scholarly journals The Development and Function of Regulatory B Cells Expressing IL-10 (B10 Cells) Requires Antigen Receptor Diversity and TLR Signals

2009 ◽  
Vol 182 (12) ◽  
pp. 7459-7472 ◽  
Author(s):  
Koichi Yanaba ◽  
Jean-David Bouaziz ◽  
Takashi Matsushita ◽  
Takeshi Tsubata ◽  
Thomas F. Tedder
Keyword(s):  
B Cells ◽  
Antigen Receptor ◽  
Regulatory B Cells ◽  
And Function ◽  
B10 Cells

scholarly journals Immunosuppressive Mechanisms of Regulatory B Cells

2021 ◽  
Vol 12 ◽  
Author(s):  
Diego Catalán ◽  
Miguel Andrés Mansilla ◽  
Ashley Ferrier ◽  
Lilian Soto ◽  
Kristine Oleinika ◽  
...  
Keyword(s):  
B Cells ◽  
Immune Responses ◽  
Metabolic Diseases ◽  
Inflammatory Responses ◽  
Surface Proteins ◽  
Regulatory B Cells ◽  
Cell Surface Proteins ◽  
The Past ◽  
And Function

Regulatory B cells (Bregs) is a term that encompasses all B cells that act to suppress immune responses. Bregs contribute to the maintenance of tolerance, limiting ongoing immune responses and reestablishing immune homeostasis. The important role of Bregs in restraining the pathology associated with exacerbated inflammatory responses in autoimmunity and graft rejection has been consistently demonstrated, while more recent studies have suggested a role for this population in other immune-related conditions, such as infections, allergy, cancer, and chronic metabolic diseases. Initial studies identified IL-10 as the hallmark of Breg function; nevertheless, the past decade has seen the discovery of other molecules utilized by human and murine B cells to regulate immune responses. This new arsenal includes other anti-inflammatory cytokines such IL-35 and TGF-β, as well as cell surface proteins like CD1d and PD-L1. In this review, we examine the main suppressive mechanisms employed by these novel Breg populations. We also discuss recent evidence that helps to unravel previously unknown aspects of the phenotype, development, activation, and function of IL-10-producing Bregs, incorporating an overview on those questions that remain obscure.

scholarly journals Potential Role for Regulatory B Cells as a Major Source of Interleukin-10 in Spleen fromPlasmodium chabaudi-Infected Mice

2018 ◽  
Vol 86 (5) ◽  
Author(s):  
Xue Han ◽  
Ji Yang ◽  
Yitong Zhang ◽  
Yalin Zhang ◽  
Hongtao Cao ◽  
...  
Keyword(s):  
Immune Response ◽  
B Cells ◽  
Potential Role ◽  
Interleukin 10 ◽  
Surface Markers ◽  
Regulatory B Cells ◽  
Plasmodium Chabaudi ◽  
Impact On Survival ◽  
And Function ◽  
Stimulation Of

ABSTRACTInterleukin-10 (IL-10)-producing regulatory B (Breg) cells were found to be induced in a variety of infectious diseases. However, its importance in the regulation of immune response to malaria is still unclear. Here, we investigated the dynamics, phenotype, and function of Breg cells usingPlasmodium chabaudi chabaudiAS-infected C57BL/6 and BALB/c mice. BALB/c mice were more susceptible to infection and had a stronger IL-10 response in spleen than C57BL/6 mice. Analysis of the surface markers of IL-10-producing cells with flow cytometry showed that CD19+B cells were one of the primary IL-10-producing populations inP. c. chabaudiAS-infected C57BL/6 and BALB/c mice, especially in the latter one. The Breg cells had a heterogeneous phenotype which shifted during infection. The well-established Breg subset, CD19+CD5+CD1dhicells, accounted for less than 20% of IL-10-producing B cells in both strains during the course of infection. Most Breg cells were IgG+and CD138−from day 0 to day 8 postinfection. Adoptive transfer of Breg cells to C57BL/6 mice infected withP. c. chabaudiAS led to a transient increase of parasitemia without an impact on survival rate. Our finding reveals that B cells play an active and important regulatory role in addition to mediating humoral immunity in immune response against malaria, which should be paid more attention in developing therapeutic or vaccine strategies against malaria involving stimulation of B cells.

scholarly journals IL-10-producing regulatory B cells (B10 cells) in autoimmune disease

