scholarly journals Signaling through the A2B Adenosine Receptor Dampens Endotoxin-Induced Acute Lung Injury

2010 ◽  
Vol 184 (9) ◽  
pp. 5271-5279 ◽  
Author(s):  
Ulrich Schingnitz ◽  
Katherine Hartmann ◽  
Christopher F. MacManus ◽  
Tobias Eckle ◽  
Stephanie Zug ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Adenosine Receptor ◽  
A2b Adenosine Receptor

Simvastatin attenuates acute lung injury by activation of A2B adenosine receptor

2021 ◽  
pp. 115460
Author(s):  
Hong-xia Li ◽  
Xiao-yan Liang ◽  
Jiong-he Wu ◽  
Ya-ping Yuan ◽  
Yue Gao ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Adenosine Receptor ◽  
A2b Adenosine Receptor

scholarly journals Identification of Hypoxia-Inducible Factor HIF-1A as Transcriptional Regulator of the A2B Adenosine Receptor during Acute Lung Injury

2014 ◽  
Vol 192 (3) ◽  
pp. 1249-1256 ◽  
Author(s):  
Tobias Eckle ◽  
Emily M. Kewley ◽  
Kelley S. Brodsky ◽  
Eunyoung Tak ◽  
Stephanie Bonney ◽  
...  
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Adenosine Receptor ◽  
Hypoxia Inducible Factor ◽  
Transcriptional Regulator ◽  
A2b Adenosine Receptor

scholarly journals Distinct Roles for the A2B Adenosine Receptor in Acute and Chronic Stages of Bleomycin-Induced Lung Injury

2010 ◽  
Vol 186 (2) ◽  
pp. 1097-1106 ◽  
Author(s):  
Yang Zhou ◽  
Daniel J. Schneider ◽  
Eva Morschl ◽  
Ling Song ◽  
Mesias Pedroza ◽  
...  
Keyword(s):  
Lung Injury ◽  
Adenosine Receptor ◽  
A2b Adenosine Receptor

scholarly journals Adenosine receptor A2b on hematopoietic cells mediates LPS-induced migration of PMNs into the lung interstitium

2012 ◽  
Vol 303 (5) ◽  
pp. L425-L438 ◽  
Author(s):  
Franziska M. Konrad ◽  
Esther Witte ◽  
Irene Vollmer ◽  
Stefanie Stark ◽  
Jörg Reutershan
Keyword(s):  
Acute Lung Injury ◽  
Lung Injury ◽  
Adenosine Receptor ◽  
Hematopoietic Cells ◽  
Microvascular Permeability ◽  
Critical Event ◽  
Cell Trafficking ◽  
Alveolar Space ◽  
Human Pmns

Uncontrolled transmigration of polymorphonuclear leukocytes (PMNs) into the different compartments of the lungs (intravascular, interstitial, alveolar) is a critical event in the early stage of acute lung injury and acute respiratory distress syndrome. Adenosine receptor A2b is highly expressed in the inflamed lungs and has been suggested to mediate cell trafficking. In a murine model of LPS-induced lung inflammation, we investigated the role of A2b on migration of PMNs into the different compartments of the lung. In A2b−/− mice, LPS-induced accumulation of PMNs was significantly higher in the interstitium, but not in the alveolar space. In addition, pulmonary clearance of PMNs was delayed in A2b−/− mice. Using chimeric mice, we identified A2b on hematopoietic cells as crucial for PMN migration. A2b did not affect the release of relevant chemokines into the alveolar space. LPS-induced microvascular permeability was under the control of A2b on both hematopoietic and nonhematopoietic cells. Activation of A2b on endothelial cells also reduced formation of LPS-induced stress fibers, highlighting its role for endothelial integrity. A specific A2b agonist (BAY 60–6583) was effective in decreasing PMN migration into the lung interstitium and microvascular permeability. In addition, in vitro transmigration of human PMNs through a layer of human endothelial or epithelial cells was A2b dependent. Activation of A2b on human PMNs reduced oxidative burst activity. Together, our results demonstrate anti-inflammatory effects of A2b on two major characteristics of acute lung injury, with a distinct role of hematopoietic A2b for cell trafficking and endothelial A2b for microvascular permeability.

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