scholarly journals Fatty Acyl Structures of Mycobacterium tuberculosis Sulfoglycolipid Govern T Cell Response

2009 ◽  
Vol 182 (11) ◽  
pp. 7030-7037 ◽  
Author(s):  
Julie Guiard ◽  
Anthony Collmann ◽  
Luis Fernando Garcia-Alles ◽  
Lionel Mourey ◽  
Thérèse Brando ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cell Response ◽  
Fatty Acyl ◽  
T Cell Response

T Cell Response to Mycobacterium tuberculosis

1993 ◽  
Vol 167 (6) ◽  
pp. 1481-1497 ◽  
Author(s):  
I. M. Orme ◽  
P. Andersen ◽  
W. H. Boom
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response

scholarly journals An unbiased peptide-wide discovery approach to select Mycobacterium tuberculosis antigens that target CD8+ T cell response during infection

Vaccine ◽  
2013 ◽  
Vol 31 (42) ◽  
pp. 4834-4840 ◽  
Author(s):  
Mark J. Cayabyab ◽  
Lizeng Qin ◽  
Suely S. Kashino ◽  
Angelo Izzo ◽  
Antonio Campos-Neto
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response

scholarly journals Higher human CD4 T cell response to novel Mycobacterium tuberculosis latency associated antigens Rv2660 and Rv2659 in latent infection compared with tuberculosis disease

Vaccine ◽  
2010 ◽  
Vol 29 (1) ◽  
pp. 51-57 ◽  
Author(s):  
Lerisa Govender ◽  
Brian Abel ◽  
E. Jane Hughes ◽  
Thomas J. Scriba ◽  
Benjamin M.N. Kagina ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cell Response ◽  
Latent Infection ◽  
T Cell Response ◽  
Cd4 T Cell ◽  
Tuberculosis Disease

scholarly journals Promiscuous Peptide of 16 kDa Antigen Linked to Pam2Cys Protects Against Mycobacterium tuberculosis by Evoking Enduring Memory T-Cell Response

2011 ◽  
Vol 204 (9) ◽  
pp. 1328-1338 ◽  
Author(s):  
Uthaman Gowthaman ◽  
Vijender Singh ◽  
Weiguang Zeng ◽  
Shweta Jain ◽  
Kaneez F. Siddiqui ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cell Response ◽  
T Cell Response ◽  
Memory T Cell ◽  
Promiscuous Peptide

scholarly journals Bacterial Protein Secretion Is Required for Priming of CD8+ T Cells Specific for the Mycobacterium tuberculosis Antigen CFP10

2008 ◽  
Vol 76 (9) ◽  
pp. 4199-4205 ◽  
Author(s):  
Joshua S. Woodworth ◽  
Sarah M. Fortune ◽  
Samuel M. Behar
Keyword(s):  
T Cells ◽  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cell Response ◽  
Vaccine Development ◽  
T Cell Response ◽  
Class I Mhc ◽  
Mhc I ◽  
Mycobacterial Antigens

ABSTRACT Mycobacterium tuberculosis infection elicits antigen-specific CD8+ T cells that are required to control disease. It is unknown how the major histocompatibility complex class I (MHC-I) pathway samples mycobacterial antigens. CFP10 and ESAT6 are important virulence factors secreted by M. tuberculosis, and they are immunodominant targets of the human and murine T-cell response. Here, we test the hypothesis that CFP10 secretion by M. tuberculosis is required for the priming of CD8+ T cells in vivo. Our results reveal an explicit dependence upon the bacterial secretion of the CFP10 antigen for the induction of antigen-specific CD8+ T cells in vivo. By using well-defined M. tuberculosis mutants and carefully controlling for virulence, we show that ESX-1 function is required for the priming of CD8+ T cells specific for CFP10. CD4+ and CD8+ T-cell responses to mycobacterial antigens secreted independently of ESX-1 were unaffected, suggesting that ESX-1-dependent phagosomal escape is not required for CD8+ T-cell priming during infection. We propose that the overrepresentation of secreted proteins as dominant targets of the CD8+ T-cell response during M. tuberculosis infection is a consequence of their preferential sampling by the MHC-I pathway. The implications of these findings should be considered in all models of antigen presentation during M. tuberculosis infection and in vaccine development.

Enhancement of the human T cell response to culture filtrate fractions of Mycobacterium tuberculosis by microspheres

2000 ◽  
Vol 235 (1-2) ◽  
pp. 1-9 ◽  
Author(s):  
Katalin A Wilkinson ◽  
John T Belisle ◽  
Maria Mincek ◽  
Robert J Wilkinson ◽  
Zahra Toossi
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Culture Filtrate ◽  
Cell Response ◽  
T Cell Response ◽  
Human T Cell

scholarly journals A natural polymorphism of Mycobacterium tuberculosis in the esxH gene disrupts immunodomination by the TB10.4-specific CD8 T cell response

2020 ◽  
Vol 16 (10) ◽  
pp. e1009000
Author(s):  
Rujapak Sutiwisesak ◽  
Nathan D. Hicks ◽  
Shayla Boyce ◽  
Kenan C. Murphy ◽  
Kadamba Papavinasasundaram ◽  
...  
Keyword(s):  
Mycobacterium Tuberculosis ◽  
T Cell ◽  
Cell Response ◽  
Cd8 T Cell ◽  
T Cell Response ◽  
Natural Polymorphism
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