scholarly journals Dendritic Cells and Stat3 Are Essential for CD137-Induced CD8 T Cell Activation-Induced Cell Death

2010 ◽  
Vol 184 (9) ◽  
pp. 4770-4778 ◽  
Author(s):  
Benyue Zhang ◽  
Yuanyuan Zhang ◽  
Liguo Niu ◽  
Anthony T. Vella ◽  
Robert S. Mittler
Keyword(s):  
Cell Death ◽  
Dendritic Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Activation Induced Cell Death

scholarly journals CD5 on dendritic cells regulates CD4+ and CD8+ T cell activation and induction of immune responses

PLoS ONE ◽  
2019 ◽  
Vol 14 (9) ◽  
pp. e0222301 ◽  
Author(s):  
Hui Li ◽  
Erica Burgueño-Bucio ◽  
Shin Xu ◽  
Shaonli Das ◽  
Roxana Olguin-Alor ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Immune Responses ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell

p38 MAPK Mediates Inhibition of Activation Induced Cell Death in T Lymphocytes Via Upregulation of Bcl-xL and FLIPshort upon Ligation of CD137/4-1BB or CD28.

Blood ◽  
2005 ◽  
Vol 106 (11) ◽  
pp. 3320-3320
Author(s):  
Christian Scholz ◽  
Lilian Stärck ◽  
Mario Lehmann ◽  
Bernd Dörken ◽  
Peter T. Daniel
Keyword(s):  
Cell Death ◽  
T Cell ◽  
Protein Kinase ◽  
T Lymphocytes ◽  
Family Member ◽  
P38 Mapk ◽  
T Cell Activation ◽  
Cell Activation ◽  
Activation Induced Cell Death ◽  
Costimulatory Signals

Abstract Costimulation is essential for the induction of proliferation in naive T cells and for the inhibition of activation induced cell death (AICD) in activated T lymphocytes. While costimulatory signals mediated through the immunglobulin family member CD28 play a prominent role during primary T cell activation, ligation of the tumor necrosis factor receptor family member CD137/4-1BB is more important during late primary and secondary T cell activation. Signals mediated through either costimulatory protein block AICD. Inhibition of AICD through ligation of CD137/4-1BB or CD28 involves upregulation of Bcl-xL and FLIPshort (Eur J Immunol 2005, 35: 1257–66). We further demonstrated that costimulatory signals mediated through CD137/4-1BB or CD28 depend on the activity of phosphatidylinositol 3-kinase and AKT/protein kinase B, two kinases that had formerly been implied in CD28-induced signaling, indicating that CD28- and CD137/4-1BB-mediated signals share downstream signaling pathways. Here, we demonstrate that p38 mitogen-activated protein kinase (MAPK) mediates CD137/4-1BB-induced as well as CD28-mediated costimulation of cell proliferation and inhibition of AICD. This coincides with upregulation of Bcl-xL and FLIPshort. Inhibition of p38 MAPK abrogates T cell receptor induced proliferation and antagonizes costimulation mediated survival. Thus, p38 MAPK, which was previously thought to be primarily involved in CD137/4-1BB-mediated signaling, is similarly important for CD28-induced costimulation and survival. This indicates that, while involving different protein families, signal transduction by CD28 and CD137/4-1BB depends on a common upstream and downstream network of survival kinases.

scholarly journals Plasmacytoid Dendritic Cells Take Up Opsonized Antigen Leading to CD4+and CD8+T Cell Activation In Vivo

2008 ◽  
Vol 181 (6) ◽  
pp. 3811-3817 ◽  
Author(s):  
Pia Björck ◽  
Andreas Beilhack ◽  
Edward I. Herman ◽  
Robert S. Negrin ◽  
Edgar G. Engleman
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Plasmacytoid Dendritic Cells

An emerging player in the adaptive immune response: microRNA-146a is a modulator of IL-2 expression and activation-induced cell death in T lymphocytes

