scholarly journals The Role of ICOS in Directing T Cell Responses: ICOS-Dependent Induction of T Cell Anergy by Tolerogenic Dendritic Cells

2009 ◽  
Vol 182 (6) ◽  
pp. 3349-3356 ◽  
Author(s):  
Andrea Tuettenberg ◽  
Eva Huter ◽  
Mario Hubo ◽  
Julia Horn ◽  
Jürgen Knop ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Cell Responses ◽  
T Cell Anergy ◽  
Tolerogenic Dendritic Cells ◽  
Cell Anergy

Graphene quantum dots suppress proinflammatory T cell responses via autophagy-dependent induction of tolerogenic dendritic cells

Biomaterials ◽  
2017 ◽  
Vol 146 ◽  
pp. 13-28 ◽  
Author(s):  
Sergej Tomić ◽  
Kristina Janjetović ◽  
Dušan Mihajlović ◽  
Marina Milenković ◽  
Tamara Kravić-Stevović ◽  
...  
Keyword(s):  
Quantum Dots ◽  
Dendritic Cells ◽  
T Cell ◽  
Graphene Quantum Dots ◽  
T Cell Responses ◽  
Cell Responses ◽  
Tolerogenic Dendritic Cells

scholarly journals Tolerogenic Dendritic Cells Derived from Donors with Natural Rubber Latex Allergy Modulate Allergen-Specific T-Cell Responses and IgE Production

PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e85930 ◽  
Author(s):  
Alejandro Escobar ◽  
Adam Aguirre ◽  
María Antonieta Guzmán ◽  
Rodrigo González ◽  
Diego Catalán ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
Natural Rubber ◽  
Natural Rubber Latex ◽  
T Cell Responses ◽  
Latex Allergy ◽  
Rubber Latex ◽  
Cell Responses ◽  
Tolerogenic Dendritic Cells

scholarly journals The role of dendritic cells for therapy of B-cell lymphoma with immune checkpoint inhibitors

2020 ◽  
Author(s):  
Anne Scheuerpflug ◽  
Fatima Ahmetlić ◽  
Vera Bauer ◽  
Tanja Riedel ◽  
Martin Röcken ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
T Cell ◽  
B Cell ◽  
Immune Checkpoint ◽  
Cell Lymphoma ◽  
T Cell Responses ◽  
B Cell Lymphoma ◽  
Cell Responses

Abstract Immune checkpoint blocking (ICB) is a promising new tool of cancer treatment. Yet, the underlying therapeutic mechanisms are not fully understood. Here we investigated the role of dendritic cells (DCs) for the therapeutic effect of ICB in a λ-MYC-transgenic mouse model of endogenously arising B-cell lymphoma. The growth of these tumors can be effectively delayed by antibodies against CTLA-4 and PD-1. Tumor-infiltrating DCs from mice having received therapy showed an upregulation of costimulatory molecules as well as an augmented IL-12/IL-10 ratio as compared to untreated controls. Both alterations seemed to be induced by interferon-γ (IFN-γ), which is upregulated in T cells and natural killer cells upon ICB. Furthermore, the enhanced IL-12/IL-10 ratio, which favors Th1-prone antitumor T-cell responses, was a consequence of direct interaction of ICB antibodies with DCs. Importantly, the capability of tumor-infiltrating DCs of stimulating peptide-specific or allogeneic T-cell responses in vitro was improved when DCs were derived from ICB-treated mice. The data indicate that ICB therapy is not only effective by directly activating T cells, but also by triggering a complex network, in which DCs play a pivotal role at the interface between innate and adaptive antitumor responses.

scholarly journals Heligmosomoides polygyrus bakeri Induces Tolerogenic Dendritic Cells that Block Colitis and Prevent Antigen-Specific Gut T Cell Responses

2012 ◽  
Vol 189 (5) ◽  
pp. 2512-2520 ◽  
Author(s):  
Arthur M. Blum ◽  
Long Hang ◽  
Tommy Setiawan ◽  
Joseph P. Urban ◽  
Korynn M. Stoyanoff ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Heligmosomoides Polygyrus ◽  
Cell Responses ◽  
Tolerogenic Dendritic Cells

Current Understanding of the Role of Dendritic Cells and Their Co-Stimulatory Molecules in Generating Efficient T Cell Responses in Lepromatous Leprosy

2007 ◽  
Vol 3 (1) ◽  
pp. 77-85 ◽  
Author(s):  
Dilvani Santos ◽  
Alice Miranda ◽  
Philip Suffys ◽  
Carlos Rodrigues ◽  
Saulo Bourguignon ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
T Cell ◽  
T Cell Responses ◽  
Lepromatous Leprosy ◽  
Current Understanding ◽  
Cell Responses

scholarly journals The role of cDC1s in vivo: CD8 T cell priming through cross-presentation

F1000Research ◽  
2017 ◽  
Vol 6 ◽  
pp. 98 ◽  
Author(s):  
Derek Theisen ◽  
Kenneth Murphy
Keyword(s):  
Bone Marrow ◽  
Dendritic Cells ◽  
T Cell ◽  
Antigen Processing ◽  
Molecular Mechanisms ◽  
T Cell Responses ◽  
Cd8 T Cell ◽  
Cross Presentation ◽  
Cell Responses

The cDC1 subset of classical dendritic cells is specialized for priming CD8 T cell responses through the process of cross-presentation. The molecular mechanisms of cross-presentation remain incompletely understood because of limited biochemical analysis of rare cDC1 cells, difficulty in their genetic manipulation, and reliance onin vitrosystems based on monocyte- and bone-marrow-derived dendritic cells. This review will discuss cross-presentation from the perspective of studies with monocyte- or bone-marrow-derived dendritic cells while highlighting the need for future work examining cDC1 cells. We then discuss the role of cDC1s as a cellular platform to combine antigen processing for class I and class II MHC presentation to allow the integration of “help” from CD4 T cells during priming of CD8 T cell responses.

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