ANTIFEEDANT AND GROWTH INHIBITORY EFFECTS OF TALL OIL AND DERIVATIVES AGAINST THE VARIEGATED CUTWORM, PERIDROMA SAUCIA HÜBNER (LEPIDOPTERA: NOCTUIDAE)

1992 ◽  
Vol 124 (5) ◽  
pp. 861-869 ◽  
Author(s):  
Yongshou Xie ◽  
Murray B. Isman
Keyword(s):  
Low Cost ◽  
Larval Growth ◽  
Control Agent ◽  
Biologically Active ◽  
Inhibitory Effects ◽  
Tall Oil ◽  
Peridroma Saucia ◽  
Growth Inhibitory ◽  
Variegated Cutworm ◽  
Environmentally Sound

AbstractCrude tall oil and two of its derivatives were assessed for antifeedant and growth inhibitory effects, via incorporation into an artificial diet, in the variegated cutworm (Peridroma saucia Hübner). The substances tested are both toxic to neonate P. saucia and inhibitory to larval growth. The dietary LC50 (lethal concentration for 50% mortality) values are 4.3, 4.7, and 5.3% fresh weight for depitched tall oil (DTO), crude tall oil (CTO), and tall oil pitch (TOP), respectively. These materials significantly reduced growth, feeding, and dietary utilization by first-, second-, third-, and fourth-instar larvae in chronic larval growth bioassays, choice and no-choice feeding tests, and nutritional experiments. The EC50s (effective concentration to inhibit growth by 50% relative to controls) of DTO, CTO, and TOP were 1.4, 2.0, and ≥2.4%, respectively, when first-instar larvae fed on treated diets for 10 days. DTO significantly reduced both growth and consumption rates with corresponding reduction in the efficiency of conversion of food (i.e. nutritional efficiency), suggesting that both antifeedant and toxic effects are involved in larval growth inhibition. DTO and CTO are consistently more biologically active than TOP. Our results suggest that an environmentally sound, low cost natural pest control agent may be developed based on tall oil.

scholarly journals A note on the chronic effects of tall oil on the variegetd cutworm, Peridroma saucia [Lepidoptera : Noctuidae]

2005 ◽  
Vol 73 (3) ◽  
pp. 119-121 ◽  
Author(s):  
Y.S. Xie ◽  
M.B. Isman
Keyword(s):  
Developmental Time ◽  
Inhibitory Effect ◽  
Kraft Pulping ◽  
Diet Shift ◽  
Tall Oil ◽  
Peridroma Saucia ◽  
Chronic Effects ◽  
Dietary Concentration ◽  
Variegated Cutworm ◽  
Shift Experiment

Chronic effects of tall oil, a by-product of the kraft pulping process of softwoods, on the variegated cutworm, Peridroma saucia, were assessed via incorporation into artificial diet. At a dietary concentration of 1.5% fresh weight, depitched tall oil (DTO) significantly reduced P. saucia weight, prolonged developmental time, and increased mortality in different stages. A significant linear relationship was found between dietary concentration of DTO and ail developmental parameters tested. A diet-shift experiment clearly demonstrated that the inhibitory effect of DTO to P. saucia is persistent and not readily alleviated by transferring larvae to untreated diet. DTO may be a useful natural agent for pest management.

Tools of Transformation: Appropriate Technology in U.S. Countercultural Literature

2012 ◽  
Vol 44 (2) ◽  
pp. 75-93
Author(s):  
Peter Mortensen
Keyword(s):  
Low Cost ◽  
Appropriate Technology ◽  
Small Scale ◽  
Environmental Transformation ◽  
Buckminster Fuller ◽  
1960S And 1970S ◽  
The 1960S ◽  
Environmentally Sound ◽  
User Friendly ◽  
Second Wave

