scholarly journals Pulmonary Surfactant Protein A Enhances Endolysosomal Trafficking in Alveolar Macrophages through Regulation of Rab7

2011 ◽  
Vol 186 (4) ◽  
pp. 2397-2411 ◽  
Author(s):  
Vicky Sender ◽  
Christina Moulakakis ◽  
Cordula Stamme
Keyword(s):  
Alveolar Macrophages ◽  
Pulmonary Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Pulmonary Surfactant Protein

Pulmonary Surfactant Protein A-Mediated Enrichment of Surface-Decorated Polymeric Nanoparticles in Alveolar Macrophages

2016 ◽  
Vol 13 (12) ◽  
pp. 4168-4178 ◽  
Author(s):  
Christian A. Ruge ◽  
Hervé Hillaireau ◽  
Nadège Grabowski ◽  
Mortiz Beck-Broichsitter ◽  
Olga Cañadas ◽  
...  
Keyword(s):  
Alveolar Macrophages ◽  
Pulmonary Surfactant ◽  
Polymeric Nanoparticles ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Pulmonary Surfactant Protein

Screening and Identification of Aptamers Against Pulmonary Surfactant Protein A

2013 ◽  
Vol 41 (11) ◽  
pp. 1659-1663 ◽  
Author(s):  
Li-Juan LIU ◽  
Yi CHEN ◽  
Wei WANG ◽  
Chao CHEN ◽  
Ming-Hao GAO ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Screening And Identification ◽  
Pulmonary Surfactant Protein

Introduction of Mannose Binding Protein-Type Phosphatidylinositol Recognition into Pulmonary Surfactant Protein A†

Biochemistry ◽  
1999 ◽  
Vol 38 (22) ◽  
pp. 7321-7331 ◽  
Author(s):  
Hirofumi Chiba ◽  
Hitomi Sano ◽  
Masaki Saitoh ◽  
Hitoshi Sohma ◽  
Dennis R. Voelker ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Binding Protein ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Mannose Binding Protein ◽  
Mannose Binding ◽  
Pulmonary Surfactant Protein

Pulmonary surfactant protein A-mediated uptake of phosphatidylcholine by alveolar type II cells

1993 ◽  
Vol 265 (2) ◽  
pp. L193-L199 ◽  
Author(s):  
A. Tsuzuki ◽  
Y. Kuroki ◽  
T. Akino
Keyword(s):  
Pulmonary Surfactant ◽  
Protein A ◽  
Lamellar Body ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Alveolar Type ◽  
Type Ii Cells ◽  
Type Ii ◽  
Lamellar Bodies ◽  
Pulmonary Surfactant Protein

Pulmonary surfactant protein A (SP-A)-mediated uptake of phosphatidylcholine (PC) by alveolar type II cells was investigated. SP-A enhanced the uptake of liposomes containing dipalmitoylphosphatidylcholine (DPPC), 1-palmitoyl-2-linoleoyl phosphatidylcholine (PLPC), or 1,2-dihexadecyl-sn-glycero-3-phosphocholine (DPPC-ether), a diether analogue of DPPC, but about twice as much DPPC was taken up by type II cells as PLPC or DPPC-ether. When subcellular distribution was analyzed, 51.3 +/- 2.9% (mean +/- SD, n = 3) of cell-associated radiolabeled DPPC was recovered in the lamellar body-rich fraction in the presence of SP-A, whereas only 19.3 +/- 1.9% (mean +/- SD, n = 3) was found to this fraction in the absence of SP-A. When type II cells were incubated either with DPPC at 0 degree C or with DPPC-ether at 37 degrees C, or no cells were included, low proportions of the cell-associated lipids were present in the fractions corresponding to lamellar bodies even in the presence of SP-A. Anti-SP-A antibody significantly reduced the radioactivity incorporated into the lamellar body fraction. Phosphatidylcholine that had been incorporated into lamellar bodies remained largely intact when SP-A was present. Subcellular fractionations of type II cells with radiolabeled SP-A and DPPC revealed that the sedimentation characteristics of cell-associated SP-A are different from those of DPPC, although a small broad peak of radiolabeled SP-A was found in the lamellar body fraction.(ABSTRACT TRUNCATED AT 250 WORDS)

scholarly journals Pulmonary Surfactant Protein A Protects Lung Epithelium from Cytotoxicity of Human β-Defensin 3

2012 ◽  
Vol 287 (18) ◽  
pp. 15034-15043 ◽  
Author(s):  
Atsushi Saito ◽  
Shigeru Ariki ◽  
Hitoshi Sohma ◽  
Chiaki Nishitani ◽  
Kanako Inoue ◽  
...  
Keyword(s):  
Pulmonary Surfactant ◽  
Protein A ◽  
Surfactant Protein ◽  
Surfactant Protein A ◽  
Lung Epithelium ◽  
Pulmonary Surfactant Protein
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