Sensitivity of Whole-Blood Interferon-Gamma Release Assay According to the Severity and the Location of Disease in Patients with Active Tuberculosis

2011 ◽  
Vol 70 (2) ◽  
pp. 125 ◽  
Author(s):  
Yi Young Kim ◽  
Jaehee Lee ◽  
Yoon Jee Lee ◽  
So Yeon Lee ◽  
Yong Hun Lee ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Whole Blood ◽  
Active Tuberculosis ◽  
Interferon Gamma Release Assay ◽  
Release Assay

scholarly journals Whole-Blood Interferon-Gamma Release Assay for Diagnosis of Tuberculous Lymphadenitis

2011 ◽  
Vol 224 (3) ◽  
pp. 189-193 ◽  
Author(s):  
Young Keun Kim ◽  
Young Uh ◽  
Nam Seok Lee ◽  
Mee Yon Cho ◽  
Minseob Eom ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Whole Blood ◽  
Interferon Gamma Release Assay ◽  
Tuberculous Lymphadenitis ◽  
Release Assay

Usefulness of the whole-blood interferon-gamma release assay for diagnosis of extrapulmonary tuberculosis

2009 ◽  
Vol 63 (2) ◽  
pp. 182-187 ◽  
Author(s):  
Kyoung-Ho Song ◽  
Jae Hyun Jeon ◽  
Wan Beom Park ◽  
Sung-Han Kim ◽  
Kyoung Un Park ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Whole Blood ◽  
Extrapulmonary Tuberculosis ◽  
Interferon Gamma Release Assay ◽  
Release Assay

scholarly journals Tuberculosis Screening for People With Chronic Conditions

2021 ◽  
Vol 1 (5) ◽  
Author(s):  
Kendra Brett ◽  
Melissa Severn
Keyword(s):  
Immune System ◽  
Interferon Gamma ◽  
Chronic Conditions ◽  
Active Tuberculosis ◽  
Tuberculosis Infection ◽  
Interferon Gamma Release Assay ◽  
People Living With Hiv ◽  
Solid Organ ◽  
Cell Transplant ◽  
Release Assay

Five guidelines were identified that provide recommendations about screening for tuberculosis in people with chronic conditions. These guidelines cover populations with HIV, psoriasis vulgaris, solid organ and stem transplants, chronic inflammation, and compromised immune systems. Three guidelines recommend regularly screening for latent and active tuberculosis in people diagnosed with HIV or those taking medication that suppresses their immune system. One guideline for patients with psoriasis recommends using interferon-gamma release assay and a chest X-ray to rule out tuberculosis infection before immunosuppressant treatment is initiated and during treatment. Two guidelines recommend using both the interferon-gamma release assay and the tuberculin skin test at the same time to screen for latent tuberculosis infection in people with HIV, people with or who need an organ or stem cell transplant, and in people taking medication that suppresses their immune system. One guideline for people living with HIV recommends using a rapid nucleic acid amplification test to confirm clinical suspicions of active tuberculosis in these patients.

scholarly journals A Bayesian analysis of a Test and Vaccinate or Remove study to control bovine tuberculosis in badgers (Meles meles)

PLoS ONE ◽  
2021 ◽  
Vol 16 (1) ◽  
pp. e0246141
Author(s):  
Mark E. Arnold ◽  
Emily A. Courcier ◽  
Lesley A. Stringer ◽  
Carl M. McCormick ◽  
Ana V. Pascual-Linaza ◽  
...  
Keyword(s):  
Real Time ◽  
Diagnostic Test ◽  
Interferon Gamma ◽  
Whole Blood ◽  
Latent Class ◽  
Meles Meles ◽  
Interferon Gamma Release Assay ◽  
Infection Prevalence ◽  
Test Characteristics ◽  
Release Assay

