scholarly journals Depressed Exercise Peak Ejection Rate Detected on Ambulatory Radionuclide Monitoring Reflects End-Stage Cardiac Inotropic Reserve and Predicts Mortality in Ischaemic Cardiomyopathy

2012 ◽  
Author(s):  
Carboni
Keyword(s):  
Ischaemic Cardiomyopathy ◽  
Ejection Rate ◽  
Peak Ejection Rate ◽  
End Stage

Beurteilung der Adriamycin-Kardiotoxizität mittels der Äquilibrium-Radionuklid-Ventrikulographie

1987 ◽  
Vol 26 (05) ◽  
pp. 206-211 ◽  
Author(s):  
P. Knesewitsch ◽  
N. H. Göldel ◽  
S. Fritsch ◽  
E. Moser
Keyword(s):  
Left Ventricular ◽  
Peak Filling Rate ◽  
Base System ◽  
Filling Rate ◽  
Time To Peak ◽  
Ejection Rate ◽  
Follow Up Studies ◽  
Pathologic Findings ◽  
Peak Ejection Rate

Results of 606 equilibrium radionuclide ventriculographies (ERNV) performed in 348 non-selected patients receiving Adriamycin (ADM) therapy were stored in a data base system. The aim of the study was to assess the influence of a potential cardiotoxic therapy on left ventricular pump function. Increasing ADM doses yielded a significant (p <0.05) decrease of the resting ejection fraction (R-gEF), the peak ejection rate and the peak filling rate. Enddiastolic and endsystolic volumes increased significantly. Stroke volume, heart rate and time to peak filling rate did not change significantly. 368 follow-up studies were performed in 128 patients: 65/128 patients presented a decrease of R-gEF, but only in 45 of these patients R-gEF values fell into the pathologic range. In 44 of these follow-ups, R-gEF remained unchanged. In 19 patients, a R-gEF increase was observed. At the beginning of ADM therapy 14% of the patients had subnormal R-gEF values. With increasing ADM doses pathologic findings increased to 86% in patients with ADM doses higher than 500 mg/m2.

scholarly journals Less invasive ventricular enhancement (LIVE) as potential therapy for ischaemic cardiomyopathy end-stage heart failure

2019 ◽  
Vol 11 (S6) ◽  
pp. S921-S928 ◽  
Author(s):  
Antonio Loforte ◽  
Jacopo Alfonsi ◽  
Gregorio Gliozzi ◽  
Gianluca Folesani ◽  
Mariafrancesca Fiorentino ◽  
...  
Keyword(s):  
Heart Failure ◽  
Less Invasive ◽  
Ischaemic Cardiomyopathy ◽  
End Stage Heart Failure ◽  
End Stage

HLA antigen frequencies in end-stage idiopathic and ischaemic cardiomyopathy

1999 ◽  
Vol 68 (1) ◽  
pp. 31-37 ◽  
Author(s):  
A.A Harcombe ◽  
L Sharples ◽  
S.R Large ◽  
J Wallwork ◽  
P.L Weissberg ◽  
...  
Keyword(s):  
Hla Antigen ◽  
Ischaemic Cardiomyopathy ◽  
End Stage

Echocardiographic assessment of left ventricular function at rest and during exercise in postoperative patients with tetralogy of Fallot

1994 ◽  
Vol 4 (3) ◽  
pp. 267-276 ◽  
Author(s):  
Gunnar Norgård ◽  
Kai Andersen ◽  
Harald Vik-Mo
Keyword(s):  
Left Ventricular Function ◽  
Ventricular Function ◽  
Exercise Test ◽  
Healthy Subjects ◽  
Left Ventricular ◽  
Peak Filling Rate ◽  
Filling Rate ◽  
Ejection Rate ◽  
Peak Ejection Rate ◽  
Fractional Shortening

AbstractDigitized M-mode echocardiograms of left ventricular function were obtained in 34 patients subsequent to surgical repair of tetralogy of Fallot and in 34 healthy subjects at rest. In 16 patients and 16 controls, studies were also made during submaximal semisupine bicycle exercise. At rest, the peak ejection rate and fractional shortening were slightly reduced in the patients, whereas peak filling rate was comparable in patients and controls. Pulmonary regurgitation did not seem to influence left ventricular function. During exercise, however, peak filling rate was reduced in the patients compared to the healthy subjects. At peak exercise, the peak filling rates were 27.8±6.3 cm•s−1 and 34.1±3.4 cm•s−1 in patients and controls, respectively (p<0.01). No differences were found in heart rate, fractional shortening, peak ejection rate or blood pressures between patients and controls throughout the exercise test. When the subjects were subdivided by median age, the oldest patients had reduced normalized peak filling rates throughout the exercise test, whereas no differences were found between younger and older healthy subjects. Thus, it is suggested that the reduced left ventricular peak filling rate found during exercise is caused by subclinical myocardial dysfunction which seems to be related to myocardial protection at surgery and the period of follow-up.

