scholarly journals Histone Acetyltransferase Cofactor Trrap Is Essential for Maintaining the Hematopoietic Stem/Progenitor Cell Pool

2009 ◽  
Vol 183 (10) ◽  
pp. 6422-6431 ◽  
Author(s):  
Joanna I. Loizou ◽  
Gabriela Oser ◽  
Vivek Shukla ◽  
Carla Sawan ◽  
Rabih Murr ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Histone Acetyltransferase ◽  
Hematopoietic Stem ◽  
Cell Pool ◽  
Progenitor Cell Pool

scholarly journals Fancd2 and p21 function independently in maintaining the size of hematopoietic stem and progenitor cell pool in mice

2013 ◽  
Vol 11 (2) ◽  
pp. 687-692 ◽  
Author(s):  
Qing-Shuo Zhang ◽  
Kevin Watanabe-Smith ◽  
Kathryn Schubert ◽  
Angela Major ◽  
Andrea M. Sheehan ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Hematopoietic Stem ◽  
Cell Pool ◽  
Progenitor Cell Pool

Oral Administration of Insulin Receptor-Interacting Lectins Leads to an Enhancement in the Hematopoietic Stem and Progenitor Cell Pool of Mice

2010 ◽  
Vol 19 (2) ◽  
pp. 163-174 ◽  
Author(s):  
Ashwini Hinge ◽  
Manmohan Bajaj ◽  
Lalita Limaye ◽  
Avadhesha Surolia ◽  
Vaijayanti Kale
Keyword(s):  
Oral Administration ◽  
Insulin Receptor ◽  
Progenitor Cell ◽  
Hematopoietic Stem ◽  
Cell Pool ◽  
Progenitor Cell Pool

scholarly journals Microgravity influences maintenance of the human muscle stem/progenitor cell pool

2017 ◽  
Vol 493 (2) ◽  
pp. 998-1003 ◽  
Author(s):  
Tohru Hosoyama ◽  
Shunji Ichida ◽  
Masatsugu Kanno ◽  
Reiichi Ishihara ◽  
Toshikatsu Hatashima ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Human Muscle ◽  
Cell Pool ◽  
Progenitor Cell Pool

scholarly journals Kit-Shp2-Kit signaling acts to maintain a functional hematopoietic stem and progenitor cell pool

Blood ◽  
2011 ◽  
Vol 117 (20) ◽  
pp. 5350-5361 ◽  
Author(s):  
Helen He Zhu ◽  
Kaihong Ji ◽  
Nazilla Alderson ◽  
Zhao He ◽  
Shuangwei Li ◽  
...  
Keyword(s):  
Progenitor Cell ◽  
Tyrosine Phosphatase ◽  
Critical Role ◽  
Molecular Signaling ◽  
Hematopoietic Stem ◽  
Kit Gene ◽  
Signaling Axis ◽  
Kinase Cascade ◽  
Progenitor Cell Pool

Abstract The stem cell factor (SCF)/Kit system has served as a classic model in deciphering molecular signaling events in the hematopoietic compartment, and Kit expression is a most critical marker for hematopoietic stem cells (HSCs) and progenitors. However, it remains to be elucidated how Kit expression is regulated in HSCs. Herein we report that a cytoplasmic tyrosine phosphatase Shp2, acting downstream of Kit and other RTKs, promotes Kit gene expression, constituting a Kit-Shp2-Kit signaling axis. Inducible ablation of PTPN11/Shp2 resulted in severe cytopenia in BM, spleen, and peripheral blood in mice. Shp2 removal suppressed the functional pool of HSCs/progenitors, and Shp2-deficient HSCs failed to reconstitute lethally irradiated recipients because of defects in homing, self-renewal, and survival. We show that Shp2 regulates coordinately multiple signals involving up-regulation of Kit expression via Gata2. Therefore, this study reveals a critical role of Shp2 in maintenance of a functional HSC/progenitor pool in adult mammals, at least in part through a kinase-phosphatase-kinase cascade.

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