Targeting Gut T Cell Ca2+ Release-Activated Ca2+ Channels Inhibits T Cell Cytokine Production and T-Box Transcription Factor T-Bet in Inflammatory Bowel Disease

Antonio Di Sabatino; Laura Rovedatti; Rejbinder Kaur; Jonathan P. Spencer; Jon T. Brown; Valerie D. Morisset; Paolo Biancheri; Nicholas A. B. Leakey; Jonathan I. Wilde; Laurie Scott; Gino R. Corazza; Kevin Lee; Neel Sengupta; Charles H. Knowles; Martin J. Gunthorpe; Peter G. McLean; Thomas T. MacDonald; Laurens Kruidenier

doi:10.4049/jimmunol.0802887

Targeting Gut T Cell Ca2+ Release-Activated Ca2+ Channels Inhibits T Cell Cytokine Production and T-Box Transcription Factor T-Bet in Inflammatory Bowel Disease

The Journal of Immunology ◽

10.4049/jimmunol.0802887 ◽

2009 ◽

Vol 183 (5) ◽

pp. 3454-3462 ◽

Cited By ~ 69

Author(s):

Antonio Di Sabatino ◽

Laura Rovedatti ◽

Rejbinder Kaur ◽

Jonathan P. Spencer ◽

Jon T. Brown ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Transcription Factor ◽

T Cell ◽

Bowel Disease ◽

Cytokine Production ◽

T Box ◽

Inflammatory Bowel ◽

Ca2 Channels ◽

Cell Cytokine Production

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Faculty Opinions recommendation of Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits T cell cytokine production and T-box transcription factor T-bet in inflammatory bowel disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.1383965.856064 ◽

2010 ◽

Author(s):

Indu Ambudkar ◽

Hwei Ling Ong

Keyword(s):

Inflammatory Bowel Disease ◽

Transcription Factor ◽

T Cell ◽

Bowel Disease ◽

Cytokine Production ◽

T Box ◽

Inflammatory Bowel ◽

Ca2 Channels ◽

Cell Cytokine Production

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2 - Targeting gut T cell Ca2+ release-activated Ca2+ channels inhibits Th1 cytokine production and T-box transcription factor T-bet in inflammatory bowel disease

Journal of Crohn s and Colitis ◽

10.1016/s1873-9946(09)60014-3 ◽

2009 ◽

Vol 3 (1) ◽

pp. S3

Author(s):

A. Di Sabatino ◽

L. Rovedatti ◽

R. Kaur ◽

J.P. Spencer ◽

J.I. Wilde ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

Transcription Factor ◽

T Cell ◽

Bowel Disease ◽

Cytokine Production ◽

T Box ◽

Th1 Cytokine ◽

Inflammatory Bowel ◽

Ca2 Channels

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193 ROCK2 Activity Is Highly Increased in Inflammatory Bowel Disease and Facilitates CD4+ T-Cell-Dependent Cytokine Production and Migration

Gastroenterology ◽

10.1016/s0016-5085(16)30294-3 ◽

2016 ◽

Vol 150 (4) ◽

pp. S50-S51

Author(s):

Wenjing Yang ◽

Mingming Sun ◽

Zhanju Liu

Keyword(s):

Inflammatory Bowel Disease ◽

T Cell ◽

Bowel Disease ◽

Cytokine Production ◽

Cd4 T Cell ◽

Inflammatory Bowel ◽

And Migration

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IL-15 Is Highly Expressed in Inflammatory Bowel Disease and Regulates Local T Cell-Dependent Cytokine Production

The Journal of Immunology ◽

10.4049/jimmunol.164.7.3608 ◽

2000 ◽

Vol 164 (7) ◽

pp. 3608-3615 ◽

Cited By ~ 121

Author(s):

Zhanju Liu ◽

Karel Geboes ◽

Stefaan Colpaert ◽

Geert R. D’Haens ◽

Paul Rutgeerts ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

T Cell ◽

Bowel Disease ◽

Cytokine Production ◽

Inflammatory Bowel

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OC3.03.1 T-CELL SELECTIVE INHIBITION OF GUT PRO-INFLAMMATORY CYTOKINE PRODUCTION BY A CA2+ RELEASE-ACTIVATED CA2+ CHANNEL (CRAC) BLOCKER IN INFLAMMATORY BOWEL DISEASE (IBD)

Digestive and Liver Disease ◽

10.1016/s1590-8658(08)60106-1 ◽

2008 ◽

Vol 40 ◽

pp. S41-S42

Author(s):

A. Di Sabatino ◽

L. Kruidenier ◽

L. Rovedatti ◽

N. Leakey ◽

M. Wilson ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

T Cell ◽

Bowel Disease ◽

Inflammatory Cytokine ◽

Cytokine Production ◽

Selective Inhibition ◽

Inflammatory Cytokine Production ◽

Inflammatory Bowel

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Characterization of Helicobacter-induced inflammatory bowel disease in IL-10 -/- and T cell deficient mice

Gastroenterology ◽

10.1016/s0016-5085(01)82599-3 ◽

2001 ◽

Vol 120 (5) ◽

pp. A523-A523

Author(s):

A BURICH ◽

R HERSHBERG ◽

K WAGGIE ◽

W ZENG ◽

J VINEY ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

T Cell ◽

Bowel Disease ◽

Inflammatory Bowel ◽

Deficient Mice

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Faculty Opinions recommendation of The ubiquitin ligase adaptor Ndfip1 regulates T cell-mediated gastrointestinal inflammation and inflammatory bowel disease susceptibility.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.5918956.5911054 ◽

2010 ◽

Author(s):

Sharad Kumar

Keyword(s):

Inflammatory Bowel Disease ◽

T Cell ◽

Ubiquitin Ligase ◽

Bowel Disease ◽

Disease Susceptibility ◽

Inflammatory Bowel ◽

Gastrointestinal Inflammation

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Faculty Opinions recommendation of A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease.

Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature ◽

10.3410/f.726864074.793526490 ◽

2016 ◽

Author(s):

Noam Harpaz ◽

Alexandros Polydorides

Keyword(s):

Inflammatory Bowel Disease ◽

T Cell ◽

Bowel Disease ◽

Pathogenic Role ◽

Inflammatory Bowel

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A mimic of inflammatory bowel disease – a case report of monomorphic epitheliotropic intestinal T-cell lymphoma

Pathology ◽

10.1016/j.pathol.2021.06.046 ◽

2021 ◽

Vol 53 ◽

pp. S32

Author(s):

Brook Lee ◽

Tamadur Mahasneh

Keyword(s):

Inflammatory Bowel Disease ◽

Case Report ◽

T Cell ◽

Bowel Disease ◽

Cell Lymphoma ◽

T Cell Lymphoma ◽

Inflammatory Bowel

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Core Fucosylation on T Cells, Required for Activation of T-Cell Receptor Signaling and Induction of Colitis in Mice, Is Increased in Patients With Inflammatory Bowel Disease

Gastroenterology ◽

10.1053/j.gastro.2016.03.002 ◽

2016 ◽

Vol 150 (7) ◽

pp. 1620-1632 ◽

Cited By ~ 39

Author(s):

Hironobu Fujii ◽

Shinichiro Shinzaki ◽

Hideki Iijima ◽

Kana Wakamatsu ◽

Chizuru Iwamoto ◽

...

Keyword(s):

Inflammatory Bowel Disease ◽

T Cells ◽

T Cell ◽

T Cell Receptor ◽

Bowel Disease ◽

Cell Receptor ◽

T Cell Receptor Signaling ◽

Inflammatory Bowel ◽

Core Fucosylation ◽

Cell Receptor Signaling

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