panel of 36 diverse S. aureus clinical isolates from military patients and found that it was lytic against 30/36 (83%) of strains. Human monocyte-derived dendritic cells were used to test for an in vitro phage-specific inflammatory response. Repeated experiments demonstrated that phage K had little impact on the expression of pro- and anti-inflammatory cytokines, or on MHC-I/II and CD80/CD86 protein expression. Given that dendritic cells are potent antigen-presenting cells and messengers between the innate and the adaptive immune systems, our results suggest that phage K does not independently affect cellular immunity or has a very limited impact on it.

scholarly journals Stimulation of Innate and Adaptive Immunity by Using Filamentous Bacteriophage fd Targeted to DEC-205

2015 ◽  
Vol 2015 ◽  
pp. 1-11 ◽  
Author(s):  
Luciana D’Apice ◽  
Valerio Costa ◽  
Rossella Sartorius ◽  
Maria Trovato ◽  
Marianna Aprile ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Adaptive Immune Response ◽  
Antibody Fragment ◽  
Antigenic Determinants ◽  
Rna Seq ◽  
Single Chain ◽  
Single Chain Antibody ◽  
Filamentous Bacteriophage ◽  
Adaptive Immune

The filamentous bacteriophage fd, codisplaying antigenic determinants and a single chain antibody fragment directed against the dendritic cell receptor DEC-205, is a promising vaccine candidate for its safety and its ability to elicit innate and adaptive immune response in absence of adjuvants. By using a system vaccinology approach based on RNA-Sequencing (RNA-Seq) analysis, we describe a relevant gene modulation in dendritic cells pulsed with anti-DEC-205 bacteriophages fd. RNA-Seq data analysis indicates that the bacteriophage fd virions are sensed as a pathogen by dendritic cells; they activate the danger receptors that trigger an innate immune response and thus confer a strong adjuvanticity that is needed to obtain a long-lasting adaptive immune response.

scholarly journals Salmonella escapes adaptive immune response via SIRT2 mediated modulation of innate immune response in dendritic cells

2018 ◽  
Vol 14 (11) ◽  
pp. e1007437 ◽  
Author(s):  
Mayuri Gogoi ◽  
Kasturi Chandra ◽  
Mohsen Sarikhani ◽  
Ramya Ramani ◽  
Nagalingam Ravi Sundaresan ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Innate Immune Response ◽  
Adaptive Immune Response ◽  
Innate Immune ◽  
Adaptive Immune

scholarly journals HIV-1 Tat Addresses Dendritic Cells to Induce a Predominant Th1-Type Adaptive Immune Response That Appears Prevalent in the Asymptomatic Stage of Infection

2009 ◽  
Vol 182 (5) ◽  
pp. 2888-2897 ◽  
Author(s):  
Emanuele Fanales-Belasio ◽  
Sonia Moretti ◽  
Valeria Fiorelli ◽  
Antonella Tripiciano ◽  
Maria R. Pavone Cossut ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Adaptive Immune Response ◽  
Adaptive Immune ◽  
Asymptomatic Stage ◽  
Hiv 1

[457] HCV INFECTION OF DENDRITIC CELLS AFFECTS THEIR FUNCTION LEADING TO AN IMPAIRED ADAPTIVE IMMUNE RESPONSE

2007 ◽  
Vol 46 ◽  
pp. S174
Author(s):  
I. Pachiadakis ◽  
S. Choksi ◽  
H. Cooksley ◽  
C. Sarrazzin ◽  
S. Zeuzem ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Adaptive Immune Response ◽  
Hcv Infection ◽  
Adaptive Immune

scholarly journals Plasmodium vivax recombinant vaccine candidate AMA-1 plays an important role in adaptive immune response eliciting differentiation of dendritic cells

Vaccine ◽  
2009 ◽  
Vol 27 (41) ◽  
pp. 5581-5588 ◽  
Author(s):  
Lilian Lacerda Bueno ◽  
Cristiane Guimarães Morais ◽  
Irene da Silva Soares ◽  
Leoneide Erica Maduro Bouillet ◽  
Oscar Bruna-Romero ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Plasmodium Vivax ◽  
Vaccine Candidate ◽  
Adaptive Immune Response ◽  
Recombinant Vaccine ◽  
Adaptive Immune

scholarly journals Correction: Salmonella escapes adaptive immune response via SIRT2 mediated modulation of innate immune response in dendritic cells

2020 ◽  
Vol 16 (2) ◽  
pp. e1008345
Author(s):  
Mayuri Gogoi ◽  
Kasturi Chandra ◽  
Mohsen Sarikhani ◽  
Ramya Ramani ◽  
Nagalingam Ravi Sundaresan ◽  
...  
Keyword(s):  
Immune Response ◽  
Dendritic Cells ◽  
Innate Immune Response ◽  
Adaptive Immune Response ◽  
Innate Immune ◽  
Adaptive Immune
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