scholarly journals Selectively Reduced Intracellular Proliferation ofSalmonella entericaSerovar Typhimurium within APCs Limits Antigen Presentation and Development of a Rapid CD8 T Cell Response

2009 ◽  
Vol 183 (6) ◽  
pp. 3778-3787 ◽  
Author(s):  
Homam Albaghdadi ◽  
Nirmal Robinson ◽  
Brett Finlay ◽  
Lakshmi Krishnan ◽  
Subash Sad
Keyword(s):  
T Cell ◽  
Antigen Presentation ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Intracellular Proliferation

scholarly journals Peptide Vaccine Formulation Controls the Duration of Antigen Presentation and Magnitude of Tumor-Specific CD8+ T Cell Response

2018 ◽  
Vol 200 (10) ◽  
pp. 3464-3474 ◽  
Author(s):  
Hiep Khong ◽  
Annika Volmari ◽  
Meenu Sharma ◽  
Zhimin Dai ◽  
Chinonye S. Imo ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Presentation ◽  
Cell Response ◽  
Peptide Vaccine ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Vaccine Formulation

scholarly journals Differential Antigen Presentation Regulates the Changing Patterns of CD8+ T Cell Immunodominance in Primary and Secondary Influenza Virus Infections

2003 ◽  
Vol 198 (3) ◽  
pp. 399-410 ◽  
Author(s):  
Sherry R. Crowe ◽  
Stephen J. Turner ◽  
Shannon C. Miller ◽  
Alan D. Roberts ◽  
Rachel A. Rappolo ◽  
...  
Keyword(s):  
T Cells ◽  
Influenza Virus ◽  
T Cell ◽  
Virus Infection ◽  
Antigen Presentation ◽  
Cd8 T Cells ◽  
Cell Response ◽  
Influenza Virus Infection ◽  
Cd8 T Cell ◽  
T Cell Response

The specificity of CD8+ T cell responses can vary dramatically between primary and secondary infections. For example, NP366–374/Db- and PA224–233/Db-specific CD8+ T cells respond in approximately equal numbers to a primary influenza virus infection in C57BL/6 mice, whereas NP366–374/Db-specific CD8+ T cells dominate the secondary response. To investigate the mechanisms underlying this changing pattern of immunodominance, we analyzed the role of antigen presentation in regulating the specificity of the T cell response. The data show that both dendritic and nondendritic cells are able to present the NP366–374/Db epitope, whereas only dendritic cells effectively present the PA224–233/Db epitope after influenza virus infection, both in vitro and in vivo. This difference in epitope expression favored the activation and expansion of NP366–374/Db-specific CD8+ memory T cells during secondary infection. The data also show that the immune response to influenza virus infection may involve T cells specific for epitopes, such as PA224–233/Db, that are poorly expressed at the site of infection. In this regard, vaccination with the PA224–233 peptide actually had a detrimental effect on the clearance of a subsequent influenza virus infection. Thus, differential antigen presentation impacts both the specificity of the T cell response and the efficacy of peptide-based vaccination strategies.

scholarly journals Murine Cytomegalovirus Interference with Antigen Presentation Has Little Effect on the Size or the Effector Memory Phenotype of the CD8 T Cell Response

2004 ◽  
Vol 172 (11) ◽  
pp. 6944-6953 ◽  
Author(s):  
Marielle C. Gold ◽  
Michael W. Munks ◽  
Markus Wagner ◽  
Christopher W. McMahon ◽  
Ann Kelly ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Presentation ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Murine Cytomegalovirus ◽  
Effector Memory ◽  
Memory Phenotype

Heparan sulfates targeting increases MHC class I- and MHC class II-restricted antigen presentation and CD8 + T-cell response

Vaccine ◽  
2016 ◽  
Vol 34 (27) ◽  
pp. 3093-3101 ◽  
Author(s):  
Delphine Knittel ◽  
Adeline Gadzinski ◽  
Stéphane Hua ◽  
Jordan Denizeau ◽  
Alexandra Savatier ◽  
...  
Keyword(s):  
T Cell ◽  
Antigen Presentation ◽  
Mhc Class I ◽  
Mhc Class Ii ◽  
Cell Response ◽  
Cd8 T Cell ◽  
Class Ii ◽  
T Cell Response ◽  
Class I ◽  
Heparan Sulfates
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