scholarly journals Cytosolic Aminopeptidases Influence MHC Class I-Mediated Antigen Presentation in an Allele-Dependent Manner

2009 ◽  
Vol 183 (11) ◽  
pp. 7379-7387 ◽  
Author(s):  
Eunkyung Kim ◽  
Heechun Kwak ◽  
Kwangseog Ahn
Keyword(s):  
Antigen Presentation ◽  
Mhc Class I ◽  
Class I ◽  
Dependent Manner

scholarly journals Radiation modulates the peptide repertoire, enhances MHC class I expression, and induces successful antitumor immunotherapy

2006 ◽  
Vol 203 (5) ◽  
pp. 1259-1271 ◽  
Author(s):  
Eric A. Reits ◽  
James W. Hodge ◽  
Carla A. Herberts ◽  
Tom A. Groothuis ◽  
Mala Chakraborty ◽  
...  
Keyword(s):  
Antigen Presentation ◽  
Mhc Class I ◽  
Cytotoxic T Lymphocyte ◽  
Colon Adenocarcinoma ◽  
Peptide Pool ◽  
Class I ◽  
Cell Surface Expression ◽  
Dependent Manner ◽  
Γ Irradiation ◽  
Mhc Class I Molecules

Radiotherapy is one of the most successful cancer therapies. Here the effect of irradiation on antigen presentation by MHC class I molecules was studied. Cell surface expression of MHC class I molecules was increased for many days in a radiation dose-dependent manner as a consequence of three responses. Initially, enhanced degradation of existing proteins occurred which resulted in an increased intracellular peptide pool. Subsequently, enhanced translation due to activation of the mammalian target of rapamycin pathway resulted in increased peptide production, antigen presentation, as well as cytotoxic T lymphocyte recognition of irradiated cells. In addition, novel proteins were made in response to γ-irradiation, resulting in new peptides presented by MHC class I molecules, which were recognized by cytotoxic T cells. We show that immunotherapy is successful in eradicating a murine colon adenocarcinoma only when preceded by radiotherapy of the tumor tissue. Our findings indicate that directed radiotherapy can improve the efficacy of tumor immunotherapy.

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