A novel five year Test and Vaccinate or Remove (TVR) wildlife research intervention project in badgers (Meles meles) commenced in 2014 in a 100km2 area of Northern Ireland. It aimed to increase the evidence base around badgers and bovine TB and help create well-informed and evidence-based strategies to address the issue of cattle-to-cattle spread and spread between cattle and badgers. It involved real-time trap-side testing of captured badgers and vaccinating those that tested negative for bTB (BadgerBCG–BCG Danish 1331) and removal of those that tested bTB positive using the Dual-Path Platform VetTB test (DPP) for cervids (Chembio Diagnostic Systems, Medford, NY USA). Four diagnostic tests were utilised within the study interferon gamma release assay (IGRA), culture (clinical samples and post mortem), DPP using both whole blood and DPP using serum. BCG Sofia (SL222) was used in the final two years because of supply issues with BadgerBCG. Objectives for this study were to evaluate the performance of the DPP in field conditions and whether any trend was apparent in infection prevalence over the study period. A Bayesian latent class model of diagnostic test evaluation in the absence of a gold standard was applied to the data. Temporal variation in the sensitivity of DPP and interferon gamma release assay (IGRA) due to the impact of control measures was investigated using logistic regression and individual variability was assessed. Bayesian latent class analysis estimated DPP with serum to have a sensitivity of 0.58 (95% CrI: 0.40–0.76) and specificity of 0.97 (95% CrI: 0.95–0.98). The DPP with whole blood showed a higher sensitivity (0.69 (95% CrI: 0.48–0.88)) but similar specificity (0.98 (95% Crl: 0.96–0.99)). The change from BCG Danish to BCG Sofia significantly impacted on DPP serum test characteristics. In addition, there was weak evidence of increasing sensitivity of IGRA over time and differences in DPP test sensitivity between adults and cubs. An exponential decline model was an appropriate representation of the infection prevalence over the 5 years, with a starting prevalence of 14% (95% CrI: 0.10–0.20), and an annual reduction of 39.1% (95% CrI: 26.5–50.9). The resulting estimate of infection prevalence in year 5 of the study was 1.9% (95% CrI: 0.8–3.8). These results provide field evidence of a statistically significant reduction in badger TB prevalence supporting a TVR approach to badger intervention. They give confidence in the reliability and reproducibility in the DPP Whole Blood as a real time trap-side diagnostic test for badgers, and describe the effect of vaccination and reduced infection prevalence on test characteristics.

scholarly journals Evaluation of an interferon-gamma release assay in young contacts of active tuberculosis cases

2011 ◽  
Vol 17 (09) ◽  
pp. 714-718 ◽  
Author(s):  
S. Noorbakhsh ◽  
J. Mousavi ◽  
M. Barati ◽  
A.R. Shamshiri ◽  
M. Shekarabi ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Active Tuberculosis ◽  
Interferon Gamma Release Assay ◽  
Release Assay

The Effect of Age on Whole Blood Interferon-Gamma Release Assay Response among Children Investigated for Latent Tuberculosis Infection

2012 ◽  
Vol 161 (4) ◽  
pp. 632-638 ◽  
Author(s):  
Elena Critselis ◽  
Virginia Amanatidou ◽  
Garyfallia Syridou ◽  
Nikos P. Spyridis ◽  
Mersini Mavrikou ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Whole Blood ◽  
Latent Tuberculosis Infection ◽  
Latent Tuberculosis ◽  
Tuberculosis Infection ◽  
Interferon Gamma Release Assay ◽  
Release Assay ◽  
Effect Of Age

Analysis of predictors influencing indeterminate whole-blood interferon-gamma release assay results in patients with rheumatic diseases

2014 ◽  
Vol 34 (12) ◽  
pp. 1711-1720 ◽  
Author(s):  
Hyun-Ju Jung ◽  
Tae-Jong Kim ◽  
Hyoung-Sang Kim ◽  
Young-Nan Cho ◽  
Hye-Mi Jin ◽  
...  
Keyword(s):  
Interferon Gamma ◽  
Rheumatic Diseases ◽  
Whole Blood ◽  
Interferon Gamma Release Assay ◽  
Release Assay
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