scholarly journals Remarkable Conservation of Distinct Nonclassical MHC Class I Lineages in Divergent Amphibian Species

2010 ◽  
Vol 186 (1) ◽  
pp. 372-381 ◽  
Author(s):  
Ana Goyos ◽  
Jessica Sowa ◽  
Yuko Ohta ◽  
Jacques Robert
Keyword(s):  
Mhc Class I ◽  
Class I ◽  
Amphibian Species ◽  
Nonclassical Mhc

II. One size fits all: nonclassical MHC molecules fulfill multiple roles in epithelial cell function

1998 ◽  
Vol 274 (2) ◽  
pp. G227-G231 ◽  
Author(s):  
Richard S. Blumberg
Keyword(s):  
Epithelial Cell ◽  
Mhc Class I ◽  
Cell Biology ◽  
Cell Function ◽  
Surface Glycoprotein ◽  
Class I ◽  
Human Major Histocompatibility Complex ◽  
Cell Surface Glycoprotein ◽  
Mhc Molecules ◽  
Nonclassical Mhc

The human major histocompatibility complex (MHC) on chromosome 6 encodes three classical class I genes: human leukocyte antigen-A (HLA-A), HLA-B, and HLA-C. These polymorphic genes encode a 43- to 45-kDa cell surface glycoprotein that, in association with the 12-kDa β2-microglobulin molecule, functions in the presentation of nine amino acid peptides to the T cell receptor of CD8-bearing T lymphocytes and killer inhibitory receptors on natural killer cells. In addition to these ubiquitously expressed polymorphic proteins, the human genome also encodes a number of nonclassical MHC class I-like, or class Ib, genes that in general encode nonpolymorphic molecules involved in a variety of specific immunologic functions. Many of these genes, including CD1, the neonatal Fc receptor for immunoglobulin G, HLA-G, the MHC class I chain-related gene A, and Hfe, are prominently displayed on epithelial cells, suggesting an important role in epithelial cell biology.

scholarly journals A nonclassical MHC class I U lineage locus in zebrafish with a null haplotypic variant

2015 ◽  
Vol 67 (9) ◽  
pp. 501-513 ◽  
Author(s):  
Hayley Dirscherl ◽  
Jeffrey A. Yoder
Keyword(s):  
Mhc Class I ◽  
Class I ◽  
Nonclassical Mhc

Specialized function of the nonclassical MHC class I molecule Hmt: A specific receptor for N-formylated peptides

1991 ◽  
Vol 10 (3-4) ◽  
pp. 365-375 ◽  
Author(s):  
Said M. Shawar ◽  
John R. Rodgers ◽  
Richard G. Cook ◽  
Robert R. Rich
Keyword(s):  
Mhc Class I ◽  
Class I ◽  
Specific Receptor ◽  
Mhc Class I Molecule ◽  
Specialized Function ◽  
Nonclassical Mhc

scholarly journals Nonclassical MHC class I-dependent invariant T cells are evolutionarily conserved and prominent from early development in amphibians

2013 ◽  
Vol 110 (35) ◽  
pp. 14342-14347 ◽  
Author(s):  
E.-S. Edholm ◽  
L.-M. Albertorio Saez ◽  
A. L. Gill ◽  
S. R. Gill ◽  
L. Grayfer ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class I ◽  
Early Development ◽  
Class I ◽  
Evolutionarily Conserved ◽  
Invariant T Cells ◽  
Nonclassical Mhc

scholarly journals Erratum: Recognition of the nonclassical MHC class I molecule H2-M3 by the receptor Ly49A regulates the licensing and activation of NK cells

2013 ◽  
Vol 14 (4) ◽  
pp. 413-413
Author(s):  
Daniel M Andrews ◽  
Lucy C Sullivan ◽  
Nikola Baschuk ◽  
Christopher J Chan ◽  
Richard Berry ◽  
...  
Keyword(s):  
Nk Cells ◽  
Mhc Class I ◽  
Class I ◽  
Mhc Class I Molecule ◽  
Nonclassical Mhc

scholarly journals The Nonclassical MHC Class I Molecule Qa-1 Forms Unstable Peptide Complexes

2004 ◽  
Vol 172 (3) ◽  
pp. 1661-1669 ◽  
Author(s):  
Taku Kambayashi ◽  
Jennifer R. Kraft-Leavy ◽  
Joseph G. Dauner ◽  
Barbara A. Sullivan ◽  
Oskar Laur ◽  
...  
Keyword(s):  
Mhc Class I ◽  
Class I ◽  
Mhc Class I Molecule ◽  
Peptide Complexes ◽  
Nonclassical Mhc

scholarly journals Qa-2–Dependent Selection of Cd8α/α T Cell Receptor α/β+ Cells in Murine Intestinal Intraepithelial Lymphocytes

2000 ◽  
Vol 192 (10) ◽  
pp. 1521-1528 ◽  
Author(s):  
Gobardhan Das ◽  
Dina S. Gould ◽  
Mathew M. Augustine ◽  
Gladis Fragoso ◽  
Edda Scitto ◽  
...  
Keyword(s):  
T Cells ◽  
Mhc Class I ◽  
Antigen Processing ◽  
Intraepithelial Lymphocytes ◽  
Class I ◽  
Β Cells ◽  
Double Knockout ◽  
Intestinal Intraepithelial Lymphocytes ◽  
Mhc Class I Molecule ◽  
Nonclassical Mhc

Murine intestinal intraepithelial lymphocytes (iIELs) are made up of a heterogeneous mix of T cells with unique phenotypes. Whereas CD8+ T cells in peripheral lymphoid organs use CD8α/β and are selected on MHC class Ia molecules, a majority of iIELs use CD8α/α. Here, we report that the presence of CD8α/α TCR-α/β cells in iIELs is independent of classical MHC class I molecules Kb and Db, as illustrated by their presence in Kb/Db double-knockout mice and in mice lacking a nonclassical MHC class I molecule, CD1d. Most strikingly, their presence is decreased by ∼70% in mice lacking transporter associated with antigen processing (TAP). The TAP-dependent nonclassical MHC class I molecule Qa-2 is strongly implicated in the presence of these cells, as inferred from the low numbers of CD8α/α TCR-α/β T cells in mice deficient in Qa-2 genes. Second, a Qa-2–transgenic mouse made in a Qa-2− strain showed an increase in the numbers of CD8α/α cells among its iIELs. Thus, the presence of CD8α/α TCR-α/β cells in iIELs is mainly dependent on the nonclassical MHC class I molecule Qa-2.

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