This essay takes its cue from second-wave ecocriticism and from recent scholarly interest in the “appropriate technology” movement that evolved during the 1960s and 1970s in California and elsewhere. “Appropriate technology” (or AT) refers to a loosely-knit group of writers, engineers and designers active in the years around 1970, and more generally to the counterculture’s promotion, development and application of technologies that were small-scale, low-cost, user-friendly, human-empowering and environmentally sound. Focusing on two roughly contemporary but now largely forgotten American texts Sidney Goldfarb’s lyric poem “Solar-Heated-Rhombic-Dodecahedron” (1969) and Gurney Norman’s novel Divine Right’s Trip (1971)—I consider how “hip” literary writers contributed to eco-technological discourse and argue for the 1960s counterculture’s relevance to present-day ecological concerns. Goldfarb’s and Norman’s texts interest me because they conceptualize iconic 1960s technologies—especially the Buckminster Fuller-inspired geodesic dome and the Volkswagen van—not as inherently alienating machines but as tools of profound individual, social and environmental transformation. Synthesizing antimodernist back-to-nature desires with modernist enthusiasm for (certain kinds of) machinery, these texts adumbrate a humanity- and modernity-centered post-wilderness model of environmentalism that resonates with the dilemmas that we face in our increasingly resource-impoverished, rapidly warming and densely populated world.

scholarly journals Growth Inhibitory Effects of Ester Derivatives of Menahydroquinone-4, the Reduced Form of Vitamin K2(20), on All-Trans Retinoic Acid-Resistant HL60 Cell Line

Pharmaceutics ◽  
2021 ◽  
Vol 13 (5) ◽  
pp. 758
Author(s):  
Hirofumi Yamakawa ◽  
Shuichi Setoguchi ◽  
Shotaro Goto ◽  
Daisuke Watase ◽  
Kazuki Terada ◽  
...  
Keyword(s):  
Retinoic Acid ◽  
Adverse Effects ◽  
Vitamin K2 ◽  
Reduced Form ◽  
Inhibitory Effects ◽  
Hl60 Cells ◽  
Trans Retinoic Acid ◽  
All Trans Retinoic Acid ◽  
Growth Inhibitory ◽  
Derivatives Of

The first-choice drug for acute promyelocytic leukemia (APL), all-trans retinoic acid (ATRA), frequently causes drug-resistance and some adverse effects. Thus, an effective and safe agent for ATRA-resistant APL is needed. Menaquinone-4 (MK-4, vitamin K2(20)), used for osteoporosis treatment, does not have serious adverse effects. It has been reported that MK-4 has growth-inhibitory effects on HL60 cells by inducing apoptosis via the activation of Bcl-2 antagonist killer 1 (BAK). However, the effect of MK-4 on ATRA-resistant APL has not been reported. Here, we show that ester derivatives of menahydroquinone-4 (MKH; a reduced form of MK-4), MKH 1,4-bis-N,N-dimethylglycinate (MKH-DMG) and MKH 1,4-bis-hemi-succinate (MKH-SUC), exerted strong growth-inhibitory effects even on ATRA-resistant HL60 (HL-60R) cells compared with ATRA and MK-4. MKH delivery after MKH-SUC treatment was higher than that after MK-4 treatment, and the results indicated apoptosis induced by BAK activation. In contrast, for MKH-DMG, reconversion to MKH was slow and apoptosis was not observed. We suggest that the ester forms, including monoesters of MKH-DMG, exhibit another mechanism independent of apoptosis. In conclusion, the MKH derivatives (MKH-SUC and MKH-DMG) inhibited not only HL60 cells but also HL-60R cells, indicating a potential to overcome ATRA resistance.

scholarly journals Trichostatin A downregulates bromodomain and extra-terminal proteins to suppress osimertinib resistant non-small cell lung carcinoma

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yuting Meng ◽  
Xixi Qian ◽  
Li Zhao ◽  
Nan Li ◽  
Shengjie Wu ◽  
...  
Keyword(s):  
Trichostatin A ◽  
Small Cell Lung Carcinoma ◽  
Cell Types ◽  
Inhibitory Effects ◽  
Cell Lung Carcinoma ◽  
Growth Inhibitory ◽  
Terminal Proteins ◽  
P Cells

