scholarly journals CTLA4Ig Alters the Course of Autoimmune Disease Development in Lyn−/− Mice

2009 ◽  
Vol 184 (2) ◽  
pp. 757-763 ◽  
Author(s):  
Sarah A. Oracki ◽  
Evelyn Tsantikos ◽  
Cathy Quilici ◽  
Amanda Light ◽  
Thomas Schmidt ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Disease Development

scholarly journals Individuals at risk for developing rheumatoid arthritis harbor differential intestinal bacteriophage communities with distinct metabolic potential

2021 ◽  
Author(s):  
Mihnea R. Mangalea ◽  
David Paez-Espino ◽  
Kristopher Kieft ◽  
Anushila Chatterjee ◽  
Jennifer A. Seifert ◽  
...  
Keyword(s):  
Rheumatoid Arthritis ◽  
At Risk ◽  
Autoimmune Disease ◽  
Intestinal Microbiota ◽  
Disease Development ◽  
Metabolic Potential ◽  
Metabolic Genes ◽  
Auxiliary Metabolic Genes ◽  
Citrullinated Protein ◽  
Insight Into

SUMMARYRheumatoid arthritis (RA) is an autoimmune disease characterized in seropositive individuals by the presence of anti-cyclic citrullinated protein (CCP) antibodies. RA is linked to the intestinal microbiota, yet the association of microbes with CCP serology and their contribution to RA is unclear. We describe intestinal phage communities of individuals at risk for developing RA, with or without anti-CCP antibodies, whose first degree relatives have been diagnosed with RA. We show that at-risk individuals harbor intestinal phage compositions that diverge based on CCP serology, are dominated by Lachnospiraceae phages, and originate from disparate ecosystems. These phages encode unique repertoires of auxiliary metabolic genes (AMGs) which associate with anti-CCP status, suggesting that these phages directly influence the metabolic and immunomodulatory capability of the microbiota. This work sets the stage for the use of phages as preclinical biomarkers and provides insight into a possible microbial-based causation of RA disease development.

scholarly journals Deficiency in T follicular regulatory cells promotes autoimmunity

2018 ◽  
Vol 215 (3) ◽  
pp. 815-825 ◽  
Author(s):  
Weiwei Fu ◽  
Xindong Liu ◽  
Xiang Lin ◽  
Han Feng ◽  
Lin Sun ◽  
...  
Keyword(s):  
Influenza Virus ◽  
Autoimmune Disease ◽  
Autoimmune Diseases ◽  
Germinal Center ◽  
Physiological Function ◽  
Late Onset ◽  
Humoral Response ◽  
Disease Development ◽  
Lymphocyte Infiltration ◽  
Regulatory Cells

T follicular regulatory (Tfr) cells are a new subset of regulatory T (T reg) cells localized in the germinal center to limit the humoral response. Until now, the physiological function of Tfr cells has been largely unknown. In this study, we developed a Bcl6fl/flFoxp3Cre mouse to analyze the function of Tfr cells in immune and autoimmune responses. These mice exhibited enhanced immunity to influenza virus; moreover, Bcl6fl/flFoxp3Cre/Cre mice developed late-onset spontaneous autoimmune diseases, affecting the salivary glands with lymphocyte infiltration and antibody deposition. In a mouse experimental Sjögren’s syndrome model, ablation of Bcl6 in T reg cells greatly enhanced disease development. Conversely, Bcl6fl/flCd4Cre mice were protected in the model. Thus, our study indicates that Tfr cells control autoimmune diseases and can be targeted in infectious and autoimmune disease.

Cell cycle of bone marrow CD34+ cells during autoimmune disease development in MRLMpJ/lpr mice

2006 ◽  
Vol 142 (1) ◽  
pp. 137-139
Author(s):  
N. A. Feofanova ◽  
L. B. Toporkova ◽  
M. A. Tikhonova ◽  
G. A. Nevinskii ◽  
V. A. Kozlov ◽  
...  
Keyword(s):  
Cell Cycle ◽  
Bone Marrow ◽  
Autoimmune Disease ◽  
Disease Development ◽  
Cd34 Cells

scholarly journals Quantifying the Role of Stochasticity in the Development of Autoimmune Disease

