scholarly journals Efficiency of Ultrasound and Ultrasound-Guided Fine Needle Aspiration Cytology in Preoperative Assessment of Axillary Lymph Node Metastases in Breast Cancer

2012 ◽  
Vol 15 (2) ◽  
pp. 211 ◽  
Author(s):  
Aysegul Oz ◽  
Figen Basaran Demirkazik ◽  
Meltem Gulsun Akpinar ◽  
Isıl Soygur ◽  
Atac Baykal ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Preoperative Assessment ◽  
Needle Aspiration ◽  
Axillary Lymph ◽  
Ultrasound Guided ◽  
Aspiration Cytology ◽  
Axillary Lymph Node Metastases ◽  
Fine Needle ◽  
Node Metastases ◽  
Needle Aspiration Cytology

scholarly journals Ultrasound Guided Core Biopsy versus Fine Needle Aspiration for Evaluation of Axillary Lymphadenopathy in Patients with Breast Cancer

ISRN Oncology ◽  
2014 ◽  
Vol 2014 ◽  
pp. 1-9 ◽  
Author(s):  
Marie A. Ganott ◽  
Margarita L. Zuley ◽  
Gordon S. Abrams ◽  
Amy H. Lu ◽  
Amy E. Kelly ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Fine Needle Aspiration ◽  
Core Biopsy ◽  
Needle Aspiration ◽  
Axillary Node ◽  
Axillary Lymph ◽  
Ultrasound Guided ◽  
Axillary Lymph Node Metastases ◽  
Fine Needle ◽  
Node Metastases

Rationale and Objectives. To compare the sensitivities of ultrasound guided core biopsy and fine needle aspiration (FNA) for detection of axillary lymph node metastases in patients with a current diagnosis of ipsilateral breast cancer. Materials and Methods. From December 2008 to December 2010, 105 patients with breast cancer and abnormal appearing lymph nodes in the ipsilateral axilla consented to undergo FNA of an axillary node immediately followed by core biopsy of the same node, both with ultrasound guidance. Experienced pathologists evaluated the aspirate cytology without knowledge of the core histology. Cytology and core biopsy results were compared to sentinel node excision or axillary dissection pathology. Sensitivities were compared using McNemar’s test. Results. Of 70 patients with axillary node metastases, FNA was positive in 55/70 (78.6%) and core was positive in 61/70 (87.1%) (P = 0.18). The FNA and core results were discordant in 14/70 (20%) patients. Ten cases were FNA negative/core positive. Four cases were FNA positive/core negative. Conclusion. Core biopsy detected six (8.6%) more cases of metastatic lymphadenopathy than FNA but the difference in sensitivities was not statistically significant. Core biopsy should be considered if the node is clearly imaged and readily accessible. FNA is a good alternative when a smaller needle is desired due to node location or other patient factors. This trial is registered with NCT01920139.

scholarly journals Comparative study between ultrasound-guided fine needle aspiration cytology of axillary lymph nodes and sentinel lymph node histopathology in early-stage breast cancer

2017 ◽  
Vol 13 (5) ◽  
pp. 3299-3302 ◽  
Author(s):  
Lívio Portela Cardoso-Coelho ◽  
Rafael Soares Borges ◽  
Airlane Pereira Alencar ◽  
Larysse Maira Cardoso-Campos-Verdes ◽  
João Paulo da Silva-Sampaio ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Early Stage ◽  
Needle Aspiration ◽  
Axillary Lymph Nodes ◽  
Axillary Lymph ◽  
Ultrasound Guided ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

scholarly journals Role of Percutaneous Needle Biopsy of Axillary Lymph Nodes to Evaluate Node Positive Breast Cancer after Neoadjuvant Chemotherapy

2019 ◽  
Vol 73 (4) ◽  
pp. 368-372
Author(s):  
Baiba Līcīte ◽  
Arvīds Irmejs ◽  
Jeļena Maksimenko ◽  
Pēteris Loža ◽  
Genādijs Trofimovičs ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Needle Aspiration ◽  
Axillary Node ◽  
Axillary Lymph ◽  
Ultrasound Guided ◽  
Aspiration Cytology ◽  
Node Positive ◽  
Needle Aspiration Cytology ◽  
Positive Breast Cancer

