scholarly journals The Role of Hepatic Invariant NKT Cells in Systemic/Local Inflammation and Mortality during Polymicrobial Septic Shock

2009 ◽  
Vol 182 (4) ◽  
pp. 2467-2475 ◽  
Author(s):  
Caroline K. Hu ◽  
Fabienne Venet ◽  
David S. Heffernan ◽  
Yvonne L. Wang ◽  
Brian Horner ◽  
...  
Keyword(s):  
Septic Shock ◽  
Nkt Cells ◽  
Local Inflammation ◽  
Invariant Nkt Cells

The Role of Invariant NKT Cells in Immunity

2016 ◽  
pp. 357-368
Author(s):  
Antonia Rotolo ◽  
Aristeidis Chaidos ◽  
Anastasios Karadimitris
Keyword(s):  
Nkt Cells ◽  
Invariant Nkt Cells

Investigation of the role of CD1d-restricted invariant NKT cells in experimental choroidal neovascularization

2008 ◽  
Vol 374 (1) ◽  
pp. 38-43 ◽  
Author(s):  
Kuniaki Hijioka ◽  
Koh-Hei Sonoda ◽  
Chikako Tsutsumi-Miyahara ◽  
Takeshi Fujimoto ◽  
Yuji Oshima ◽  
...  
Keyword(s):  
Choroidal Neovascularization ◽  
Nkt Cells ◽  
Invariant Nkt Cells

Invariant NKT Cells Regulate Osteoclast Development and Function Under Homeostatic and during Conditions of Immune Activation

Blood ◽  
2008 ◽  
Vol 112 (11) ◽  
pp. 104-104
Author(s):  
Ming Hu ◽  
J.H. Duncan Basssett ◽  
Lynette Danks ◽  
Emmanouil Spanoudakis ◽  
Ke Xu ◽  
...  
Keyword(s):  
Immune Responses ◽  
Nkt Cells ◽  
Innate Immune ◽  
Small Subset ◽  
Developmental Defect ◽  
Invariant Nkt Cells ◽  
And Function ◽  
Actin Rings

Abstract Invariant NKT cells, a small subset of immunoregulatory T cells restricted by the glycolipid-presenting non-polymorphic CD1d molecule, are able to modulate a variety of innate and adaptive immune responses. Osteoclasts (OC) are bone resorbing polykaryons of hematopoietic lineage, that have the capacity to regulate myeloid cell egress from bone marrow (BM) thus making them an integral part of the innate immune response. We and others previously showed that NKT cells regulate hematopoiesis in mice as well as humans. In this work, we investigate the role of NKT cells in OC development and function in homeostasis and after their specific activation by the model glycolipid alpha-galactosylceramide (aGC). Using quantitative back scattered electron scanning microscopy, we found that TCR Ja18 −/− mice which selectively lack development of NKT cells, exhibit a moderate osteopetrotic phenotype affecting trabecular as well as cortical bone. Histologically, these mice had the same number of TRAP+ OC as WT mice suggesting a maturation rather developmental defect in the TCR Ja18 −/−-derived OC. In vitro differentiation in the presence of RANKL and M-CSF showed that while TCR Ja18 −/− BM cells are capable of forming multinucleated OC, these, as assessed by confocal microscopy, fail to form F-actin rings and sealing zone and thus are unable to resorb bone. Further underscoring the effect of NKT cells in this process, CD45.1+ BM cells highly purified from CD45.2+ WT/CD45.1+ TCRJa18 −/− mixed BM chimeras displayed restoration of their OC F-actin rings. Next we investigated whether in vivo activated NKT cells regulate OC function. We found that a single injection of aGC dramatically increased the number of CD3-B220-CD11b-c-fmshighc- kithigh BM OC progenitors and accelerated the in vitro development of OC in WT but not TCR Ja18 −/− mice. Furthermore, this resulted in high serum levels of IFN-g and IL-4 but not IL-1 or IL-17. An aGC-mediated increase of OC progenitors was observed in IFN-g −/− but not IL-4 −/−mice suggesting that NKT cell-derived IL-4 is the main cytokine promoting osteoclastogenesis in this context. Taken together, our data demonstrate a novel role of NKT cells in homeostatic bone mass regulation and in the orchestration of innate immune responses through regulation of OC development and function.

ORIGINAL ARTICLE: The Role of Invariant NKT Cells in Pre-Eclampsia

2008 ◽  
Vol 60 (2) ◽  
pp. 118-126 ◽  
Author(s):  
Eva Miko ◽  
Laszlo Szereday ◽  
Aliz Barakonyi ◽  
Andrea Jarkovich ◽  
Peter Varga ◽  
...  
Keyword(s):  
Nkt Cells ◽  
Invariant Nkt Cells

Role of invariant NKT cells in lipopolysaccharide-induced lethal shock during encephalomyocarditis virus infection

Immunobiology ◽  
2017 ◽  
Vol 222 (2) ◽  
pp. 350-357
Author(s):  
Tatsuya Ando ◽  
Hiroyasu Ito ◽  
Hirofumi Ohtaki ◽  
Ayumu Kanbe ◽  
Akihiro Hirata ◽  
...  
Keyword(s):  
Virus Infection ◽  
Nkt Cells ◽  
Encephalomyocarditis Virus ◽  
Invariant Nkt Cells ◽  
Lethal Shock

scholarly journals NKT Cells in Sepsis

2010 ◽  
Vol 2010 ◽  
pp. 1-10 ◽  
Author(s):  
Briana Leung ◽  
Hobart W. Harris
Keyword(s):  
Septic Shock ◽  
T Cells ◽  
Immune Cells ◽  
Natural Killer T Cells ◽  
Nkt Cells ◽  
Innate And Adaptive Immunity ◽  
Gram Negative ◽  
Sepsis And Septic Shock ◽  
Killer T Cells

Sepsis is currently a leading cause of death in hospital intensive care units. Previous studies suggest that the pathophysiology of sepsis involves the hyperactivation of complex proinflammatory cascades that include the activation of various immune cells and the exuberant secretion of proinflammatory cytokines by these cells. Natural killer T-cells (NKTs) are a sublineage of T cells that share characteristics of conventional T cells and NK cells and bridge innate and adaptive immunity. More recently, NKT cells have been implicated in microbial immunity, including the onset of sepsis. Moreover, apolipoprotein E (apoE), a component of triglyceride-rich lipoproteins, has been shown to be protective in endotoxemia and gram-negative infections in addition to its well-known role in lipid metabolism. Here, we will review the role of NKT cells in sepsis and septic shock, the immunoregulatory role of apoE in the host immune response to infection, and propose a mechanism for this immunoregulation.

scholarly journals The Regulatory Role of Invariant NKT Cells in Tumor Immunity

2015 ◽  
Vol 3 (5) ◽  
pp. 425-435 ◽  
Author(s):  
Rosanna M. McEwen-Smith ◽  
Mariolina Salio ◽  
Vincenzo Cerundolo
Keyword(s):  
Tumor Immunity ◽  
Nkt Cells ◽  
Regulatory Role ◽  
Invariant Nkt Cells
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