Cells ◽  
2020 ◽  
Vol 9 (4) ◽  
pp. 860
Author(s):  
Lindsay B. Nicholson ◽  
Konstantin B. Blyuss ◽  
Farzad Fatehi
Keyword(s):  
Autoimmune Disease ◽  
Normal Cell ◽  
Cell Populations ◽  
Disease Development ◽  
Stochastic Effects ◽  
Periodic Oscillations ◽  
Dynamics Stability ◽  
Theoretical Results ◽  
Experimental Autoimmune

In this paper, we propose and analyse a mathematical model for the onset and development of autoimmune disease, with particular attention to stochastic effects in the dynamics. Stability analysis yields parameter regions associated with normal cell homeostasis, or sustained periodic oscillations. Variance of these oscillations and the effects of stochastic amplification are also explored. Theoretical results are complemented by experiments, in which experimental autoimmune uveoretinitis (EAU) was induced in B10.RIII and C57BL/6 mice. For both cases, we discuss peculiarities of disease development, the levels of variation in T cell populations in a population of genetically identical organisms, as well as a comparison with model outputs.

scholarly journals Mast Cells in Early Rheumatoid Arthritis

2019 ◽  
Vol 20 (8) ◽  
pp. 2040 ◽  
Author(s):  
Felice Rivellese ◽  
Francesca Wanda Rossi ◽  
Maria Rosaria Galdiero ◽  
Costantino Pitzalis ◽  
Amato de Paulis
Keyword(s):  
Rheumatoid Arthritis ◽  
Innate Immunity ◽  
Mast Cells ◽  
Autoimmune Disease ◽  
Animal Models ◽  
Immune Cells ◽  
Systemic Autoimmune Disease ◽  
Disease Development ◽  
Early Ra ◽  
Contradictory Data

Rheumatoid arthritis (RA) is a chronic systemic autoimmune disease characterized by inflammation of the synovial membrane, with thickening of the synovial layer, cellular hyperplasia, and infiltration of immune cells. Mast cells (MCs) are cells of the innate immunity present in healthy synovia and part of the cellular hyperplasia characterizing RA synovitis. Although their presence in synovia has been well described, the exact functions and the correlation of MCs with disease development and progression have been debated, particularly because of contradictory data obtained in animal models and from patients with longstanding disease. Here, we present a revision of the literature on MCs in RA, including the most recent observations obtained from patients with early RA, indicating MCs as relevant markers of disease severity in early RA.

scholarly journals The Potential Roles of Bisphenol A (BPA) Pathogenesis in Autoimmunity

2014 ◽  
Vol 2014 ◽  
pp. 1-12 ◽  
Author(s):  
Datis Kharrazian
Keyword(s):  
Autoimmune Disease ◽  
Bisphenol A ◽  
Molecular Mimicry ◽  
Signal Transduction Pathway ◽  
Immune Reactivity ◽  
Cytochrome P450 Enzyme ◽  
Disease Development ◽  
Aryl Hydrocarbon ◽  
P450 Enzyme ◽  
The Impact

Bisphenol A (BPA) is a monomer found in commonly used consumer plastic goods. Although much attention in recent years has been placed on BPA’s impact as an endocrine disruptor, it also appears to activate many immune pathways involved in both autoimmune disease development and autoimmune reactivity provocation. The current scientific literature is void of research papers linking BPA directly to human or animal onset of autoimmunity. This paper explores the impact of BPA on immune reactivity and the potential roles these mechanisms may have on the development or provocation of autoimmune diseases. Potential mechanisms by which BPA may be a contributing risk factor to autoimmune disease development and progression include its impact on hyperprolactinemia, estrogenic immune signaling, cytochrome P450 enzyme disruption, immune signal transduction pathway alteration, cytokine polarization, aryl hydrocarbon activation of Th-17 receptors, molecular mimicry, macrophage activation, lipopolysaccharide activation, and immunoglobulin pathophysiology. In this paper a review of these known autoimmune triggering mechanisms will be correlated with BPA exposure, thereby suggesting that BPA has a role in the pathogenesis of autoimmunity.

scholarly journals Dermatomyositis‐lupus overlap syndrome complicated with cardiomyopathy after SARS‐CoV‐2 infection: A new potential trigger for musculoskeletal autoimmune disease development

2021 ◽  
Vol 9 (10) ◽  
Author(s):  
Mohammad Shahidi Dadras ◽  
Azadeh Rakhshan ◽  
Arman Ahmadzadeh ◽  
Seyed Ali Hosseini ◽  
Reem Diab ◽  
...  
Keyword(s):  
Autoimmune Disease ◽  
Overlap Syndrome ◽  
Disease Development ◽  
Potential Trigger
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