scholarly journals Ligation of Notch Receptors in Human Conventional and Plasmacytoid Dendritic Cells Differentially Regulates Cytokine and Chemokine Secretion and Modulates Th Cell Polarization

2011 ◽  
Vol 186 (12) ◽  
pp. 7006-7015 ◽  
Author(s):  
Begoña Pérez-Cabezas ◽  
Mar Naranjo-Gómez ◽  
Patricia Bastos-Amador ◽  
Gerard Requena-Fernández ◽  
Ricardo Pujol-Borrell ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Cell Polarization ◽  
Notch Receptors ◽  
Th Cell

scholarly journals Essential functions of Runx/Cbfβ in gut conventional dendritic cells for priming Rorγt+ T cells

2019 ◽  
Vol 3 (1) ◽  
pp. e201900441 ◽  
Author(s):  
Mari Tenno ◽  
Alicia Yoke Wei Wong ◽  
Mika Ikegaya ◽  
Eiji Miyauchi ◽  
Wooseok Seo ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Immune Responses ◽  
Cell Polarization ◽  
Th Cells ◽  
Th Cell ◽  
Intrinsic Mechanism ◽  
Specific Effector ◽  
Acquired Immune Responses ◽  
Type 3

Acquired immune responses are initiated by activation of CD4+ helper T (Th) cells via recognition of antigens presented by conventional dendritic cells (cDCs). DCs instruct Th-cell polarization program into specific effector Th subset, which will dictate the type of immune responses. Hence, it is important to unravel how differentiation and/or activation of DC are linked with Th-cell–intrinsic mechanism that directs differentiation toward a specific effector Th subset. Here, we show that loss of Runx/Cbfβ transcription factors complexes during DC development leads to loss of CD103+CD11b+ cDC2s and alters characteristics of CD103−CD11b+ cDCs in the intestine, which was accompanied with impaired differentiation of Rorγt+ Th17 cells and type 3 Rorγt+ regulatory T cells. We also show that a Runx-binding enhancer in the Rorc gene is essential for T cells to integrate cDC-derived signals to induce Rorγt expression. These findings reveal that Runx/Cbfβ complexes play crucial and complementary roles in cDCs and Th cells to shape converging type 3 immune responses.

scholarly journals Antigen Targeting to Plasmacytoid Dendritic Cells via Siglec-H Inhibits Th Cell-Dependent Autoimmunity

2011 ◽  
Vol 187 (12) ◽  
pp. 6346-6356 ◽  
Author(s):  
Jakob Loschko ◽  
Sylvia Heink ◽  
Daniela Hackl ◽  
Diana Dudziak ◽  
Wolfgang Reindl ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Th Cell

scholarly journals Plasmacytoid Dendritic Cells Facilitate Th Cell Cytokine Responses throughout Schistosoma mansoni Infection

2021 ◽  
Vol 5 (8) ◽  
pp. 721-732
Author(s):  
Lauren M. Webb ◽  
Alexander T. Phythian-Adams ◽  
Alice H. Costain ◽  
Sheila L. Brown ◽  
Rachel J. Lundie ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Schistosoma Mansoni ◽  
Plasmacytoid Dendritic Cells ◽  
Cytokine Responses ◽  
Th Cell

Bet v 1 and its homologous food allergen Api g 1 stimulate dendritic cells from birch pollen-allergic individuals to induce different Th-cell polarization

Allergy ◽  
2010 ◽  
Vol 65 (11) ◽  
pp. 1388-1396 ◽  
Author(s):  
U. Smole ◽  
S. Wagner ◽  
N. Balazs ◽  
C. Radauer ◽  
M. Bublin ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Food Allergen ◽  
Birch Pollen ◽  
Cell Polarization ◽  
Bet V 1 ◽  
Th Cell

scholarly journals Plasmacytoid Dendritic Cells Regulate Th Cell Responses through OX40 Ligand and Type I IFNs

2004 ◽  
Vol 172 (7) ◽  
pp. 4253-4259 ◽  
Author(s):  
Tomoki Ito ◽  
Ryuichi Amakawa ◽  
Muneo Inaba ◽  
Toshiyuki Hori ◽  
Maiko Ota ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Plasmacytoid Dendritic Cells ◽  
Type I ◽  
Cell Responses ◽  
Type I Ifns ◽  
Th Cell ◽  
Ox40 Ligand
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