scholarly journals Chemokine Receptor CXCR5 Supports Solitary Intestinal Lymphoid Tissue Formation, B Cell Homing, and Induction of Intestinal IgA Responses

2009 ◽  
Vol 182 (5) ◽  
pp. 2610-2619 ◽  
Author(s):  
Sarvari Velaga ◽  
Heike Herbrand ◽  
Michaela Friedrichsen ◽  
Tian Jiong ◽  
Martina Dorsch ◽  
...  
Keyword(s):  
B Cell ◽  
Chemokine Receptor ◽  
Lymphoid Tissue ◽  
Tissue Formation ◽  
Cell Homing ◽  
Intestinal Lymphoid Tissue ◽  
Intestinal Iga

scholarly journals Abnormal Expression of the B-Cell Homing Chemokine Receptor BLR1 During the Progression of Acquired Immunodeficiency Syndrome

Blood ◽  
1997 ◽  
Vol 90 (2) ◽  
pp. 520-525 ◽  
Author(s):  
Reinhold Förster ◽  
Georgina Schweigard ◽  
Sabine Johann ◽  
Thomas Emrich ◽  
Elisabeth Kremmer ◽  
...  
Keyword(s):  
B Cell ◽  
Chemokine Receptor ◽  
Acquired Immunodeficiency Syndrome ◽  
Peripheral Blood ◽  
Lymphoid Tissue ◽  
Healthy Individuals ◽  
T Helper ◽  
Cell Homing ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

Abstract The putative chemokine receptor BLR1 has been identified as the first G-protein–coupled receptor involved in B-cell migration and in microenvironmental homing to B-cell follicles and to germinal centers. In healthy individuals, expression of BLR1 is restricted to all mature recirculating B cells and to a subpopulation of T-helper memory cells. In the present study, we analyzed the distribution of BLR1 on defined lymphocyte subsets during the progression of acquired immunodeficiency syndrome. It is shown that the proportion of T-helper memory cells coexpressing BLR1 continuously decreases during the infection, whereas a high proportion of γ/δ T cells expressing BLR1 can be found in peripheral blood. The latter subpopulation is restricted to lymphoid tissues in healthy individuals. Most interestingly, in 75% of all human immunodeficiency virus (HIV)+ individuals, peripheral blood B cells were identified as not expressing BLR1 and phenotypically resembling germinal center cells of lymphoid tissue. Using BLR1 as a marker molecule, this study identifies peripheral blood lymphocytes in HIV+ individuals that are usually restricted to lymphoid tissue in healthy individuals. Because HIV infection is active in lymphoid tissue even at the clinically latent stage, aberrant expression of the B-cell homing chemokine receptor BLR1 might be an early indicator for the onset of destruction of lymphoid tissue.

scholarly journals Abnormal Expression of the B-Cell Homing Chemokine Receptor BLR1 During the Progression of Acquired Immunodeficiency Syndrome

Blood ◽  
1997 ◽  
Vol 90 (2) ◽  
pp. 520-525
Author(s):  
Reinhold Förster ◽  
Georgina Schweigard ◽  
Sabine Johann ◽  
Thomas Emrich ◽  
Elisabeth Kremmer ◽  
...  
Keyword(s):  
B Cell ◽  
Chemokine Receptor ◽  
Acquired Immunodeficiency Syndrome ◽  
Peripheral Blood ◽  
Lymphoid Tissue ◽  
Healthy Individuals ◽  
T Helper ◽  
Cell Homing ◽  
Acquired Immunodeficiency ◽  
Immunodeficiency Syndrome

