Pharmacological Considerations in Human Immunodeficiency Virus–Infected Adults in the Intensive Care Unit

2013 ◽  
Vol 33 (2) ◽  
pp. 46-56 ◽  
Author(s):  
Ashley A. DeFreitas ◽  
Theresa-Lynda M. D’Souza ◽  
Ginille J. Lazaro ◽  
Emily M. Windes ◽  
Melissa D. Johnson ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Human Immunodeficiency Virus ◽  
Intensive Care ◽  
Immunodeficiency Virus

scholarly journals Acute Human Immunodeficiency Virus (HIV) Infection Presenting With Bilateral Interstitial Pneumonia: Case Report and Discussion of Potential HIV-Induced Interstitial Pneumonia

2017 ◽  
Vol 4 (4) ◽  
Author(s):  
Anna Maria Peri ◽  
Laura Alagna ◽  
Serena Trovati ◽  
Francesca Sabbatini ◽  
Roberto Rona ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Human Immunodeficiency Virus ◽  
Intensive Care ◽  
Case Report ◽  
Interstitial Pneumonia ◽  
Antiretroviral Treatment ◽  
Pneumonia Case ◽  
Immunodeficiency Virus ◽  
Acute Hiv ◽  
Hiv 1

Abstract A 50-year-old man was admitted to intensive care unit because of acute respiratory failure due interstitial pneumonia; after admission, a diagnosis of acute human immunodeficiency virus (HIV)-1 infection was made. Clinical and radiological improvement was observed only after introduction of antiretroviral treatment. We discuss the hypothesis of interstitial pneumonia induced by the acute HIV-1 infection.

scholarly journals HIV treatment non-adherence is associated with ICU mortality in HIV-positive critically ill patients

2020 ◽  
pp. 175114371989897 ◽  
Author(s):  
Nelson BF Neto ◽  
Luiz G Marin ◽  
Bruna G de Souza ◽  
Ana LD Moro ◽  
Wagner L Nedel
Keyword(s):  
Intensive Care Unit ◽  
Human Immunodeficiency Virus ◽  
Intensive Care ◽  
Antiretroviral Therapy ◽  
Intensive Care Unit Admission ◽  
Hospital Mortality ◽  
Intensive Care Units ◽  
Therapy Adherence ◽  
Antiretroviral Therapy Adherence ◽  
Immunodeficiency Virus

Introduction Combined antiretroviral therapy has led to significant decreases in morbidity and mortality in acquired immunodeficiency syndrome patients. Survival among these patients admitted to intensive care units has also improved in the last years. However, the prognostic predictors of human immunodeficiency vírus patients in intensive care units have not been adequately studied. The main objective of this study was to evaluate if non-adherence to antiretroviral therapy is a predictor of hospital mortality. Methods A unicentric, retrospective, cohort study composed of patients admitted to a 59-bed mixed intensive care unit including all patients with human immunodeficiency vírus infection. Patients were excluded if exclusive palliative care was established before completing 48 h of intensive care unit admission. Clinical and treatment data were obtained, including demographic records, underlying diseases, Simplified Acute Physiology III score at the time of intensive care unit admission, CD4 lymphocyte count, antiretroviral therapy adherence, admission diagnosis, human immunodeficiency vírus-related diseases, sepsis and use of mechanical ventilation and hemodialysis. The outcome analyzed was hospital mortality. Results Overall, 167 patients were included in the study, and intensive care unit mortality was 34.7%. Multivariate analysis indicated that antiretroviral therapy adherence and the Simplified Acute Physiology 3 score were independently related to hospital mortality. antiretroviral therapy adherence was a protective factor (OR 0.2; 95% CI 0.05–0.71; P = 0.01), and Simplified Acute Physiology 3 (OR 1.04; 95% CI 1.01–1.08; P < 0.01) was associated with increased hospital mortality. Conclusion Non-adherence to antiretroviral therapy is associated with hospital mortality in this population. Highly active antiretroviral therapy non-adherence may be associated with other comorbidities that may be associated with a worst prognosis in this scenario.

scholarly journals Impact of an Antiretroviral Stewardship Team on the Care of Patients With Human Immunodeficiency Virus Infection Admitted to an Academic Medical Center

2019 ◽  
Vol 6 (7) ◽  
Author(s):  
Ashley M DePuy ◽  
Rafik Samuel ◽  
Kerry M Mohrien ◽  
Elijah B Clayton ◽  
David E Koren
Keyword(s):  
Risk Factors ◽  
Intensive Care Unit ◽  
Human Immunodeficiency Virus ◽  
Intensive Care ◽  
Medical Center ◽  
Academic Medical Center ◽  
Cost Savings ◽  
Intensive Care Unit Care ◽  
Documentation System ◽  
Immunodeficiency Virus

Abstract Background Interdisciplinary antiretroviral stewardship teams, comprising a human immunodeficiency virus pharmacist specialist, an infectious diseases physician, and associated learners, have the ability to assist in identification and correction of inpatient antiretroviral-related errors. Methods Electronic medical records of patients with antiretroviral orders admitted to our hospital were evaluated for the number of interventions made by the stewardship team, number of admissions with errors identified, risk factors for occurrence of errors, and cost savings. Risk factors were analyzed by means of multivariable logistic regression. Cost savings were estimated by the documentation system Clinical Measures. Results A total of 567 admissions were included for analysis in a 1-year study period. Forty-three percent of admissions (245 of 567) had ≥1 intervention, with 336 interventions in total. The following were identified as risk factors for error: multitablet inpatient regimen (odds ratio, 1.834; 95% confidence interval, 1.160–2.899; P = .009), admission to the intensive care unit (2.803; 1.280–6.136; P = .01), care provided by a surgery service (1.762; 1.082–2.868; P = .02), increased number of days reviewed (1.061; 1.008–1.117; P = .02), and noninstitutional outpatient provider (1.375; .972–1.946; P = .07). The 1-year cost savings were estimated to be $263 428. Conclusions Antiretroviral stewardship teams optimize patient care through identification and correction of antiretroviral-related errors. Errors may be more common in patients with multitablet inpatient regimens, admission to the intensive care unit, care provided by a surgery service, and increased number of hospital days reviewed. Once antiretroviral-related errors are identified, the ability to correct them provides cost savings.

929: DRUG INTERACTIONS IN HUMAN IMMUNODEFICIENCY VIRUS (HIV)-INFECTED INTENSIVE CARE UNIT (ICU) PATIENTS

2018 ◽  
Vol 46 (1) ◽  
pp. 448-448
Author(s):  
Jackie Johnston ◽  
Mojdeh Heavner ◽  
Cheuk Hei (Michael) Liu ◽  
Jeffrey Topal ◽  
Gianna Casal ◽  
...  
Keyword(s):  
Intensive Care Unit ◽  
Human Immunodeficiency Virus ◽  
Intensive Care ◽  
Drug Interactions ◽  
Icu Patients ◽  
Immunodeficiency Virus
Sign in / Sign up

Export Citation Format

Share Document