scholarly journals The “Road” to Atrial Fibrillation: The Role of the Cardiac Autonomic Nervous System

2020 ◽  
Vol 13 (1) ◽  
Author(s):  
Dhanunjaya Lakkireddy
Keyword(s):  
Atrial Fibrillation ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Cardiac Autonomic Nervous System ◽  
Autonomic Nervous ◽  
The Road

scholarly journals Sleep Apnea and Atrial Fibrillation: Role of the Cardiac Autonomic Nervous System

2021 ◽  
pp. 48-51
Author(s):  
Liliana Tavares ◽  
Adi Lador ◽  
Miguel Valderrábano
Keyword(s):  
United States ◽  
Atrial Fibrillation ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Sleep Apnea ◽  
The United States ◽  
Cardiac Autonomic Nervous System ◽  
Autonomic Nervous

Sleep apnea is highly associated with atrial fibrillation (AF), and both diseases are highly prevalent in the United States. The mechanistic underpinnings that contribute to their association remain uncertain, but numerous possible mechanisms have been proposed, including dysfunction of the cardiac autonomic nervous system (ANS). Studies have reported that apnea induces hyperactivity of the ANS, leading to increases in AF susceptibility. This review compiles the latest evidence on the role of the ANS in sleep-apnea-induced AF.

ROLE OF AUTONOMIC NERVOUS SYSTEM AND RECURRENCE OF ATRIAL FIBRILLATION AFTER SUCCESSFUL CARDIOVERSION

2005 ◽  
Author(s):  
EIICHI WATANABE ◽  
TOMOHARU ARAKAWA ◽  
MAO QUIN TONG ◽  
TATSUSHI UCHIYAMA ◽  
ITSUO KODAMA ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Autonomic Nervous

Role of the Autonomic Nervous System in Atrial Fibrillation

2018 ◽  
pp. 419-425
Author(s):  
Stavros Stavrakis ◽  
Benjamin J. Scherlag ◽  
Paul Garabelli ◽  
Sunny S. Po
Keyword(s):  
Atrial Fibrillation ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Autonomic Nervous

3055Interactions between metabolism regulator adiponectin and intrinsic cardiac autonomic nervous system: a potential treatment target for atrial fibrillation

2019 ◽  
Vol 40 (Supplement_1) ◽  
Author(s):  
L Yu ◽  
Z Zhou ◽  
H Jiang
Keyword(s):  
Atrial Fibrillation ◽  
Nervous System ◽  
Autonomic Nervous System ◽  
Neural Activity ◽  
Atrial Pacing ◽  
Macrophage Phenotype ◽  
Cardiac Autonomic Nervous System ◽  
Autonomic Nervous ◽  
Phenotype Switching ◽  
Fat Pads

Abstract Background Previous studies indicated that inhibiting the cardiac autonomic nervous system (CANS) suppressed atrial fibrillation (AF). Clinical research revealed that high levels of serum adiponectin (APN) could exert a beneficial influence on sympathetic and vagal tone in patients with type 2 diabetes. The aim of this study was to elucidate whether APN could regulate CANS and subsequently suppress rapid atrial pacing (RAP)-induced AF. Methods Eighteen anesthetized male beagles were randomly divided into three groups: the control group (saline plus sham RAP, N=6), the RAP group (saline plus 3 h RAP, N=6) and the APN + RAP group (APN plus 3 h RAP, N=6). Multielectrode catheters were attached to all atria and pulmonary veins. After bilateral thoracotomy, APN (10 μg, 0.1 μg/μL) or saline was microinjected into 4 fat pads, each containing one of the major atrial ganglionated plexi (GP), prior to RAP. Electrophysiological parameters including atrial effective refractory period (ERP), cumulative window of vulnerability (ΣWOV), anterior right GP (ARGP) function and neural activity were measured at baseline and 3 h after pacing. The fat pads containing the GP were excised for molecular biological testing and pathological staining at the end of the protocol. Results Compared with the control treatment, RAP markedly shortened ERP values at all tested sites and increased ΣWOV, ARGP function and neural activity, whereas APN injection into the GP reversed these changes. Mechanistically, APN treatment ameliorated the increased inflammatory response induced by RAP. In addition, the APN receptors AdipoR1 and AdipoR2 were detected both in neurons and in non-neuronal cells. Downstream of the AdipoRs, AMPK signaling was significantly activated and NF-κB signaling was significantly inhibited. More importantly, binding between APN and AdipoRs promoted macrophage phenotype switching from proinflammatory to anti-inflammatory. Figures Conclusion This study demonstrates that local administration of APN into atrial GP suppress RAP-induced AF by regulating the activity of the CANS. AMPK activation and macrophage phenotype switching may contribute to the attenuation of GP inflammation after APN injection. Therefore, APN signaling may provide a potential therapeutic target to AF.

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