Reducing Epitope Spread during Affinity Maturation of an Anti-Ganglioside GD2 Antibody

Jian Hu; Xiaodong Huang; Chang-Chun Ling; David R. Bundle; Nai-Kong V. Cheung

doi:10.4049/jimmunol.0901409

Reducing Epitope Spread during Affinity Maturation of an Anti-Ganglioside GD2 Antibody

The Journal of Immunology ◽

10.4049/jimmunol.0901409 ◽

2009 ◽

Vol 183 (9) ◽

pp. 5748-5755 ◽

Cited By ~ 14

Author(s):

Jian Hu ◽

Xiaodong Huang ◽

Chang-Chun Ling ◽

David R. Bundle ◽

Nai-Kong V. Cheung

Keyword(s):

Affinity Maturation ◽

Ganglioside Gd2 ◽

Epitope Spread

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Eczema induces a high ovalbumin-specific IgE/IgG1 ratio and affinity maturation during the lactation period

10.26226/morressier.5acc8ad6d462b8028d89a726 ◽

2018 ◽

Author(s):

Makoto Irahara

Keyword(s):

Specific Ige ◽

Affinity Maturation ◽

Lactation Period

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Faculty Opinions recommendation of Short-lived plasmablasts dominate the early spontaneous rheumatoid factor response: differentiation pathways, hypermutating cell types, and affinity maturation outside the germinal center.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1026200.324963 ◽

2005 ◽

Author(s):

John Kearney

Keyword(s):

Rheumatoid Factor ◽

Germinal Center ◽

Cell Types ◽

Affinity Maturation ◽

Response Differentiation ◽

Differentiation Pathways

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Faculty Opinions recommendation of Lack of antibody affinity maturation due to poor Toll-like receptor stimulation leads to enhanced respiratory syncytial virus disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1146889.604312 ◽

2009 ◽

Author(s):

Richard Vile

Keyword(s):

Respiratory Syncytial Virus ◽

Virus Disease ◽

Affinity Maturation ◽

Toll Like Receptor ◽

Respiratory Syncytial Virus Disease ◽

Antibody Affinity ◽

Receptor Stimulation ◽

Syncytial Virus

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Faculty Opinions recommendation of In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.3077965.2761069 ◽

2010 ◽

Author(s):

David Allman

Keyword(s):

Immune Response ◽

Clonal Selection ◽

Affinity Maturation ◽

Primary Immune Response ◽

In Situ Studies ◽

Two Stages

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Faculty Opinions recommendation of Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.4666956.5590056 ◽

2010 ◽

Author(s):

E Charles Snow

Keyword(s):

Dendritic Cells ◽

Germinal Center ◽

Affinity Maturation ◽

Follicular Dendritic Cells ◽

Toll Like Receptor ◽

Toll Like Receptor 4 ◽

Follicular Dendritic

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Faculty Opinions recommendation of Toll-like receptor 4 signaling by follicular dendritic cells is pivotal for germinal center onset and affinity maturation.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.4666956.4546054 ◽

2010 ◽

Author(s):

Dan Conrad

Keyword(s):

Dendritic Cells ◽

Germinal Center ◽

Affinity Maturation ◽

Follicular Dendritic Cells ◽

Toll Like Receptor ◽

Toll Like Receptor 4 ◽

Follicular Dendritic

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Faculty Opinions recommendation of Visualizing antibody affinity maturation in germinal centers.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726171893.793544262 ◽

2018 ◽

Author(s):

Kai-Michael Toellner ◽

Yang Zhang ◽

Lingling Zhang

Keyword(s):

Germinal Centers ◽

Affinity Maturation ◽

Antibody Affinity

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Faculty Opinions recommendation of Visualizing antibody affinity maturation in germinal centers.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726171893.793518316 ◽

2016 ◽

Author(s):

K Mark Ansel ◽

Dirk Baumjohann

Keyword(s):

Germinal Centers ◽

Affinity Maturation ◽

Antibody Affinity

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Faculty Opinions recommendation of Visualizing antibody affinity maturation in germinal centers.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726171893.793517614 ◽

2016 ◽

Author(s):

Tim Manser

Keyword(s):

Germinal Centers ◽

Affinity Maturation ◽

Antibody Affinity

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Faculty Opinions recommendation of Visualizing antibody affinity maturation in germinal centers.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726171893.793516165 ◽

2016 ◽

Author(s):

Hui Hu

Keyword(s):

Germinal Centers ◽

Affinity Maturation ◽

Antibody Affinity

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