2013 ◽  
Vol 15 (Suppl 1) ◽  
pp. S1 ◽  
Author(s):  
Ioannis Kalampokis ◽  
Ayumi Yoshizaki ◽  
Thomas F Tedder
Keyword(s):  
B Cells ◽  
Autoimmune Disease ◽  
Regulatory B Cells ◽  
B10 Cells

scholarly journals Peritoneal Cavity Regulatory B Cells (B10 Cells) Modulate IFN-γ+CD4+ T Cell Numbers during Colitis Development in Mice

2013 ◽  
Vol 191 (5) ◽  
pp. 2780-2795 ◽  
Author(s):  
Damian Maseda ◽  
Kathleen M. Candando ◽  
Susan H. Smith ◽  
Ioannis Kalampokis ◽  
Casey T. Weaver ◽  
...  
Keyword(s):  
T Cell ◽  
B Cells ◽  
Peritoneal Cavity ◽  
Cd4 T Cell ◽  
Regulatory B Cells ◽  
Cell Numbers ◽  
Ifn Γ ◽  
B10 Cells

scholarly journals The Emerging Potentials of Human Regulatory B Cells Mediated Therapies in Myasthenia Gravis

2020 ◽  
Author(s):  
Md Rezaul Karim
Keyword(s):  
B Cells ◽  
Myasthenia Gravis ◽  
Immune Tolerance ◽  
Therapeutic Strategies ◽  
Regulatory B Cells ◽  
Chronic Infections ◽  
Pros And Cons ◽  
And Function ◽  
Negative Regulatory Role

Regulatory B cells (Bregs) with immunosuppressive function are critical in maintaining immune tolerance. In recent years, Bregs is an essential part of the study due to its therapeutic relevance and function in immune tolerance. The positive and negative regulatory role of human Bregs in immune tolerance is being discussed in several pathologies, including in autoimmune diseases, cancers, chronic infections, strokes in multiple reports. The negative regulatory roles of human Bregs are associated with lesser numbers and functional abnormalities in most of these studies, including myasthenia gravis (MG). In this review, the potential findings regarding human Bregs in MG, and Bregs mediated potential therapeutic strategies with its pros and cons have been discussed based on previous and current reports.

Apremilast increases IL-10-producing regulatory B cells and decreases proinflammatory T cells and innate cells in psoriatic arthritis and psoriasis

Rheumatology ◽  
2019 ◽  
Vol 58 (12) ◽  
pp. 2240-2250 ◽  
Author(s):  
Athanasios Mavropoulos ◽  
Efterpi Zafiriou ◽  
Theodora Simopoulou ◽  
Alexandros G Brotis ◽  
Christos Liaskos ◽  
...  
Keyword(s):  
Psoriatic Arthritis ◽  
B Cells ◽  
Cell Subset ◽  
Nkt Cells ◽  
Pde4 Inhibitor ◽  
Psoriatic Skin ◽  
Th1 Cells ◽  
Regulatory B Cells ◽  
Immunological Mechanisms ◽  
B10 Cells

Abstract Objectives Psoriatic arthritis (PsA) and psoriasis are immune-mediated inflammatory diseases sharing common immunological mechanisms. Regulatory B cells (Breg cells) producing IL–10 (B10 cells), a critical anti-inflammatory B-cell subset, were found to be decreased in both PsA and psoriasis. Apremilast, a phosphodiesterase-4(PDE4) inhibitor, increases IL-10 and therefore, we examined the effect of apremilast on Breg cells. Methods Fifty patients, including 20 with PsA and 30 with psoriasis, were included in the study. The effect of apremilast on Breg cells at 3, 6 and 12 months post-treatment, was examined by flow cytometry in ODN2006 (TLR9)-stimulated peripheral blood mononuclear cells and magnetically-isolated cells. Th1 cells, Th17 cells and NKT were also measured. Results Ex vivo stimulated cell analysis identified that post-apremilast (IL-10+CD19+) B10 cells were increased in all PsA and psoriasis patients and correlated with psoriatic skin and joint clinical improvement. Apremilast decreased IFNγ(+) T and NKT cells and IL-17(+)NKT cells. B10 cells also inversely correlated with Th1 cells, and IFNγ(+)NKT cells. Conclusion These results suggest that Breg cells are a major target of apremilast in PsA and psoriasis and that apremilast-induced increase of Breg cells is associated with a decrease of Th1 cells, IFNγ-producing NKT cells and IL-17-producing NKT cells.

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