Abstract Background The third-generation epithelial growth factor receptor tyrosine kinase inhibitors (EGFR-TKIs) have shown significant therapeutic effects on patients with non-small cell lung carcinoma (NSCLC) who carry active EGFR mutations, as well as those who have developed acquired resistance to the first-generation of EGFR-TKIs due to the T790M mutation. However, most patients develop drug resistance after 8–10 months of treatment. Currently, the mechanism has not been well clarified, and new therapeutic strategies are urgently needed. Methods Osimertinib resistant cell lines were established by culturing sensitive cells in chronically increasing doses of osimertinib. The anticancer effect of reagents was examined both in vitro and in vivo using the sulforhodamine B assay and a xenograft mouse model. The molecular signals were detected by western blotting. The combination effect was analyzed using CompuSyn software. Results We found that bromodomain and extra-terminal proteins (BETs) were upregulated in osimertinib resistant (H1975-OR) cells compared with those in the paired parental cells (H1975-P), and that knockdown of BETs significantly inhibited the growth of H1975-OR cells. The BET inhibitor JQ1 also exhibited stronger growth-inhibitory effects on H1975-OR cells and a greater expression of BETs and the downstream effector c-Myc than were observed in H1975-P cells. The histone deacetylase (HDAC) inhibitor trichostatin A (TSA) showed stronger growth suppression in H1975-OR cells than in H1975-P cells, but vorinostat, another HDAC inhibitor, showed equal inhibitory efficacy in both cell types. Consistently, downregulation of BET and c-Myc expression was greater with TSA than with vorinostat. TSA restrained the growth of H1975-OR and H1975-P xenograft tumors. The combination of TSA and JQ1 showed synergistic growth-inhibitory effects in parallel with decreased BET and c-Myc expression in both H1975-OR and H1975-P cells and in xenograft nude mouse models. BETs were not upregulated in osimertinib resistant HCC827 cells compared with parental cells, while TSA and vorinostat exhibited equal inhibitory effects on both cell types. Conclusion Upregulation of BETs contributed to the osimertinib resistance of H1975 cells. TSA downregulated BET expression and enhanced the growth inhibitory effect of JQ1 both in vitro and in vivo. Our findings provided new strategies for the treatment of osimertinib resistance.

The physiology of teichoic acid deficient staphylococci

1973 ◽  
Vol 19 (11) ◽  
pp. 1393-1399 ◽  
Author(s):  
Li-Tse Ou ◽  
A. N. Chatterjee ◽  
F. E. Young ◽  
R. E. Marquis
Keyword(s):  
Cell Walls ◽  
Parent Strain ◽  
Teichoic Acid ◽  
Low Ph ◽  
Aureus Strain ◽  
Binding Affinities ◽  
Inhibitory Effects ◽  
Growth Inhibitory ◽  
Acid Titration ◽  
Phosphate Groups

Cell walls isolated from a teichoic acid deficient mutant (52A5) of Staphylococcus aureus strain H were found to have lower capacities to bind cations than did walls of the parent strain. Both types of walls had higher binding affinities for Mg2+ and Ca2+ than for K+ and Na+. The reduced number of phosphate groups in 52A5 walls was reflected in a higher apparent pKa of 4.3 for displacement of Mg2+ (or Ca2+) during acid titration with HCl. The comparable pKa value for displacement of bound Mg2+ from parent-strain walls was 3.7. The reduced capacity of 52A5 walls to bind cations was not reflected in any significant increase in sensitivity to the growth inhibitory actions of ethylenediaminetetraacetate, low pH, or high NaCl concentrations. However, the 52A5 strain was somewhat more sensitive to the inhibitory effects of high pH. Also, mutant walls were found to be structurally more compact than walls of the parent strain, presumably because of less extensive electrostatic repulsion within the wall matrix.

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