scholarly journals Type I Interferon (IFNα) Acts Directly on Human Memory CD4+T Cells Altering Their Response to Antigen

2009 ◽  
Vol 183 (5) ◽  
pp. 2915-2920 ◽  
Author(s):  
Kathleen M. E. Gallagher ◽  
Sarah Lauder ◽  
Ian W. Rees ◽  
Awen M. Gallimore ◽  
Andrew J. Godkin
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Type I Interferon ◽  
Human Memory ◽  
Type I ◽  
Memory Cd4 T Cells

scholarly journals c-Jun Controls the Ability of IL-12 to Induce IL-10 Production from Human Memory CD4+ T Cells

2009 ◽  
Vol 183 (7) ◽  
pp. 4475-4482 ◽  
Author(s):  
Carlos A. Garcia ◽  
Huizhi Wang ◽  
Manjunatha R. Benakanakere ◽  
Elyse Barrett ◽  
Denis F. Kinane ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Human Memory ◽  
Memory Cd4 T Cells

The Role of IL-12 and IL-23 in the Generation and Maintenance of Memory CD4+ T Cells.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 2664-2664
Author(s):  
Aileen M. Cleary ◽  
David B. Lewis
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Chemokine Receptors ◽  
Human Memory ◽  
Surface Expression ◽  
Effector Memory ◽  
Memory Cells ◽  
Peripheral Lymph ◽  
And Function ◽  
Memory Cd4 T Cells

Abstract Human memory CD4+ T cells can be distinguished from antigenically-naïve CD4+ T cells based on their CD45RAlowCD45R0high and CD45RAhighCD45R0low surface phenotypes, respectively. Memory CD4+ T cells from adult peripheral blood can be further divided based on surface expression of the CCR7 chemokine receptor. Th1 memory CD4+ T cells that are CCR7high (putative central memory cells or Tcm) are expected to be preferentially targeted to peripheral lymph nodes where the ligands for CCR7 are expressed in high amounts. These cells have been reported to lack expression of the CCR3 and CCR5 chemokine receptors, which facilitate entry into inflamed tissues, and produce little or no interferon (IFN)-γ after stimulation via the αβ-TCR/CD3 complex. CD45RAlowCD45R0highCCR7low CD4+ T cells account for virtually all IFN-g production by human CD4 T cells after ab-TCR/CD3 stimulation using monoclonal antibodies, and for this reason were termed effector memory cells (Tem). These findings, as well as the observation of shorter telomere lengths for memory CD4+ T cells that are CCR7low compared to those that CCR7high suggest that the Tcm population may be an intermediate between naïve CD4+ T cells and Tem. It has recently been proposed that the level of signal strength and γc containing cytokines play a role in memory T cell generation. However, little is known whether IL-12 or IL-23 are necessary and for this differentiation and/or maintenance. Our laboratory has previously described a patient with IL-12Rβ1 deficiency, which ablates both IL-12 and IL-23 signaling. This patient had a deficiency in Tem number and function, unexpectedly suggesting that IL-12 and/or IL-23 may play a key role in this process. We therefore hypothesized that signaling through IL-12Rβ1 plays a key role in the latter stages of generation and/or maintenance of human memory CD4+ T cells. Preliminary data thus far show CCR7 expression to be slightly decreased on activated Tcm in response to incubation with IL-2 or IL-12 alone, and to a greater extent with IL-2 and IL-12 incubated together. In addition, spontaneous apoptosis of both Tcm and Tem is decreased upon incubation with IL-12. Taken together, these data suggest that IL-12 may play a role in both generation of Tem and maintenance of both Tcm and Tem.

scholarly journals Granzyme B- and Fas ligand-mediated cytotoxic function induced by mitogenic CD28 stimulation of human memory CD4+T cells

2012 ◽  
Vol 91 (5) ◽  
pp. 759-771 ◽  
Author(s):  
Miguel A. Medina ◽  
Jacob Couturier ◽  
Marsha L. Feske ◽  
Ashley E. Mahne ◽  
Mary Turner ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Fas Ligand ◽  
Granzyme B ◽  
Human Memory ◽  
Memory Cd4 T Cells ◽  
Cytotoxic Function ◽  
Stimulation Of

scholarly journals Functional Killer Ig-Like Receptors on Human Memory CD4+ T Cells Specific for Cytomegalovirus

