scholarly journals Gene Expression Profiles of Primary Breast Cancer Tissue Using cDNA Microarray

2002 ◽  
Vol 5 (4) ◽  
pp. 284 ◽  
Author(s):  
Wonshik Han ◽  
Ki Wook Chung ◽  
Soo Jung Ahn ◽  
Dong Young Noh ◽  
Yeo Kyu Youn ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cdna Microarray ◽  
Primary Breast Cancer ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Breast Cancer Tissue ◽  
Cancer Tissue ◽  
Primary Breast Cancer Tissue

scholarly journals ”BIK/NBK Gene Expression as a Possible Marker of Circulating Breast Cancer Cells in Blood“

2011 ◽  
Vol 4 (1) ◽  
pp. 8-14
Author(s):  
E. Lopez-Munoz ◽  
N. Garcia-Hernandez ◽  
R. I. Penaloza-Espinosa ◽  
M. E. Gomez-Del Toro ◽  
G. Zarco-Espinosa ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Therapeutic Target ◽  
Breast Cancer Cells ◽  
Expression Profiles ◽  
Gene Expression Profiles ◽  
Breast Cancer Tissue ◽  
Cancer Tissue ◽  
Mrna Gene

The detection of circulating breast cancer cells in blood could be of special interest as an indicator of diagnosis and prognosis, and for the selection of treatment. In a previous report, our research group determined gene expression profiles in samples of breast cancer tissue, identifying over-expression of the BIK/NBK mRNA gene in 90% of the analyzed samples. In this paper, we analyze the BIK/NBK gene expression as a possible biomarker of circulating breast cancer cells in blood. We demonstrate that the BIK/NBK gene expression is not a significant biomarker in the detection of circulating breast cancer cells in the blood of women with breast cancer. Several studies have evaluated the regulation of apoptosis by estrogens in breast cancer cells, demonstrating the importance of BIK/NBK protein, in estrogen-regulated breast cancer cell apoptosis, which suggests that the regulation of its expression may be an important therapeutic target or strategy in the management of cancer, and, although we did not find statistically significant differences among the patient groups to demonstrate that BIK/NBK gene expression is a biomarker of circulating breast cancer cells in blood, we consider it necessary to continue the study of this gene in breast cancer tissue and its role in the development and progression of breast cancer, its prognostic value, and its potential use as therapeutic target.

Gene Expression Profiles and Prognostic Markers for Primary Breast Cancer

2007 ◽  
pp. 131-138
Author(s):  
Yixin Wang ◽  
Jan Klijn ◽  
Yi Zhang ◽  
David Atkins ◽  
John Foekens
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Primary Breast Cancer ◽  
Prognostic Markers ◽  
Expression Profiles ◽  
Gene Expression Profiles

Determining tamoxifen sensitivity using primary breast cancer tissue in collagen-based three-dimensional culture

Biomaterials ◽  
2012 ◽  
Vol 33 (3) ◽  
pp. 907-915 ◽  
Author(s):  
Alexander D. Leeper ◽  
Joanne Farrell ◽  
Linda J. Williams ◽  
Jeremy S. Thomas ◽  
J. Michael Dixon ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Primary Breast Cancer ◽  
Three Dimensional ◽  
Breast Cancer Tissue ◽  
Cancer Tissue ◽  
Three Dimensional Culture ◽  
Primary Breast Cancer Tissue ◽  
Tamoxifen Sensitivity
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