Understanding Noises from Different Flow Mediums in Near Well Bore Region: A Novel Approach for Detection and Characterisation of Sub-Vertical Natural Flow Paths in North Kuwait Gas Fields

2016 ◽  
Author(s):  
M. N. Acharya ◽  
A. Al-Mershed ◽  
S. R. Narhari ◽  
M. Al-Azmi ◽  
Q. M. Dashti ◽  
...  
2020 ◽  
Author(s):  
Stanislav Ursegov ◽  
Armen Zakharian

<p>This work shows that the traditional version of geological models of oil and gas fields obtained by a computer approach is not the only possible one and it prevents the development of modeling as a whole, since it is not truly mathematical.</p><p>Given that computers do not work with images, but with numbers, a novel approach is presented for the construction of truly mathematical geological models. The proposed model has an unusual appearance and is not intended for visual analysis, but it is more effective for forecasting. The mathematical basis of the novel approach is the cascades of fuzzy-logical matrices, which are formed from spatial coordinates and considered geological parameters.</p><p>Suppose that for each point in the geological grid there is a coordinate vector, in the simplest case these are the lateral coordinates X and Y, as well as the vertical coordinate Z. There is also a set of points (wells) at which the specified coordinates and the values of considered geological parameter, for example, porosity or oil saturation are determined. If some seismic parameter is added to them, which can be taken from grids constructed according to seismic data at the points of the wells, then four coordinates become available.</p><p>Preliminary, all considered geological parameters should be normalized in the range from -1.0 to + 1.0 in order to standardize and equalize them.</p><p>Four coordinates give six independent pairs. A matrix is constructed for each of these pairs. The matrix size can be different - from 100 per 100 to 1000 per 1000.</p><p>Next, the values of the considered geological parameter at the well points determined by four coordinates are applied to these matrices. Certainly, such points are much smaller than the points in the matrix, therefore, to fill the entire polygon of the matrix, the interpolation method is used, based on the idea of the lattice Boltzmann equations.</p><p>The number of fuzzy-logical matrices in one geological model can reach several hundreds.</p><p>Using the obtained matrices, one can construct membership functions and predict the values of the selected geological parameters, as well as the distribution of initial hydrocarbon reserves or the effectiveness of new drilling at the field.</p><p>The novel approach to geological modeling based on the cascades of fuzzy-logical matrices may seem complicated. However, the calculation of these cascades is carried out completely automatically, since they are the truly mathematical functions, and not the illustrations of the geological structure of the filed, and they are directly used in forecasting calculations.</p><p>The cascades of fuzzy-logical matrices can be considered as a new form of machine learning algorithms, for which it is advisable to use big data sets. It opens up the additional possibilities for the application of machine learning methods in geological modeling of oil and gas fields with conventional and unconventional reserves.</p>


1998 ◽  
Author(s):  
K.R. Stephens ◽  
B.F. Ronalds ◽  
E.J. Piermattei
Keyword(s):  

2019 ◽  
Vol 476 (24) ◽  
pp. 3705-3719 ◽  
Author(s):  
Avani Vyas ◽  
Umamaheswar Duvvuri ◽  
Kirill Kiselyov

Platinum-containing drugs such as cisplatin and carboplatin are routinely used for the treatment of many solid tumors including squamous cell carcinoma of the head and neck (SCCHN). However, SCCHN resistance to platinum compounds is well documented. The resistance to platinum has been linked to the activity of divalent transporter ATP7B, which pumps platinum from the cytoplasm into lysosomes, decreasing its concentration in the cytoplasm. Several cancer models show increased expression of ATP7B; however, the reason for such an increase is not known. Here we show a strong positive correlation between mRNA levels of TMEM16A and ATP7B in human SCCHN tumors. TMEM16A overexpression and depletion in SCCHN cell lines caused parallel changes in the ATP7B mRNA levels. The ATP7B increase in TMEM16A-overexpressing cells was reversed by suppression of NADPH oxidase 2 (NOX2), by the antioxidant N-Acetyl-Cysteine (NAC) and by copper chelation using cuprizone and bathocuproine sulphonate (BCS). Pretreatment with either chelator significantly increased cisplatin's sensitivity, particularly in the context of TMEM16A overexpression. We propose that increased oxidative stress in TMEM16A-overexpressing cells liberates the chelated copper in the cytoplasm, leading to the transcriptional activation of ATP7B expression. This, in turn, decreases the efficacy of platinum compounds by promoting their vesicular sequestration. We think that such a new explanation of the mechanism of SCCHN tumors’ platinum resistance identifies novel approach to treating these tumors.


2020 ◽  
Vol 51 (3) ◽  
pp. 544-560 ◽  
Author(s):  
Kimberly A. Murphy ◽  
Emily A. Diehm

Purpose Morphological interventions promote gains in morphological knowledge and in other oral and written language skills (e.g., phonological awareness, vocabulary, reading, and spelling), yet we have a limited understanding of critical intervention features. In this clinical focus article, we describe a relatively novel approach to teaching morphology that considers its role as the key organizing principle of English orthography. We also present a clinical example of such an intervention delivered during a summer camp at a university speech and hearing clinic. Method Graduate speech-language pathology students provided a 6-week morphology-focused orthographic intervention to children in first through fourth grade ( n = 10) who demonstrated word-level reading and spelling difficulties. The intervention focused children's attention on morphological families, teaching how morphology is interrelated with phonology and etymology in English orthography. Results Comparing pre- and posttest scores, children demonstrated improvement in reading and/or spelling abilities, with the largest gains observed in spelling affixes within polymorphemic words. Children and their caregivers reacted positively to the intervention. Therefore, data from the camp offer preliminary support for teaching morphology within the context of written words, and the intervention appears to be a feasible approach for simultaneously increasing morphological knowledge, reading, and spelling. Conclusion Children with word-level reading and spelling difficulties may benefit from a morphology-focused orthographic intervention, such as the one described here. Research on the approach is warranted, and clinicians are encouraged to explore its possible effectiveness in their practice. Supplemental Material https://doi.org/10.23641/asha.12290687


2015 ◽  
Vol 21 ◽  
pp. 128
Author(s):  
Kaniksha Desai ◽  
Halis Akturk ◽  
Ana Maria Chindris ◽  
Shon Meek ◽  
Robert Smallridge ◽  
...  
Keyword(s):  

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