2009 ◽  
Vol 182 (7) ◽  
pp. 4175-4182 ◽  
Author(s):  
Jeroen van Bergen ◽  
Engelina M. C. Kooy-Winkelaar ◽  
Henrike van Dongen ◽  
Floris A. van Gaalen ◽  
Allan Thompson ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Human Memory ◽  
Memory Cd4 T Cells

scholarly journals Stem-Like Characteristics in a Subset of CD161 Expressing Human Memory CD4+ T Cells Facilitates Their Survival After Chemotherapy

2013 ◽  
Vol 19 (2) ◽  
pp. S134
Author(s):  
Abdullah Alsuliman ◽  
Ahmad Khoder ◽  
Kate Stringaris ◽  
Takuya Sekine ◽  
Bonnie Razzaghi ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Human Memory ◽  
Memory Cd4 T Cells

scholarly journals Type I interferon potentiates T-cell receptor mediated induction of IL-10-producing CD4+T cells

2013 ◽  
Vol 43 (10) ◽  
pp. 2730-2740 ◽  
Author(s):  
Béatrice Corre ◽  
Julie Perrier ◽  
Margueritte El Khouri ◽  
Silvia Cerboni ◽  
Sandra Pellegrini ◽  
...  
Keyword(s):  
T Cells ◽  
T Cell ◽  
T Cell Receptor ◽  
Cd4 T Cells ◽  
Type I Interferon ◽  
Cell Receptor ◽  
Type I

scholarly journals A Dichotomy in Cortical Actin and Chemotactic Actin Activity between Human Memory and Naive T Cells Contributes to Their Differential Susceptibility to HIV-1 Infection

2012 ◽  
Vol 287 (42) ◽  
pp. 35455-35469 ◽  
Author(s):  
Weifeng Wang ◽  
Jia Guo ◽  
Dongyang Yu ◽  
Paul J. Vorster ◽  
WanJun Chen ◽  
...  
Keyword(s):  
T Cells ◽  
Cd4 T Cells ◽  
Differential Susceptibility ◽  
Human Memory ◽  
Actin Dynamics ◽  
Cortical Actin ◽  
Naive T Cells ◽  
Naïve T Cells ◽  
Memory Cd4 T Cells ◽  
Hiv 1

Human memory and naive CD4 T cells can mainly be identified by the reciprocal expression of the CD45RO or CD45RA isoforms. In HIV-1 infection, blood CD45RO memory CD4 T cells are preferentially infected and serve as a major viral reservoir. The molecular mechanism dictating this differential susceptibility to HIV-1 remains largely obscure. Here, we report that the different susceptibility of memory and naive T cells to HIV is not determined by restriction factors such as Apobec3G or BST2. However, we observed a phenotypic distinction between human CD45RO and CD45RA resting CD4 T cells in their cortical actin density and actin dynamics. CD45RO CD4 T cells possess a higher cortical actin density and can be distinguished as CD45RO+Actinhigh. In contrast, CD45RA T cells are phenotypically CD45RA+Actinlow. In addition, the cortical actin in CD45RO memory CD4 T cells is more dynamic and can respond to low dosages of chemotactic induction by SDF-1, whereas that of naive cells cannot, despite a similar level of the chemokine receptor CXCR4 present on both cells. We further demonstrate that this difference in the cortical actin contributes to their differential susceptibility to HIV-1; resting memory but not naive T cells are highly responsive to HIV-mediated actin dynamics that promote higher levels of viral entry and early DNA synthesis in resting memory CD4 T cells. Furthermore, transient induction of actin dynamics in resting naive T cells rescues HIV latent infection following CD3/CD28 stimulation. These results suggest a key role of chemotactic actin activity in facilitating HIV-1 latent infection of these T cell subsets.

scholarly journals Granzyme B secretion by human memory CD4 T cells is less strictly regulated compared to memory CD8 T cells

2014 ◽  
Vol 15 (1) ◽  
Author(s):  
Lin Lin ◽  
Jacob Couturier ◽  
Xiaoying Yu ◽  
Miguel A Medina ◽  
Claudia A Kozinetz ◽  
...  
Keyword(s):  
T Cells ◽  
Cd8 T Cells ◽  
Cd4 T Cells ◽  
Granzyme B ◽  
Human Memory ◽  
Memory Cd8 T Cells ◽  
Memory Cd4 T Cells
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