scholarly journals TLR5 as an Anti-Inflammatory Target and Modifier Gene in Cystic Fibrosis

2010 ◽  
Vol 185 (12) ◽  
pp. 7731-7738 ◽  
Author(s):  
Christoph J. Blohmke ◽  
Julie Park ◽  
Aaron F. Hirschfeld ◽  
Rachel E. Victor ◽  
Julia Schneiderman ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Modifier Gene ◽  
Anti Inflammatory

scholarly journals Targeted Drug Delivery Technologies Potentiate the Overall Therapeutic Efficacy of an Indole Derivative in a Mouse Cystic Fibrosis Setting

Cells ◽  
2021 ◽  
Vol 10 (7) ◽  
pp. 1601
Author(s):  
Matteo Puccetti ◽  
Marilena Pariano ◽  
Giorgia Renga ◽  
Ilaria Santarelli ◽  
Fiorella D’Onofrio ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Targeted Drug Delivery ◽  
Fungal Infections ◽  
Murine Models ◽  
Multisystem Disease ◽  
Aryl Hydrocarbon ◽  
Target Organs ◽  
Infection And Inflammation ◽  
Anti Inflammatory ◽  
Inflammatory Toxicity

Inflammation plays a major role in the pathophysiology of cystic fibrosis (CF), a multisystem disease. Anti-inflammatory therapies are, therefore, of interest in CF, provided that the inhibition of inflammation does not compromise the ability to fight pathogens. Here, we assess whether indole-3-aldehyde (3-IAld), a ligand of the aryl hydrocarbon receptor (AhR), may encompass such an activity. We resorted to biopharmaceutical technologies in order to deliver 3-IAld directly into the lung, via dry powder inhalation, or into the gut, via enteric microparticles, in murine models of CF infection and inflammation. We found the site-specific delivery of 3-IAld to be an efficient strategy to restore immune and microbial homeostasis in CF organs, and mitigate lung and gut inflammatory pathology in response to fungal infections, in the relative absence of local and systemic inflammatory toxicity. Thus, enhanced delivery to target organs of AhR agonists, such as 3-IAld, may pave the way for the development of safe and effective anti-inflammatory agents in CF.

scholarly journals Identification of IFRD1 as a modifier gene for cystic fibrosis lung disease

Nature ◽  
2009 ◽  
Vol 458 (7241) ◽  
pp. 1039-1042 ◽  
Author(s):  
YuanYuan Gu ◽  
Isaac T. W. Harley ◽  
Lindsay B. Henderson ◽  
Bruce J. Aronow ◽  
Ilja Vietor ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Lung Disease ◽  
Modifier Gene ◽  
Cystic Fibrosis Lung ◽  
Cystic Fibrosis Lung Disease

Anti-inflammatory effects of montelukast in mild cystic fibrosis

2002 ◽  
Vol 89 (6) ◽  
pp. 599-605 ◽  
Author(s):  
Sabina Schmitt-Grohé ◽  
Olaf Eickmeier ◽  
Ralf Schubert ◽  
Christina Bez ◽  
Stefan Zielen
Keyword(s):  
Cystic Fibrosis ◽  
Anti Inflammatory

Levels of pro- and anti-inflammatory cytokines in cystic fibrosis patients with or without gingivitis

Cytokine ◽  
2020 ◽  
Vol 127 ◽  
pp. 154987 ◽  
Author(s):  
Onurcem Duruel ◽  
Ezel Berker ◽  
Cansu Özşin-Özler ◽  
Mina Gharibzadeh-Hızal ◽  
Öznur Gürpınar ◽  
...  
Keyword(s):  
Cystic Fibrosis ◽  
Inflammatory Cytokines ◽  
Anti Inflammatory
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