Blood ◽  
2010 ◽  
Vol 115 (2) ◽  
pp. 265-273 ◽  
Author(s):  
Graziella Curtale ◽  
Franca Citarella ◽  
Claudia Carissimi ◽  
Marina Goldoni ◽  
Nicoletta Carucci ◽  
...  
Keyword(s):  
Immune Response ◽  
T Cells ◽  
Cell Death ◽  
T Cell ◽  
T Lymphocytes ◽  
T Cell Activation ◽  
Cell Activation ◽  
Interleukin 2 ◽  
Activation Induced Cell Death

Abstract Activation of the T cell–mediated immune response has been associated with changes in the expression of specific microRNAs (miRNAs). However, the role of miRNAs in the development of an effective immune response is just beginning to be explored. This study focuses on the functional role of miR-146a in T lymphocyte–mediated immune response and provides interesting clues on the transcriptional regulation of miR-146a during T-cell activation. We show that miR-146a is low in human naive T cells and is abundantly expressed in human memory T cells; consistently, miR-146a is induced in human primary T lymphocytes upon T-cell receptor (TCR) stimulation. Moreover, we identified NF-kB and c-ETS binding sites as required for the induction of miR-146a transcription upon TCR engagement. Our results demonstrate that several signaling pathways, other than inflammation, are influenced by miR-146a. In particular, we provide experimental evidence that miR-146a modulates activation-induced cell death (AICD), acting as an antiapoptotic factor, and that Fas-associated death domain (FADD) is a target of miR-146a. Furthermore, miR-146a enforced expression impairs both activator protein 1 (AP-1) activity and interleukin-2 (IL-2) production induced by TCR engagement, thus suggesting a role of this miRNA in the modulation of adaptive immunity.

scholarly journals Dendritic Cells Prime In Vivo Alloreactive CD4 T Lymphocytes Toward Type 2 Cytokine- and TGF-β-Producing Cells in the Absence of CD8 T Cell Activation

2000 ◽  
Vol 165 (9) ◽  
pp. 4994-5003 ◽  
Author(s):  
Gilles Foucras ◽  
Jérôme D. Coudert ◽  
Christiane Coureau ◽  
Jean-Charles Guéry
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Lymphocytes ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell

Naïve CD8 T cell activation by liver bone marrow-derived cells leads to a “neglected” IL-2low Bimhigh phenotype, poor CTL function and cell death

2012 ◽  
Vol 57 (4) ◽  
pp. 830-836 ◽  
Author(s):  
Lauren E. Holz ◽  
Volker Benseler ◽  
Michelle Vo ◽  
Claire McGuffog ◽  
Nico Van Rooijen ◽  
...  
Keyword(s):  
Bone Marrow ◽  
Cell Death ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Bone Marrow Derived Cells

scholarly journals Langerin+ Dermal Dendritic Cells Are Critical for CD8+ T Cell Activation and IgH γ-1 Class Switching in Response to Gene Gun Vaccines

2010 ◽  
Vol 186 (3) ◽  
pp. 1377-1383 ◽  
Author(s):  
Angelika Stoecklinger ◽  
Tekalign D. Eticha ◽  
Mehrnaz Mesdaghi ◽  
Adrien Kissenpfennig ◽  
Bernard Malissen ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Activation ◽  
Cell Activation ◽  
Cd8 T Cell ◽  
Gene Gun ◽  
Class Switching

scholarly journals Correction: The Adaptor Protein Bam32 in Human Dendritic Cells Participates in the Regulation of MHC Class I-Induced CD8+ T Cell Activation

2011 ◽  
Vol 187 (12) ◽  
pp. 6584-6584
Author(s):  
Daniela Ortner ◽  
Daniela Grabher ◽  
Martin Hermann ◽  
Elisabeth Kremmer ◽  
Susanne Hofer ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Mhc Class I ◽  
T Cell Activation ◽  
Cell Activation ◽  
Adaptor Protein ◽  
Cd8 T Cell ◽  
Class I ◽  
Human Dendritic Cells
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