scholarly journals FROUNT Is a Common Regulator of CCR2 and CCR5 Signaling to Control Directional Migration

2009 ◽  
Vol 183 (10) ◽  
pp. 6387-6394 ◽  
Author(s):  
Etsuko Toda ◽  
Yuya Terashima ◽  
Tsuyoshi Sato ◽  
Kenzo Hirose ◽  
Shiro Kanegasaki ◽  
...  
Keyword(s):  
Directional Migration ◽  
Common Regulator

Metabolic Syndrome and Aging: Calcium Signaling as Common Regulator

2015 ◽  
Vol 12 (2) ◽  
pp. 84-89 ◽  
Author(s):  
Maria Soprano ◽  
Maria Rosaria Rusciano ◽  
Michele Ciccarelli ◽  
Angela Serena Maione ◽  
Pietro Formisano ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Calcium Signaling ◽  
Common Regulator

Effects of directional migration for pursuit of profitable circumstances in evolutionary games

2021 ◽  
Vol 144 ◽  
pp. 110709
Author(s):  
Lan Zhang ◽  
Changwei Huang ◽  
Haihong Li ◽  
Qionglin Dai ◽  
Junzhong Yang
Keyword(s):  
Evolutionary Games ◽  
Directional Migration

Bi-directional migration of lens epithelial cells in a physiological electrical field

2003 ◽  
Vol 76 (1) ◽  
pp. 29-37 ◽  
Author(s):  
Entong Wang ◽  
Min Zhao ◽  
John V. Forrester ◽  
Colin D. McCaig
Keyword(s):  
Epithelial Cells ◽  
Lens Epithelial Cells ◽  
Directional Migration ◽  
Electrical Field

scholarly journals α-Synuclein, a chemoattractant, directs microglial migration via H2O2-dependent Lyn phosphorylation

2015 ◽  
Vol 112 (15) ◽  
pp. E1926-E1935 ◽  
Author(s):  
Shijun Wang ◽  
Chun-Hsien Chu ◽  
Tessandra Stewart ◽  
Carmen Ginghina ◽  
Yifei Wang ◽  
...  
Keyword(s):  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Cell Migration ◽  
Neuronal Damage ◽  
Directional Migration ◽  
Chronic Neuroinflammation ◽  
Tyrosine Protein Kinase ◽  
Microglial Migration ◽  
Directional Cell Migration ◽  
Cytoskeleton Rearrangement

Malformed α-Synuclein (α-syn) aggregates in neurons are released into the extracellular space, activating microglia to induce chronic neuroinflammation that further enhances neuronal damage in α-synucleinopathies, such as Parkinson’s disease. The mechanisms by which α-syn aggregates activate and recruit microglia remain unclear, however. Here we show that α-syn aggregates act as chemoattractants to direct microglia toward damaged neurons. In addition, we describe a mechanism underlying this directional migration of microglia. Specifically, chemotaxis occurs when α-syn binds to integrin CD11b, leading to H2O2 production by NADPH oxidase. H2O2 directly attracts microglia via a process in which extracellularly generated H2O2 diffuses into the cytoplasm and tyrosine protein kinase Lyn, phosphorylates the F-actin–associated protein cortactin after sensing changes in the microglial intracellular concentration of H2O2. Finally, phosphorylated cortactin mediates actin cytoskeleton rearrangement and facilitates directional cell migration. These findings have significant implications, given that α-syn–mediated microglial migration reaches beyond Parkinson’s disease.

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