Gene Expression Profile of Lung Cancer Cells Following Photodynamic Therapy

2007 ◽  
Vol 63 (1) ◽  
pp. 52
Author(s):  
Ji Hyun Sung ◽  
Mi-Eun Lee ◽  
Seon-Sook Han ◽  
Seung-Joon Lee ◽  
Kwon-Soo Ha ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Cancer Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Lung Cancer Cells

Human lung cancer cells and tissues partially recapitulate the homeobox gene expression profile of embryonic lung

Lung Cancer ◽  
2002 ◽  
Vol 37 (1) ◽  
pp. 41-47 ◽  
Author(s):  
John F. Lechner ◽  
Yongxin Wang ◽  
Fauzia Siddiq ◽  
Joseph M. Fugaro ◽  
Anil Wali ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Cancer Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Human Lung ◽  
Homeobox Gene ◽  
Human Lung Cancer ◽  
Embryonic Lung ◽  
Human Lung Cancer Cells

scholarly journals AS601245, an Anti-Inflammatory JNK Inhibitor, and Clofibrate Have a Synergistic Effect in Inducing Cell Responses and in Affecting the Gene Expression Profile in CaCo-2 Colon Cancer Cells

PPAR Research ◽  
2012 ◽  
Vol 2012 ◽  
pp. 1-16 ◽  
Author(s):  
Angelo Cerbone ◽  
Cristina Toaldo ◽  
Stefania Pizzimenti ◽  
Piergiorgio Pettazzoni ◽  
Chiara Dianzani ◽  
...  
Keyword(s):  
Gene Expression ◽  
Colon Cancer ◽  
Cell Proliferation ◽  
Cancer Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Combined Treatment ◽  
Colon Cancer Cells ◽  
Positive Interaction ◽  
Anti Inflammatory

PPARαs are nuclear receptors highly expressed in colon cells. They can be activated by the fibrates (clofibrate, ciprofibrate etc.) used to treat hyperlipidemia. Since PPARαtranscriptional activity can be negatively regulated by JNK, the inhibition of JNK activity could increase the effectiveness of PPARαligands. We analysed the effects of AS601245 (a JNK inhibitor) and clofibrate alone or in association, on proliferation, apoptosis, differentiation and the gene expression profile of CaCo-2 human colon cancer cells. Proliferation was inhibited in a dose-dependent way by clofibrate and AS601245. Combined treatment synergistically reduced cell proliferation, cyclin D1 and PCNA expression and induced apoptosis and differentiation. Reduction of cell proliferation, accompanied by the modulation of p21 expression was observed in HepG2 cells, also. Gene expression analysis revealed that some genes were highly modulated by the combined treatment and 28 genes containing PPRE were up-regulated, while clofibrate alone was ineffective. Moreover, STAT3 signalling was strongly reduced by combined treatment. After combined treatment, the binding of PPARαto PPRE increased and paralleled with the expression of the PPAR coactivator MED1. Results demonstrate that combined treatment increases the effectiveness of both compounds and suggest a positive interaction between PPARαligands and anti-inflammatory agents in humans.

Abstract 3931: Neratinib-induced gene expression profile in breast cancer cells: A comprehensive transcriptome investigation

2018 ◽  
Author(s):  
Yuxin Cui ◽  
Alwyn Dart ◽  
Richard E. Cutler ◽  
Alshad S. Lalani ◽  
Francesca Avogadri-Connors ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Gene Expression ◽  
Cancer Cells ◽  
Gene Expression Profile ◽  
Expression Profile ◽  
Breast Cancer Cells

Overcoming the diverse mechanisms of multidrug resistance in lung cancer cells by photodynamic therapy using pTHPP-loaded PLGA-lipid hybrid nanoparticles

2020 ◽  
Vol 149 ◽  
pp. 218-228 ◽  
Author(s):  
Sasivimon Pramual ◽  
Kriengsak Lirdprapamongkol ◽  
Valérie Jouan-Hureaux ◽  
Muriel Barberi-Heyob ◽  
Céline Frochot ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Photodynamic Therapy ◽  
Multidrug Resistance ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Hybrid Nanoparticles

scholarly journals The Marine Dinoflagellate Alexandrium minutum Activates a Mitophagic Pathway in Human Lung Cancer Cells

Marine Drugs ◽  
2018 ◽  
Vol 16 (12) ◽  
pp. 502 ◽  
Author(s):  
Christian Galasso ◽  
Genoveffa Nuzzo ◽  
Christophe Brunet ◽  
Adrianna Ianora ◽  
Angela Sardo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Cancer Cells ◽  
Human Lung ◽  
Water Soluble ◽  
Lung Cancer Cells ◽  
Human Lung Cancer ◽  
Normal Lung ◽  
Alexandrium Minutum ◽  
Human Lung Cancer Cells

Marine dinoflagellates are a valuable source of bioactive molecules. Many species produce cytotoxic compounds and some of these compounds have also been investigated for their anticancer potential. Here, we report the first investigation of the toxic dinoflagellate Alexandrium minutum as source of water-soluble compounds with antiproliferative activity against human lung cancer cells. A multi-step enrichment of the phenol–water extract yielded a bioactive fraction with specific antiproliferative effect (IC50 = 0.4 µg·mL−1) against the human lung adenocarcinoma cells (A549 cell line). Preliminary characterization of this material suggested the presence of glycoprotein with molecular weight above 20 kDa. Interestingly, this fraction did not exhibit any cytotoxicity against human normal lung fibroblasts (WI38). Differential gene expression analysis in A549 cancer cells suggested that the active fraction induces specific cell death, triggered by mitochondrial autophagy (mitophagy). In agreement with the cell viability results, gene expression data also showed that no mitophagic event was activated in normal cells WI38.

scholarly journals Silibinin-loaded magnetic nanoparticles inhibit hTERT gene expression and proliferation of lung cancer cells

2017 ◽  
Vol 45 (8) ◽  
pp. 1649-1656 ◽  
Author(s):  
Soumaye Amirsaadat ◽  
Younes Pilehvar-Soltanahmadi ◽  
Faraz Zarghami ◽  
Shahriar Alipour ◽  
Zohreh Ebrahimnezhad ◽  
...  
Keyword(s):  
Gene Expression ◽  
Lung Cancer ◽  
Magnetic Nanoparticles ◽  
Cancer Cells ◽  
Lung Cancer Cells ◽  
Htert Gene
Sign in / Sign up

Export Citation Format

Share Document