Dual-chamber pacing in patients with end-stage ischaemic cardiomyopathy

The Lancet ◽  
1993 ◽  
Vol 341 (8859) ◽  
pp. 1543 ◽  
Author(s):  
Margarete Hochleitner ◽  
Helmut Hörtnagl ◽  
Franz Gschnitzer
Keyword(s):  
Dual Chamber ◽  
Dual Chamber Pacing ◽  
Ischaemic Cardiomyopathy ◽  
End Stage

scholarly journals Central hemodynamic effects in patients with chronic coronary syndrome after long-term ivabradine therapy

2020 ◽  
Vol 41 (Supplement_2) ◽  
Author(s):  
A.L Hohneck ◽  
P Fries ◽  
J Stroeder ◽  
G Schneider ◽  
S.H Schirmer ◽  
...  
Keyword(s):  
Aortic Distensibility ◽  
Aortic Flow ◽  
Lv Function ◽  
Filling Rate ◽  
Mean Velocity ◽  
Coronary Syndrome ◽  
Ejection Rate ◽  
Central Hemodynamic ◽  
Peak Ejection Rate

Abstract Objectives We sought to assess central hemodynamic effects in 23 patients (18 male, 5 female) with a resting heart rate (HR) of ≥70 beats per minute (bpm) and chronic coronary syndrome after long-term ivabradine therapy (6 months) by cardiac magnetic resonance (CMR). Methods and results In a cross-over design, all patients were treated with ivabradine (Iva, 7.5 mg bid) and placebo for 6 months each. CMR was performed three times (at baseline, after 6 and 12 months) to determine left ventricular (LV) function parameters, including end-diastolic and end-systolic volumes (EDVi, ESVi), stroke volume (SVi) and ejection fraction (EF) as well as volume-time curve (VTC) parameters, including peak ejection rate (PER), peak ejection time (PET), peak filling rate (PFR), peak filling time from ES (PFT), peak ejection rate normalized to EDV (PER/EDV) and peak filling rate normalized to EDV (PFR/EDV) for global LV function (systolic and diastolic) assessment. Flow measurements of the ascending aorta were performed with phase-contrast velocity imaging. Treatment with Iva led to a HR reduction of 11.4 bpm (Iva 58.8±8.2 bpm vs placebo 70.2±8.3 bpm, p&lt;0.0001).There was no difference in LVEF (%) (Iva 57.4±11.2 vs placebo 53.0±10.9, p=0.18), EDVi or ESVi. SVi (ml/m2) remained comparatively unchanged after long-term treatment with Iva (Iva 40.6±9.6 vs placebo 35.7±8.8, p=0.08). VTC parameters reflecting systolic LV function (PER, PET) were unaffected by Iva, while both PFR and PFR/EDV were significantly increased (PFR/EDV (s-1) Iva 2.4±0.4 vs placebo 2.1±0.4, p=0.03). There was a trend to longer PFT during treatment with Iva, though not reaching statistical significance. Medium and maximum aortic flow were not affected by treatment with Iva, while mean velocity (cm/s) was significantly reduced (Iva 6.7±2.7 vs placebo 9.0±3.4, p=0.01). Aortic flow parameters were correlated to aortic distensibility (AD), as surrogate parameter for arterial stiffness. AD was significantly correlated to both aortic flow and flow velocity, whereby mean velocity showed the strongest correlation to AD (r=0.74 [0.61 to 0.83], p&lt;0.0001). Conclusion Systolic LV function was unaffected by treatment with Iva, while the filling during diastole was significantly improved. While medium and maximum aortic flow were not affected by Iva, mean velocity was significantly reduced. Aortic distensibility as surrogate parameter for arterial stiffness was significantly correlated to aortic mean velocity. This study confirms the underlying physiological principle of the If-current inhibitor Ivabradine. Funding Acknowledgement Type of funding source: Public Institution(s). Main funding source(s): This work was supported by the Deutsche Herzstiftung (German Heart Foundation) (F/14/11 to F.C.) and the Deutsche Forschungsgemeinschaft (DFG KFO 196 to U.L., S.H.S and M.B. and SFB TTR 219, S-01 to M.B.). The Saarland University Medical Center has received an unrestricted grant from Servier (France).

Beurteilung der Adriamycin- Kardiotoxizität mittels der Äquilibrium-Radionuklid- Ventrikulographie

1987 ◽  
Vol 26 (05) ◽  
pp. 212-219
Author(s):  
N. H. Göldel ◽  
S. Fritsch ◽  
E. Moser ◽  
P. Knesewitsch
Keyword(s):  
Early Detection ◽  
Malignant Tumors ◽  
Left Ventricular ◽  
Peak Filling Rate ◽  
Filling Rate ◽  
Global Ejection Fraction ◽  
Time To Peak ◽  
Ejection Rate ◽  
Peak Ejection Rate ◽  
Higher Sensitivity

The aim of the study was to evaluate the influence of a cardiotoxic therapy with Adriamycin (ADM) on left ventricular pump function. In 348 patients with malignant tumors, 606 equilibrium radionuclide ventriculographies (ERNV) were performed. In 90 patients, resting studies (R-ERNV) were followed by studies during exercise (E-ERNV). Results were evaluated statistically to determine whether E-ERNV provides more reliable parameters in the early detection of Adriamycin cardiomyopathy (ADM-CMP) than R-ERNV. The following left ventricular parameters were evaluated: global ejection fraction (gEF); enddiastolic, endsystolic, stroke volume (EDV, ESV, SV); peak filling rate, peak ejection rate (pFR, pER); time to peak filling rate (TpFR) and heart rate. Increasing ADM doses yielded a significant decrease (p <0.05) of resting values of gEF, pER, pFR. In contrast, stress-induced increases of gEF, pER, pFR were found independent of accumulative ADM doses and independent of the resting values of these parameters. An increase of gEF resulted from a significant decrease of ESV. In most cases, pathologic results at rest were detected earlier than subnormal changes of exercise values. Therefore, E-ERNV does not have a significantly higher sensitivity in the early detection of ADM-CMP than R-ERNV and is not required for the surveillance of patients under ADM therapy.

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