scholarly journals Soft Tissue Squamous Cell Carcinoma in Chest Wall with an Incomplete Border Sign

2011 ◽  
Author(s):  
Tatsuo Kimura
2020 ◽  
Vol 8 (9) ◽  
pp. 1618-1621 ◽  
Author(s):  
Dhiraj Mallik ◽  
Bina Ravi ◽  
Navin Kumar ◽  
Debarati Chattopadhyay ◽  
Anjum Syed ◽  
...  

2004 ◽  
Vol 124 (1) ◽  
pp. 97-101 ◽  
Author(s):  
James W. Moor ◽  
Jemy Jose ◽  
Colin Johnston ◽  
Andrew P. Coatesworth ◽  
Ken A. MacLennan

1993 ◽  
Vol 102 (3) ◽  
pp. 206-208 ◽  
Author(s):  
William W. Montgomery ◽  
Michael J. Samson ◽  
Mark A. Varvares ◽  
Max L. Goodman

The pectoralis major myocutaneous flap is a reliable regional flap commonly used for the reconstruction of head and neck defects. We report a case of a squamous cell carcinoma that occurred on the cutaneous paddle of a pectoralis flap in a patient with previous chest wall lesions. The need for a careful history of previous chest wall cutaneous lesions is stressed in patients who are to undergo this type of reconstruction.


Cancers ◽  
2020 ◽  
Vol 12 (6) ◽  
pp. 1474 ◽  
Author(s):  
Victor M. Baart ◽  
Chayenne van Duijn ◽  
Sylvia L. van Egmond ◽  
Willem A. Dijckmeester ◽  
Jeroen C. Jansen ◽  
...  

R0 resection is paramount in cutaneous squamous cell carcinoma (CSCC) and head and neck squamous cell carcinoma (HNSCC). However, in the setting of recurrence, immunocompromised patients, or non-keratinizing squamous cell carcinoma (SCC) with a spindle growth pattern, tumor borders are difficult, if not impossible, to determine. Fluorescence-guided surgery (FGS) aids in this differentiation. Potential targets for FGS of CSCC and HNSCC were evaluated. Most sections stained intensely for αvβ6 and epidermal growth factor receptor (EGFR) on tumor cells. Normal epithelium stained less for αvβ6 than for EGFR. In addition, soft tissue and stroma stained negative for both, allowing for clear discrimination of the soft tissue margin. Tumor cells weakly expressed urokinase plasminogen activator receptor (uPAR) while expression on stromal cells was moderate. Normal epithelium rarely expressed uPAR, resulting in clear discrimination of superficial margins. Tumors did not consistently express integrin β3, carcinoembryonic antigen, epithelial cell adhesion molecule, or vascular endothelial growth factor A. In conclusion, αvβ6 and EGFR allowed for precise discrimination of SSC at the surgically problematic soft tissue margins. Superficial margins are ideally distinguished with uPAR. In the future, FGS in the surgically challenging setting of cutaneous and mucosal SCC could benefit from a tailor-made approach, with EGFR and αvβ6 as targets.


2017 ◽  
Vol 43 (4) ◽  
pp. 291-296 ◽  
Author(s):  
Fabio Bernardello ◽  
Giampietro Bertasi ◽  
Ralph Powers ◽  
Sergio Spinato ◽  
Andrea Viaggi ◽  
...  

Many dental procedures allow for implant placement in partially or totally edentulous patients. Despite the availability of various implant and abutment types on the market, it often becomes quite challenging to achieve the biological and esthetic goals in a patient who has ridge deficiencies. Problems arise from the lack of adequate bone quality and quantity.1,2 Soft tissue form and maintenance is also a consideration to evaluate.3 Primary reconstructive techniques following segmental mandibulectomy is evolving and improves quality of life. A seldom encountered complication is the discovery and treatment of a malignant process (for example, squamous cell carcinoma). Oral squamous cell carcinoma (OSCC) is one of the most aggressive malignancies worldwide and accounts for more than 90% of all oral cancers.4 It is ranked as the sixth leading cause of cancer mortality worldwide. The most common sites of OSCC are the lateral ventral surface of the tongue, the floor of the mouth and buccal mucosa. For most oral cavity cancers, surgery is the initial treatment of choice (often involving the full or partial removal of bony jaw structure).5 Radiation or chemoradiation is added postoperatively if disease is more advanced or has high-risk features. Successful cancer therapy can affect the quantity and quality of soft tissue in areas where implants are planned, thus affecting the initial placement and the long-term success of the implants. Complications can be numerous; especially difficult is implant treatment in the mandibular anterior area where inadequate alveolar height results in the lingual floor and the vestibule becoming contiguous.6 Further complicating treatment is the presence of scar tissue (often found following cancer surgery and radiotherapy). The present case is a report of the combination of a soft tissue enhancement and implant placement following partial mandibulectomy resulting from the treatment of oral squamous cell carcinoma. A video abstract is available for viewing at https://youtu.be/dZ9t3j4ufOc?list=PLvRxNhB9EJqbqjcYMbwKbwi8Xpbb0YuHI.


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