scholarly journals Cutting Edge: Ku70 Is a Novel Cytosolic DNA Sensor That Induces Type III Rather Than Type I IFN

2011 ◽  
Vol 186 (8) ◽  
pp. 4541-4545 ◽  
Author(s):  
Xing Zhang ◽  
Terrence W. Brann ◽  
Ming Zhou ◽  
Jun Yang ◽  
Raphael M. Oguariri ◽  
...  
Keyword(s):  
Cutting Edge ◽  
Type I ◽  
Dna Sensor ◽  
Type I Ifn ◽  
Type Iii

SS4-4 Ku70 is a novel cytosolic DNA sensor and induces type-III IFN rather than Type-I IFN

Cytokine ◽  
2010 ◽  
Vol 52 (1-2) ◽  
pp. 42-43
Author(s):  
Xing Zhang ◽  
Terrence W. Brann ◽  
Kristy B. Lidie ◽  
Ming Zhou ◽  
Raphael M. Oguariri ◽  
...  
Keyword(s):  
Type I ◽  
Dna Sensor ◽  
Type I Ifn ◽  
Type Iii ◽  
Type Iii Ifn

scholarly journals Cutting Edge: Critical Role of IκB Kinase α in TLR7/9-Induced Type I IFN Production by Conventional Dendritic Cells

2010 ◽  
Vol 184 (7) ◽  
pp. 3341-3345 ◽  
Author(s):  
Katsuaki Hoshino ◽  
Izumi Sasaki ◽  
Takahiro Sugiyama ◽  
Takahiro Yano ◽  
Chihiro Yamazaki ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Critical Role ◽  
Cutting Edge ◽  
Type I ◽  
Type I Ifn ◽  
Iκb Kinase

scholarly journals Cutting Edge: Activation of STING in T Cells Induces Type I IFN Responses and Cell Death

2017 ◽  
Vol 199 (2) ◽  
pp. 397-402 ◽  
Author(s):  
Bridget Larkin ◽  
Vladimir Ilyukha ◽  
Maxim Sorokin ◽  
Anton Buzdin ◽  
Edouard Vannier ◽  
...  
Keyword(s):  
T Cells ◽  
Cell Death ◽  
Cutting Edge ◽  
Type I ◽  
Type I Ifn

scholarly journals Cutting Edge: Fetal/Placental Type I IFN Can Affect Maternal Survival and Fetal Viral Load during Viral Infection

2017 ◽  
Vol 198 (8) ◽  
pp. 3029-3032 ◽  
Author(s):  
Karen Racicot ◽  
Paulomi Aldo ◽  
Ayman El-Guindy ◽  
Ja-Young Kwon ◽  
Roberto Romero ◽  
...  
Keyword(s):  
Viral Load ◽  
Viral Infection ◽  
Cutting Edge ◽  
Type I ◽  
Type I Ifn ◽  
Maternal Survival

scholarly journals Cutting Edge: Oral Type I IFN-τ Promotes a Th2 Bias and Enhances Suppression of Autoimmune Encephalomyelitis by Oral Glatiramer Acetate

2002 ◽  
Vol 169 (5) ◽  
pp. 2231-2235 ◽  
Author(s):  
Jeanne M. Soos ◽  
Olaf Stüve ◽  
Sawsan Youssef ◽  
Manuel Bravo ◽  
Howard M. Johnson ◽  
...  
Keyword(s):  
Glatiramer Acetate ◽  
Cutting Edge ◽  
Type I ◽  
Type I Ifn ◽  
Autoimmune Encephalomyelitis

scholarly journals 975. Roles of Type I and III Interferon in Severe Pathogenesis of Human Metapneumovirus

2019 ◽  
Vol 6 (Supplement_2) ◽  
pp. S34-S35
Author(s):  
John V Williams ◽  
Yu Zhang ◽  
Jiuyang Xu ◽  
Margot Miranda-Katz ◽  
Helen Rich ◽  
...  
Keyword(s):  
Weight Loss ◽  
Disease Severity ◽  
Severe Disease ◽  
Human Metapneumovirus ◽  
Mouse Strains ◽  
Type I ◽  
Viral Titer ◽  
Type I Ifn ◽  
Type Iii ◽  
Type Iii Ifn

Abstract Background Human metapneumovirus (HMPV) is a leading cause of respiratory tract infection in children and adults. However, mechanisms of pathogenesis are not fully understood. Methods We tested HMPV clinical and laboratory isolates in an established C57BL/6 mouse model and measured weight loss, airway function, and viral titers. Immune responses were determined using cytokine quantitation and flow cytometry. Results HMPV clinical isolates induced variable disease severity ranging from mild to fatal disease. Laboratory strain TN/94-49 did not cause weight loss, but mice infected with clinical isolate C2-202 showed dramatic weight loss and 40% mortality within 5 days post-infection (Figure 1). These findings were confirmed in other inbred mouse strains. C2-202-infected mice also suffered from impaired pulmonary function post-recovery. Lung viral titer did not correlate with disease severity, suggesting immune-mediated pathogenesis. C2-202-infected mice exhibited increased production of type I and III interferons (IFN) and pro-inflammatory cytokines, and lung neutrophil infiltration. However, neutrophil depletion or inflammasome inactivation did not reduce disease. Stat1/Stat2 double knockout (KO) mice lacking type I and III IFN signaling exhibited reduced weight loss but increased lung viral titer after C2-202 infection (Figure 2). Type I IFN receptor (IFNAR) KO mice infected with C2-202 had reduced weight loss but unchanged lung viral titer (Figure 3), while the addition of type III IFN blockade to C2-202-infected IFNAR mice had no effect on disease but increased lung viral titer (Figure 4). Conclusion These results suggest that severe disease caused by virulent HMPV was due to exuberant IFN response. Moreover, type I IFN was primarily associated with disease, while type III IFN was associated with viral clearance. These data suggest that IFN signaling plays an important role in HMPV pathogenesis, and thus serves as a potential therapeutic target. Disclosures All Authors: No reported Disclosures.

scholarly journals Cutting Edge: Enhancement of Antibody Responses Through Direct Stimulation of B and T Cells by Type I IFN

2006 ◽  
Vol 176 (4) ◽  
pp. 2074-2078 ◽  
Author(s):  
Agnes Le Bon ◽  
Clare Thompson ◽  
Elisabeth Kamphuis ◽  
Vanessa Durand ◽  
Cornelia Rossmann ◽  
...  
Keyword(s):  
T Cells ◽  
Cutting Edge ◽  
Antibody Responses ◽  
Type I ◽  
Type I Ifn ◽  
Edge Enhancement ◽  
Direct Stimulation ◽  
Stimulation Of

scholarly journals Cutting Edge: Type I IFN Drives Emergency Myelopoiesis and Peripheral Myeloid Expansion during Chronic TLR7 Signaling

2013 ◽  
Vol 190 (3) ◽  
pp. 886-891 ◽  
Author(s):  
Matthew B. Buechler ◽  
Thomas H. Teal ◽  
Keith B. Elkon ◽  
Jessica A. Hamerman
Keyword(s):  
Cutting Edge ◽  
Type I ◽  
Type I Ifn ◽  
Edge Type ◽  
Emergency Myelopoiesis
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