Abstract The aim of the study was to evaluate the role of ultrasound guided fine needle aspiration cytology (FNAC) in the restaging of node positive breast cancer after neoadjuvant chemotherapy (NAC). From January 2016 – October 2018, 90 node positive stage IIA-IIIC breast cancer cases undergoing NAC were included in the study. The largest, most superficial and the most caudal axillary node metastasis confirmed by fine needle aspiration cytology (FNAC) was marked with clip. After NAC, restaging of axilla was performed with ultrasound and FNAC of the marked and/or the most suspicious axillary node. Of the 90 cases, 58 with available ultrasound guided percutaneous needle biopsy data were further evaluated. Axilla conserving surgery was performed in 37 of 58 cases and axillary lymph node dissection (ALND) in 21 of 58 cases. False Positive Rate (FPR) of FNAC after NAC was 12%, False Negative Rate (FNR) — 58%, sensitivity — 54%, specificity — 82%, accuracy 62%. FNAC after NAC had low FPR and was found to be useful in predicting residual axillary disease and to streamline surgical decision making regarding ALND. However, FNR was unacceptably high and FNAC alone was not able to predict ypCR and omission of further axillary surgery.

scholarly journals Axillary ultrasound and fine-needle aspiration cytology to predict clinically relevant nodal burden in breast cancer patients

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Isabela Panzeri Carlotti Buzatto ◽  
Francisco José Cândido dos Reis ◽  
Jurandyr Moreira de Andrade ◽  
Tamara Cristina Gomes Ferraz Rodrigues ◽  
Jéssica Maria Camargo Borba ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Lymph Node ◽  
Fine Needle Aspiration ◽  
Axillary Lymph Node ◽  
Needle Aspiration ◽  
Axillary Lymph ◽  
Axillary Ultrasound ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology

Abstract Background Axillary lymph node involvement is one important prognostic factor in breast cancer, but the way to access this information has been modified over the years. This study evaluated if axillary ultrasound (US) coupled with fine-needle aspiration cytology (FNAC) can accurately predict clinically relevant node metastasis in patients with breast cancer, and thus assist clinical decisions Methods This is a cross-sectional study with retrospective data collection of 241 individuals (239 women and 2 men) with unilateral operable breast cancer who were submitted to preoperative axillary assessment by physical exam, US and FNAC if suspicious nodes by imaging. We calculated sensitivity, specificity, and accuracy of the methods. We compared the patient's characteristics using chi-square test, parametrics and non-parametrics statistics according to the variable. Results The most sensible method was US (0.59; 95% CI, 0.50–0.69), and the most specific was US coupled with FNAC (0.97; 95% CI, 0.92–0.99). Only 2.7% of the patients with normal axillary US had more than 2 metastatic nodes in the axillary lymph node dissection, against 50% of the patients with suspicious lymph nodes in the US and positive FNAC. Conclusions Axillary US coupled with FNAC can sort patients who have a few metastatic nodes at most from those with heavy axillary burden and could be one more tool to initially evaluate patients and define treatment strategies.

scholarly journals The New Role of Cytomorphology from Ultrasound-Guided Fine Needle Aspiration Cytology in Evaluating the Status of Prognostic Factors Including Estrogen Receptor, Progesterone Receptor and HER2 in Breast Cancer

2021 ◽  
Author(s):  
Yunzhu Li ◽  
Jiayu Li ◽  
Shijun Jia ◽  
Yuqi Yao ◽  
Yehan Zhou ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Estrogen Receptor ◽  
Prognostic Factors ◽  
Needle Aspiration ◽  
Ultrasound Guided ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
The Status ◽  
Needle Aspiration Cytology ◽  
New Scoring

Abstract Purpose It is well established that estrogen receptor (ER), progesterone receptor (PR) and human epidermal growth factor receptor (HER2) have therapeutic implications cand could be regarded as prognostic factors in breast cancer. Ultrasound-guided fine needle aspiration cytology (FNAC) has revolutionized the management of cancers, providing less invasive and quick diagnostic method. There are hardly studies on the correlation between cytomorphology and three prognostic markers. Methods We retrospectively analyzed the immunohistochemistry and fluorescence in situ hybridization of axillary lymph node specimen from 252 patients, who have been diagnosed as breast cancer at Sichuan Cancer Hospital. Morphologic features of cytology sections were scored. The relationship between cytological features and three markers were analyzed. Based on this, we developed a new system to predict the status of markers.Results The results indicated that some cytological parameters, especially the features of nucleoli, were distinctively related to the makers’ expression. In the new scoring system, a cutoff of 12.5 provided a statistical discrimination for cytological grading. Meanwhile, it was associated with higher sensitivity for evaluating the ER and PR status (94% and 86%, respectively), but a lower sensitivity for HER2 status (76%). Conclusions We concluded that cytomorphological features are associated with three prognostic factors. The HR+ tumors showed scattered micro-nucleoli, while HER2-amplication tumors demonstrated centered macro-nucleoli. Based on this, we summarized six parameters to form a new scoring system to predict the status of three factors. This may help us to broaden the application of breast cancer cytology.

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