The putative chemokine receptor BLR1 has been identified as the first G-protein–coupled receptor involved in B-cell migration and in microenvironmental homing to B-cell follicles and to germinal centers. In healthy individuals, expression of BLR1 is restricted to all mature recirculating B cells and to a subpopulation of T-helper memory cells. In the present study, we analyzed the distribution of BLR1 on defined lymphocyte subsets during the progression of acquired immunodeficiency syndrome. It is shown that the proportion of T-helper memory cells coexpressing BLR1 continuously decreases during the infection, whereas a high proportion of γ/δ T cells expressing BLR1 can be found in peripheral blood. The latter subpopulation is restricted to lymphoid tissues in healthy individuals. Most interestingly, in 75% of all human immunodeficiency virus (HIV)+ individuals, peripheral blood B cells were identified as not expressing BLR1 and phenotypically resembling germinal center cells of lymphoid tissue. Using BLR1 as a marker molecule, this study identifies peripheral blood lymphocytes in HIV+ individuals that are usually restricted to lymphoid tissue in healthy individuals. Because HIV infection is active in lymphoid tissue even at the clinically latent stage, aberrant expression of the B-cell homing chemokine receptor BLR1 might be an early indicator for the onset of destruction of lymphoid tissue.

scholarly journals Chemokine Requirements for B Cell Entry to Lymph Nodes and Peyer's Patches

2002 ◽  
Vol 196 (1) ◽  
pp. 65-75 ◽  
Author(s):  
Takaharu Okada ◽  
Vu N. Ngo ◽  
Eric H. Ekland ◽  
Reinhold Förster ◽  
Martin Lipp ◽  
...  
Keyword(s):  
Lymph Nodes ◽  
B Cell ◽  
Chemokine Receptor ◽  
Cell Entry ◽  
Peyer's Patches ◽  
Peyer’S Patches ◽  
Wild Type ◽  
High Endothelial Venules ◽  
Cell Homing ◽  
T Cell Homing

B cell entry to lymph nodes and Peyer's patches depends on chemokine receptor signaling, but the principal chemokine involved has not been defined. Here we show that the homing of CXCR4−/− B cells is suppressed in CCL19 (ELC)- and CCL21 (SLC)-deficient paucity of lymph node T cells mice, but not in wild-type mice. We also find that CXCR4 can contribute to T cell homing. Using intravital microscopy, we find that B cell adhesion to high endothelial venules (HEVs) is disrupted when CCR7 and CXCR4 are predesensitized. In Peyer's patches, B cell entry is dependent on CXCR5 in addition to CCR7/CXCR4. CXCL12 (SDF1) is displayed broadly on HEVs, whereas CXCL13 (BLC) is found selectively on Peyer's patch follicular HEVs. These findings establish the principal chemokine and chemokine receptor requirements for B cell entry to lymph nodes and Peyer's patches.

scholarly journals Adaptation of Solitary Intestinal Lymphoid Tissue in Response to Microbiota and Chemokine Receptor CCR7 Signaling

2006 ◽  
Vol 177 (10) ◽  
pp. 6824-6832 ◽  
Author(s):  
Oliver Pabst ◽  
Heike Herbrand ◽  
Michaela Friedrichsen ◽  
Sarvari Velaga ◽  
Martina Dorsch ◽  
...  
Keyword(s):  
Chemokine Receptor ◽  
Lymphoid Tissue ◽  
Intestinal Lymphoid Tissue

scholarly journals Nuclear Export of the NF-κB Inhibitor IκBα Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation

Immunity ◽  
2011 ◽  
Vol 34 (3) ◽  
pp. 449 ◽  
Author(s):  
Shelly M. Wuerzberger-Davis ◽  
Yuhong Chen ◽  
David T. Yang ◽  
Jeffrey D. Kearns ◽  
Paul W. Bates ◽  
...  
Keyword(s):  
B Cell ◽  
Nuclear Export ◽  
Lymphoid Tissue ◽  
Tissue Formation ◽  
Secondary Lymphoid Tissue

scholarly journals Influence of subalin probiotic on Blue Frost fox intestinal lymphoid tissue formation

