scholarly journals Docosahexaenoic Acid-Enriched Fish Oil Attenuates Kidney Disease and Prolongs Median and Maximal Life Span of Autoimmune Lupus-Prone Mice

2010 ◽  
Vol 184 (9) ◽  
pp. 5280-5286 ◽  
Author(s):  
Ganesh V. Halade ◽  
Md Mizanur Rahman ◽  
Arunabh Bhattacharya ◽  
Jeffrey L. Barnes ◽  
Bysani Chandrasekar ◽  
...  
Keyword(s):  
Kidney Disease ◽  
Docosahexaenoic Acid ◽  
Fish Oil ◽  
Life Span ◽  
Maximal Life Span

scholarly journals Docosahexaenoic acid‐enriched fish oil attenuates kidney disease and prolongs median and maximal life span of autoimmune lupus ‐prone mice

2007 ◽  
Vol 21 (5) ◽  
Author(s):  
Gabriel Fernandes ◽  
Md Mizanur Rahman ◽  
Bhattacharya Arunabh ◽  
Bysani Chandrasekar
Keyword(s):  
Kidney Disease ◽  
Docosahexaenoic Acid ◽  
Fish Oil ◽  
Life Span ◽  
Maximal Life Span

Saccharomyces cerevisiae SSD1-VConfers Longevity by a Sir2p-Independent Mechanism

Genetics ◽  
2004 ◽  
Vol 166 (4) ◽  
pp. 1661-1672 ◽  
Author(s):  
Matt Kaeberlein ◽  
Alex A Andalis ◽  
Gregory B Liszt ◽  
Gerald R Fink ◽  
Leonard Guarente
Keyword(s):  
Saccharomyces Cerevisiae ◽  
Life Span ◽  
Cell Cycle Progression ◽  
Polymorphic Locus ◽  
Cell Integrity ◽  
Cycle Progression ◽  
Cellular Processes ◽  
Maximal Life Span ◽  
Independent Mechanism ◽  
Yeast Aging

AbstractThe SSD1 gene of Saccharomyces cerevisiae is a polymorphic locus that affects diverse cellular processes including cell integrity, cell cycle progression, and growth at high temperature. We show here that the SSD1-V allele is necessary for cells to achieve extremely long life span. Furthermore, addition of SSD1-V to cells can increase longevity independently of SIR2, although SIR2 is necessary for SSD1-V cells to attain maximal life span. Past studies of yeast aging have been performed in short-lived ssd1-d strain backgrounds. We propose that SSD1-V defines a previously undescribed pathway affecting cellular longevity and suggest that future studies on longevity-promoting genes should be carried out in long-lived SSD1-V strains.

Effects of fish oil containing eicosapentaenoic acid and docosahexaenoic acid on dystrophic mdx mice

2013 ◽  
Vol 32 (4) ◽  
pp. 636-642 ◽  
Author(s):  
Adriana Fogagnolo Mauricio ◽  
Elaine Minatel ◽  
Humberto Santo Neto ◽  
Maria Julia Marques
Keyword(s):  
Docosahexaenoic Acid ◽  
Eicosapentaenoic Acid ◽  
Fish Oil ◽  
Mdx Mice

Longer Life Spans and Delayed Maturation in Wild-Derived Mice

2002 ◽  
Vol 227 (7) ◽  
pp. 500-508 ◽  
Author(s):  
Richard A. Miller ◽  
James M. Harper ◽  
Robert C. Dysko ◽  
Stephen J. Durkee ◽  
Steven N. Austad
Keyword(s):  
Life Span ◽  
Glycosylated Hemoglobin ◽  
Large Body ◽  
Aging Research ◽  
Maximal Life Span ◽  
Common Stocks ◽  
Physiology And Biochemistry ◽  
The Common ◽  
Delayed Maturation ◽  
Laboratory Breeding

Nearly all the experimental mice used in aging research are derived from lineages that have been selected for many generations for adaptation to laboratory breeding conditions and are subsequently inbred. To see if inbreeding and laboratory adaptation might have altered the frequencies of genes that influence life span, we have developed three lines of mice (Idaho [Id], Pohnpel [Po], and Majuro [Ma]) from wild-trapped progenitors, and have compared them with a genetically heterogeneous mouse stock (DC) representative of the laboratoryadapted gene pool. Mean life span of the Id stock exceeded that of the DC stock by 24% (P < 0.00002), and maximal life span, estimated as mean longevity of the longest-lived 10% of the mice, was also increased by 16% (P < 0.003). Mice of the Ma stock also had a significantly longer maximal longevity than DC mice (9%, P = 0.04). The longest-lived Id mouse died at the age of 1450 days, which appears to exceed the previous longevity record for fully fed, non-mutant mice. The life table of the Po mice resembled that of the DC controls. Ma and Id mice differ from DC mice in several respects: both are shorter and lighter, and females of both stocks, particularly Id, are much slower to reach sexual maturity. As young adults, Id mice have lower levels of insulin-like growth factor 1 (IGF-I), leptin, and glycosylated hemoglobin compared with DC controls, implicating several biochemical pathways as potential longevity mediators. The results support the idea that inadvertent selection for rapid maturation and large body size during the adaptation of the common stocks of laboratory mice may have forced the loss of natural alleles that retard the aging process. Genes present in the Id and Ma stocks may be valuable tools for the analysis of the physiology and biochemistry of aging in mice.

scholarly journals STUDY ON THE THERMAL STABILITY OF EPA AND DHA IN MUJAHIR (Oreochromis mossambicus) FISH OIL

2010 ◽  
Vol 5 (2) ◽  
pp. 152-155 ◽  
Author(s):  
Ngatidjo Hadipranoto
Keyword(s):  
Gas Chromatography ◽  
Fatty Acid ◽  
Docosahexaenoic Acid ◽  
Eicosapentaenoic Acid ◽  
Fish Oil ◽  
Oreochromis Mossambicus ◽  
Heating Process ◽  
Fresh Water Fish ◽  
Epa And Dha ◽  
Indirect Heating

EPA (Eicosapentaenoic acid) and DHA (Docosahexaenoic acid) content in common fresh water fish : mujahir (Oreochromis mossambicus) after indirect heating were analysed. The aims of this study were to determine the effect of indirect heating process and α-tocopherol additions on both fatty acid stability.Lipids content in the mujahir fillets were extracted by Folch method using chloroform-metanol (2:1) mixture. Fatty acids in fish oil were converted to fatty acid methyl esters and then injected into gas chromatography to determine the EPA and DHA concentration. Operating condition of gas chromatography were programmed as follows: injection port temperature at 270 oC, detector at 280 oC, initial column temperature at 200 oC, and the final at 280 oC, the carrier gas was helium with flow rate of 10 ml per minute and temperature of column was increased gradually at 10 oC per minute. The effect of α-tocopherol addition on the stability of EPA and DHA was studied by adding α-tocopherol at 50 to 200 mg per kilogram sample before indirect heating process was carried out.The analysis of mujahir fish oil showed that the content of EPA and DHA in 100 grams fresh sample was 105 and 406,5 mg respectivelly. Indirect heating caused the EPA and DHA content decreased significantly. The addition of α-tocopherol results in a positive corelation between α-tocopherol concentration added and the decrease of EPA and DHA content during the heating process.   Keywords: fatty acid, eicosapentaenoic acid, docosahexaenoic acid

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