scholarly journals Self-Tolerance Checkpoints in CD4 T Cells Specific for a Peptide Derived from the B Cell Antigen Receptor

2011 ◽  
Vol 187 (1) ◽  
pp. 82-91 ◽  
Author(s):  
Thiago Detanico ◽  
Ryan A. Heiser ◽  
Katja Aviszus ◽  
Cristina Bonorino ◽  
Lawrence J. Wysocki
Keyword(s):  
T Cells ◽  
B Cell ◽  
Cd4 T Cells ◽  
Antigen Receptor ◽  
B Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Self Tolerance

B-cell antigen receptor activates transcription factors NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB) via a mechanism that involves diacylglycerol

2004 ◽  
Vol 32 (1) ◽  
pp. 113-115 ◽  
Author(s):  
P. Antony ◽  
J.B. Petro ◽  
G. Carlesso ◽  
N.P. Shinners ◽  
J. Lowe ◽  
...  
Keyword(s):  
T Cells ◽  
Transcription Factors ◽  
B Cell ◽  
Antigen Receptor ◽  
Nuclear Factor Κb ◽  
B Cell Antigen Receptor ◽  
Nuclear Factor ◽  
Activated T Cells ◽  
Cell Antigen Receptor ◽  
Cell Antigen

Engagement of the B-cell antigen receptor (BCR) induces the activation of various transcription factors, including NFAT (nuclear factor of activated T-cells) and NF-κB (nuclear factor κB), which participate in long-term biological responses such as proliferation, survival and differentiation of B-lymphocytes. We addressed the biochemical basis of this process using the DT40 chicken B-cell lymphoma. We discovered that Bruton's tyrosine kinase (BTK) and phospholipase C-γ2 (PLC-γ2) are required to activate NFAT and NF-κB, and to produce the lipid second messenger diacylglycerol in response to BCR cross-linking. Therefore the functional integrity of the BTK/PLC-γ2/diacylglycerol signalling axis is crucial for BCR-directed activation of both transcription factors NFAT and NF-κB.

scholarly journals B Cell Antigen Receptor Endocytosis and Antigen Presentation to T Cells Require Vav and Dynamin

2009 ◽  
Vol 284 (36) ◽  
pp. 24088-24097 ◽  
Author(s):  
Shikha Malhotra ◽  
Susan Kovats ◽  
Weiguo Zhang ◽  
K. Mark Coggeshall
Keyword(s):  
T Cells ◽  
B Cell ◽  
Antigen Presentation ◽  
Antigen Receptor ◽  
B Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen ◽  
Receptor Endocytosis

scholarly journals The B cell antigen receptor in atypical chronic lymphocytic leukemia with t(14;19)(q32;q13) demonstrates remarkable stereotypy

2010 ◽  
Vol 128 (11) ◽  
pp. 2759-2764 ◽  
Author(s):  
Carmen D. Schweighofer ◽  
Yang O. Huh ◽  
Rajyalakshmi Luthra ◽  
Rachel L. Sargent ◽  
Rhett P. Ketterling ◽  
...  
Keyword(s):  
Chronic Lymphocytic Leukemia ◽  
B Cell ◽  
Antigen Receptor ◽  
Lymphocytic Leukemia ◽  
B Cell Antigen Receptor ◽  
Cell Antigen Receptor ◽  
Cell Antigen
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