scholarly journals Intrinsic IL-21 Signaling Is Critical for CD8 T Cell Survival and Memory Formation in Response to Vaccinia Viral Infection

2011 ◽  
Vol 186 (5) ◽  
pp. 2729-2738 ◽  
Author(s):  
Patricia Novy ◽  
Xiaopei Huang ◽  
Warren J. Leonard ◽  
Yiping Yang
Keyword(s):  
T Cell ◽  
Viral Infection ◽  
Cell Survival ◽  
Cd8 T Cell ◽  
Memory Formation ◽  
T Cell Survival

scholarly journals Autophagy is essential for effector CD8+ T cell survival and memory formation

2014 ◽  
Vol 15 (12) ◽  
pp. 1152-1161 ◽  
Author(s):  
Xiaojin Xu ◽  
Koichi Araki ◽  
Shuzhao Li ◽  
Jin-Hwan Han ◽  
Lilin Ye ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Cd8 T Cell ◽  
Memory Formation ◽  
T Cell Survival

scholarly journals IL-15 signaling promotes adoptive effector T-cell survival and memory formation in irradiation-induced lymphopenia

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Aizhang Xu ◽  
Kalpana Kalyanasundaram Bhanumathy ◽  
Jie Wu ◽  
Zhenmin Ye ◽  
Andrew Freywald ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Memory Formation ◽  
Effector T Cell ◽  
T Cell Survival

scholarly journals Self–class I MHC molecules support survival of naive CD8 T cells, but depress their functional sensitivity through regulation of CD8 expression levels

2009 ◽  
Vol 206 (10) ◽  
pp. 2253-2269 ◽  
Author(s):  
Kensuke Takada ◽  
Stephen C. Jameson
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Survival ◽  
Cd8 T Cells ◽  
Cd8 T Cell ◽  
Class I ◽  
Class I Mhc ◽  
Mhc Molecules ◽  
T Cell Survival ◽  
And Function

Previous studies have suggested that naive CD8 T cells require self-peptide–major histocompatability complex (MHC) complexes for maintenance. However, interpretation of such studies is complicated because of the involvement of lymphopenic animals, as lymphopenia drastically alters naive T cell homeostasis and function. In this study, we explored naive CD8 T cell survival and function in nonlymphopenic conditions by using bone marrow chimeric donors and hosts in which class I MHC expression is absent or limited to radiosensitive versus radioresistant cells. We found that long-term survival of naive CD8 T cells (but not CD4 T cells) was impaired in the absence of class I MHC. However, distinct from this effect, class I MHC deprivation also enhanced naive CD8 T cell responsiveness to low-affinity (but not high-affinity) peptide–MHC ligands. We found that this improved sensitivity was a consequence of up-regulated CD8 levels, which was mediated through a transcriptional mechanism. Hence, our data suggest that, in a nonlymphopenic setting, self-class I MHC molecules support CD8 T cell survival, but that these interactions also attenuate naive T cell sensitivity by dynamic tuning of CD8 levels.

scholarly journals TSC1/2 Signaling Complex Is Essential for Peripheral Naïve CD8+ T Cell Survival and Homeostasis in Mice

PLoS ONE ◽  
2012 ◽  
Vol 7 (2) ◽  
pp. e30592 ◽  
Author(s):  
Lianjun Zhang ◽  
Hongbing Zhang ◽  
Lanlan Li ◽  
Yi Xiao ◽  
Enyu Rao ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Cd8 T Cell ◽  
Signaling Complex ◽  
T Cell Survival

scholarly journals CD4 T Cells Are Required for CD8 T Cell Survival during Both Primary and Memory Recall Responses

2007 ◽  
Vol 179 (12) ◽  
pp. 8243-8251 ◽  
Author(s):  
Patricia Novy ◽  
Michael Quigley ◽  
Xiaopei Huang ◽  
Yiping Yang
Keyword(s):  
T Cells ◽  
T Cell ◽  
Cell Survival ◽  
Cd4 T Cells ◽  
Cd8 T Cell ◽  
Memory Recall ◽  
T Cell Survival

scholarly journals Regulation of A1 by OX40 Contributes to CD8+ T Cell Survival and Anti-Tumor Activity

PLoS ONE ◽  
2013 ◽  
Vol 8 (8) ◽  
pp. e70635 ◽  
Author(s):  
Fengyang Lei ◽  
Jianyong Song ◽  
Rizwanul Haque ◽  
Mohammad Haque ◽  
Xiaofang Xiong ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Cd8 T Cell ◽  
T Cell Survival ◽  
Anti Tumor Activity

scholarly journals CD8+ T cell survival in lethal fungal sepsis was ameliorated by T-cell-specific mTOR deletion

2021 ◽  
Vol 18 (13) ◽  
pp. 3004-3013
Author(s):  
Hao Wang ◽  
Wen Han ◽  
Ran Guo ◽  
Guangxu Bai ◽  
Jianwei Chen ◽  
...  
Keyword(s):  
T Cell ◽  
Cell Survival ◽  
Cd8 T Cell ◽  
Fungal Sepsis ◽  
T Cell Survival
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