2021 ◽  
Vol 282 ◽  
pp. 04007
Author(s):  
A.S. Syutkina ◽  
I.A Domskiy ◽  
I.I. Okulova
Keyword(s):  
Experimental Animal ◽  
Lymphoid Tissue ◽  
Tissue Formation ◽  
Analog Method ◽  
Animal Group ◽  
Basic Diet ◽  
Intestinal Lymphoid Tissue

For research, Blue Frost fox puppies were used at the age of 2 months. 2 groups of animals of 30 heads in each group were formed by the analog method. The experimental animal group received subalin courses with the basic diet according to the scheme: 5 days of probiotic in the amount of 10 - 20 * 107 CFU/kg, for two months in courses with 10 days break, only 4 courses.

scholarly journals Nuclear Export of the NF-κB Inhibitor IκBα Is Required for Proper B Cell and Secondary Lymphoid Tissue Formation

Immunity ◽  
2011 ◽  
Vol 34 (2) ◽  
pp. 188-200 ◽  
Author(s):  
Shelly M. Wuerzberger-Davis ◽  
Yuhong Chen ◽  
David T. Yang ◽  
Jeffrey D. Kearns ◽  
Paul W. Bates ◽  
...  
Keyword(s):  
B Cell ◽  
Nuclear Export ◽  
Lymphoid Tissue ◽  
Tissue Formation ◽  
Secondary Lymphoid Tissue

scholarly journals Follicular B Helper T Cells Express Cxc Chemokine Receptor 5, Localize to B Cell Follicles, and Support Immunoglobulin Production

2000 ◽  
Vol 192 (11) ◽  
pp. 1545-1552 ◽  
Author(s):  
Dagmar Breitfeld ◽  
Lars Ohl ◽  
Elisabeth Kremmer ◽  
Joachim Ellwart ◽  
Federica Sallusto ◽  
...  
Keyword(s):  
T Cells ◽  
B Cell ◽  
Chemokine Receptor ◽  
Costimulatory Molecule ◽  
Lymphoid Organs ◽  
Helper T Cells ◽  
Cell Homing ◽  
Cxc Chemokine ◽  
Secondary Lymphoid Organs ◽  
Chemokine Receptor 5

Chemokines and their receptors have been identified as major regulators controlling the functional organization of secondary lymphoid organs. Here we show that expression of CXC chemokine receptor 5 (CXCR5), a chemokine receptor required for B cell homing to B cell follicles, defines a novel subpopulation of B helper T cells localizing to follicles. In peripheral blood these cells coexpress CD45RO and the T cell homing CC chemokine receptor 7 (CCR7). In secondary lymphoid organs, CD4+CXCR5+ cells lose expression of CCR7, which allows them to localize to B cell follicles and germinal centers where they express high levels of CD40 ligand (CD40L), a costimulatory molecule required for B cell activation and inducible costimulator (ICOS), a recently identified costimulatory molecule of the CD28 family. Thus, when compared with CD4+CD45RO+CXCR5− cells, CD4+CD45RO+CXCR5+ tonsillar T cells efficiently support the production of immunoglobulin (Ig)A and IgG. In contrast, analysis of the memory response revealed that long-lasting memory cells are found within the CD4+CD45RO+CXCR5− population, suggesting that CXCR5+CD4 cells represent recently activated effector cells. Based on the characteristic localization within secondary lymphoid organs, we suggest to term these cells “follicular B helper T cells” (TFH).

Unaltered levels of transplant arteriosclerosis in the absence of the B cell homing chemokine receptor CXCR5

2009 ◽  
Vol 20 (4) ◽  
pp. 218-223 ◽  
Author(s):  
Stephan M. Ensminger ◽  
Silke Abele-Ohl ◽  
Lars Ohl ◽  
Bernd M. Spriewald ◽  
Martina Ramsperger-Gleixner ◽  
...  
Keyword(s):  
B Cell ◽  
Chemokine Receptor ◽  
Cell Homing ◽  
Transplant Arteriosclerosis
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