scholarly journals Targeted Complement Inhibitors Protect against Posttransplant Cardiac Ischemia and Reperfusion Injury and Reveal an Important Role for the Alternative Pathway of Complement Activation

2010 ◽  
Vol 185 (11) ◽  
pp. 7007-7013 ◽  
Author(s):  
Carl Atkinson ◽  
Songqing He ◽  
Keeley Morris ◽  
Fei Qiao ◽  
Sarah Casey ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Complement Activation ◽  
Alternative Pathway ◽  
Cardiac Ischemia ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Complement Inhibitors ◽  
Alternative Pathway Of Complement

scholarly journals Enhanced nitration of several mitochondrial proteins during cardiac ischemia and reperfusion injury

2010 ◽  
Vol 24 (S1) ◽  
Author(s):  
Meiying Yang ◽  
Amadou K.S. Camara ◽  
Ashish K. Gadicherla ◽  
Bassam Wakim ◽  
Mohammed Aldakkak ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cardiac Ischemia ◽  
Mitochondrial Proteins ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury

scholarly journals Profiling the Murine SUMO Proteome in Response to Cardiac Ischemia and Reperfusion Injury

Molecules ◽  
2020 ◽  
Vol 25 (23) ◽  
pp. 5571
Author(s):  
Paul W. Hotz ◽  
Marion Wiesnet ◽  
Georg Tascher ◽  
Thomas Braun ◽  
Stefan Müller ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Protein Quality ◽  
Cardiac Ischemia ◽  
Mouse Heart ◽  
Coronary Artery Ligation ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury ◽  
Dynamic Changes ◽  
Artery Ligation ◽  
Target Proteins

SUMOylation is a reversible posttranslational modification pathway catalyzing the conjugation of small ubiquitin-related modifier (SUMO) proteins to lysine residues of distinct target proteins. SUMOylation modifies a wide variety of cellular regulators thereby affecting a multitude of key processes in a highly dynamic manner. The SUMOylation pathway displays a hallmark in cellular stress-adaption, such as heat or redox stress. It has been proposed that enhanced cellular SUMOylation protects the brain during ischemia, however, little is known about the specific regulation of the SUMO system and the potential target proteins during cardiac ischemia and reperfusion injury (I/R). By applying left anterior descending (LAD) coronary artery ligation and reperfusion in mice, we detect dynamic changes in the overall cellular SUMOylation pattern correlating with decreased SUMO deconjugase activity during I/R injury. Further, unbiased system-wide quantitative SUMO-proteomics identified a sub-group of SUMO targets exhibiting significant alterations in response to cardiac I/R. Notably, transcription factors that control hypoxia- and angiogenesis-related gene expression programs, exhibit altered SUMOylation during ischemic stress adaptation. Moreover, several components of the ubiquitin proteasome system undergo dynamic changes in SUMO conjugation during cardiac I/R suggesting an involvement of SUMO signaling in protein quality control and proteostasis in the ischemic heart. Altogether, our study reveals regulated candidate SUMO target proteins in the mouse heart, which might be important in coping with hypoxic/proteotoxic stress during cardiac I/R injury.

scholarly journals Superoxide flashes: illuminating new insights into cardiac ischemia and reperfusion injury

2008 ◽  
Vol 4 (6) ◽  
pp. 551-554 ◽  
Author(s):  
Shey-Shing Sheu ◽  
Wang Wang ◽  
Heping Cheng ◽  
Robert T Dirksen
Keyword(s):  
Reperfusion Injury ◽  
Cardiac Ischemia ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury

scholarly journals Ranolazine Reduces Mitochondrial Tyrosine Nitration During Cardiac Ischemia and Reperfusion Injury

2010 ◽  
Vol 98 (3) ◽  
pp. 379a
Author(s):  
Meiying Yang ◽  
Ashish K. Gadicherla ◽  
David F. Stowe ◽  
Martin Bienengraeber ◽  
Bassam Wakim ◽  
...  
Keyword(s):  
Reperfusion Injury ◽  
Cardiac Ischemia ◽  
Tyrosine Nitration ◽  
Ischemia And Reperfusion ◽  
Ischemia And Reperfusion Injury
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