scholarly journals A Case of Spondylodiscitis due to Bacteroides Fragilis in Febrile Patient With Past Thoracic Vertebral Trauma

2013 ◽  
Author(s):  
Ceriotti
Keyword(s):  
Bacteroides Fragilis ◽  
Febrile Patient ◽  
Vertebral Trauma

Morphologic alterations in bacteroides fragilis following single and combinant beta-lactam exposure

1986 ◽  
Vol 44 ◽  
pp. 304-305
Author(s):  
Michael P. Goheen ◽  
Charles E. Edmiston
Keyword(s):  
Bacteroides Fragilis ◽  
Synergistic Activity ◽  
Beta Lactam ◽  
Clinical Strains ◽  
Drug Activity ◽  
Obligate Anaerobic ◽  
Morphologic Changes

The synergistic activity of antimicrobial combinants against aerobic and facultative microorganisms has been well documented. in comparison, few studies have been performed using obligate anaerobic isolates and antimicrobial combinants. For this study clinical strains of Bacteroides fragilis(BF) were selected to investigate both single/combinant drug activity and cellular morphologic changes when BF is exposed to Imipenem (I), Piperacillin (P), Cefpimizole (C), Imipenem/Piperacillin (I+P), and Imipenem/Cefpimizole (I+C).

scholarly journals Association between colorectal cancer and Fusobacterium nucleatum and Bacteroides fragilis bacteria in Iranian patients: a preliminary study

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Aref Shariati ◽  
Shabnam Razavi ◽  
Ehsanollah Ghaznavi-Rad ◽  
Behnaz Jahanbin ◽  
Abolfazl Akbari ◽  
...  
Keyword(s):  
Colorectal Cancer ◽  
Relative Abundance ◽  
Normal Tissue ◽  
Bacteroides Fragilis ◽  
Fusobacterium Nucleatum ◽  
Normal Mucosa ◽  
Clinicopathologic Characteristics ◽  
Tissue Samples ◽  
Adjacent Normal Mucosa ◽  
Iranian Patients

Abstract Background and aim Recent studies have proposed that commensal bacteria might be involved in the development and progression of gastrointestinal disorders such as colorectal cancer (CRC). Therefore, in this study, the relative abundance of Fusobacterium nucleatum, Bacteroides fragilis, Streptococcus bovis/gallolyticus, and Enteropathogenic Escherichia coli (EPEC) in CRC tissues, and their association with clinicopathologic characteristics of CRC was investigated in Iranian patients. Moreover, the role of these bacteria in the CRC-associated mutations including PIK3CA, KRAS, and BRAF was studied. Method To these ends, the noted bacteria were quantified in paired tumors and normal tissue specimens of 30 CRC patients, by TaqMan quantitative Real-Time Polymerase Chain Reaction (qPCR). Next, possible correlations between clinicopathologic factors and mutations in PIK3CA, KRAS, and BRAF genes were analyzed. Results In studied samples, B. fragilis was the most abundant bacteria that was detected in 66 and 60% of paired tumor and normal samples, respectively. Furthermore, 15% of the B. fragilis-positive patients were infected with Enterotoxigenic B. fragilis (ETBF) in both adenocarcinoma and matched adjacent normal samples. F. nucleatum was also identified in 23% of tumors and 13% of adjacent normal tissue samples. Moreover, the relative abundance of these bacteria determined by 2-ΔCT was significantly higher in CRC samples than in adjacent normal mucosa (p < 0.05). On the other hand, our findings indicated that S. gallolyticus and EPEC, compared to adjacent normal mucosa, were not prevalent in CRC tissues. Finally, our results revealed a correlation between F. nucleatum-positive patients and the KRAS mutation (p = 0.02), while analyses did not show any association between bacteria and mutation in PIK3CA and BRAF genes. Conclusion The present study is the first report on the analysis of different bacteria in CRC tissue samples of Iranian patients. Our findings revealed that F. nucleatum and B. fragilis might be linked to CRC. However, any link between gut microbiome dysbiosis and CRC remains unknown.

The effect of β-lactam antibiotics on the growth curves of Bacteroides fragilis, obtained with the MS-2 system

1981 ◽  
Vol 8 (3) ◽  
pp. 219-224 ◽  
Author(s):  
E. Yourassowsky ◽  
M. P. Van der Linden ◽  
M. J. Lismont ◽  
M. Labbé ◽  
F. Crokaert
Keyword(s):  
Bacteroides Fragilis ◽  
Growth Curves
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