Performance Analysis of Microarray Data Classification using Machine Learning Techniques

2015 ◽  
Vol 5 (2) ◽  
pp. 43-54
Author(s):  
Subhendu Kumar Pani ◽  
Bikram Kesari Ratha ◽  
Ajay Kumar Mishra
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Microarray Data ◽  
Predictive Accuracy ◽  
Machine Learning Techniques ◽  
Learning Approaches ◽  
Data Mining Technique ◽  
Single Experiment ◽  
Learning Techniques ◽  
Microarray Datasets

Microarray technology of DNA permits simultaneous monitoring and determining of thousands of gene expression activation levels in a single experiment. Data mining technique such as classification is extensively used on microarray data for medical diagnosis and gene analysis. However, high dimensionality of the data affects the performance of classification and prediction. Consequently, a key issue in microarray data is feature selection and dimensionality reduction in order to achieve better classification and predictive accuracy. There are several machine learning approaches available for feature selection. In this study, the authors use Particle Swarm Organization (PSO) and Genetic Algorithm (GA) to find the performance of several popular classifiers on a set of microarray datasets. Experimental results conclude that feature selection affects the performance.

scholarly journals Machine Learning Frameworks in Cancer Detection

2021 ◽  
Vol 297 ◽  
pp. 01073
Author(s):  
Sabyasachi Pramanik ◽  
K. Martin Sagayam ◽  
Om Prakash Jena
Keyword(s):  
Machine Learning ◽  
Prediction Models ◽  
Supervised Machine Learning ◽  
Machine Learning Techniques ◽  
Cancer Development ◽  
Support Vector ◽  
Learning Approaches ◽  
Learning Techniques ◽  
Fact Finding ◽  
Risk Of Cancer

Cancer has been described as a diverse illness with several distinct subtypes that may occur simultaneously. As a result, early detection and forecast of cancer types have graced essentially in cancer fact-finding methods since they may help to improve the clinical treatment of cancer survivors. The significance of categorizing cancer suffers into higher or lower-threat categories has prompted numerous fact-finding associates from the bioscience and genomics field to investigate the utilization of machine learning (ML) algorithms in cancer diagnosis and treatment. Because of this, these methods have been used with the goal of simulating the development and treatment of malignant diseases in humans. Furthermore, the capacity of machine learning techniques to identify important characteristics from complicated datasets demonstrates the significance of these technologies. These technologies include Bayesian networks and artificial neural networks, along with a number of other approaches. Decision Trees and Support Vector Machines which have already been extensively used in cancer research for the creation of predictive models, also lead to accurate decision making. The application of machine learning techniques may undoubtedly enhance our knowledge of cancer development; nevertheless, a sufficient degree of validation is required before these approaches can be considered for use in daily clinical practice. An overview of current machine learning approaches utilized in the simulation of cancer development is presented in this paper. All of the supervised machine learning approaches described here, along with a variety of input characteristics and data samples, are used to build the prediction models. In light of the increasing trend towards the use of machine learning methods in biomedical research, we offer the most current papers that have used these approaches to predict risk of cancer or patient outcomes in order to better understand cancer.

scholarly journals Evolutionary Machine Learning for Classification with Incomplete Data

2021 ◽  
Author(s):  
◽  
Cao Truong Tran
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Genetic Programming ◽  
Incomplete Data ◽  
Missing Values ◽  
Machine Learning Techniques ◽  
Feature Construction ◽  
Classification Algorithms ◽  
Learning Techniques ◽  
Effectiveness And Efficiency

<p>Classification is a major task in machine learning and data mining. Many real-world datasets suffer from the unavoidable issue of missing values. Classification with incomplete data has to be carefully handled because inadequate treatment of missing values will cause large classification errors.    Existing most researchers working on classification with incomplete data focused on improving the effectiveness, but did not adequately address the issue of the efficiency of applying the classifiers to classify unseen instances, which is much more important than the act of creating classifiers. A common approach to classification with incomplete data is to use imputation methods to replace missing values with plausible values before building classifiers and classifying unseen instances. This approach provides complete data which can be then used by any classification algorithm, but sophisticated imputation methods are usually computationally intensive, especially for the application process of classification. Another approach to classification with incomplete data is to build a classifier that can directly work with missing values. This approach does not require time for estimating missing values, but it often generates inaccurate and complex classifiers when faced with numerous missing values. A recent approach to classification with incomplete data which also avoids estimating missing values is to build a set of classifiers which then is used to select applicable classifiers for classifying unseen instances. However, this approach is also often inaccurate and takes a long time to find applicable classifiers when faced with numerous missing values.   The overall goal of the thesis is to simultaneously improve the effectiveness and efficiency of classification with incomplete data by using evolutionary machine learning techniques for feature selection, clustering, ensemble learning, feature construction and constructing classifiers.   The thesis develops approaches for improving imputation for classification with incomplete data by integrating clustering and feature selection with imputation. The approaches improve both the effectiveness and the efficiency of using imputation for classification with incomplete data.   The thesis develops wrapper-based feature selection methods to improve input space for classification algorithms that are able to work directly with incomplete data. The methods not only improve the classification accuracy, but also reduce the complexity of classifiers able to work directly with incomplete data.   The thesis develops a feature construction method to improve input space for classification algorithms with incomplete data by proposing interval genetic programming-genetic programming with a set of interval functions. The method improves the classification accuracy and reduces the complexity of classifiers.   The thesis develops an ensemble approach to classification with incomplete data by integrating imputation, feature selection, and ensemble learning. The results show that the approach is more accurate, and faster than previous common methods for classification with incomplete data.   The thesis develops interval genetic programming to directly evolve classifiers for incomplete data. The results show that classifiers generated by interval genetic programming can be more effective and efficient than classifiers generated the combination of imputation and traditional genetic programming. Interval genetic programming is also more effective than common classification algorithms able to work directly with incomplete data.    In summary, the thesis develops a range of approaches for simultaneously improving the effectiveness and efficiency of classification with incomplete data by using a range of evolutionary machine learning techniques.</p>

scholarly journals Machine learning for metagenomics: methods and tools

Metagenomics ◽  
2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Hayssam Soueidan ◽  
Macha Nikolski
Keyword(s):  
Machine Learning ◽  
Gene Prediction ◽  
Full Range ◽  
Machine Learning Techniques ◽  
Learning Approaches ◽  
Unified Framework ◽  
Comparative Metagenomics ◽  
Learning Techniques ◽  
Ngs Data ◽  
Modern Machine

AbstractOwing to the complexity and variability of metagenomic studies, modern machine learning approaches have seen increased usage to answer a variety of question encompassing the full range of metagenomic NGS data analysis.We review here the contribution of machine learning techniques for the field of metagenomics, by presenting known successful approaches in a unified framework. This review focuses on five important metagenomic problems:OTU-clustering, binning, taxonomic proffiing and assignment, comparative metagenomics and gene prediction. For each of these problems, we identify the most prominent methods, summarize the machine learning approaches used and put them into perspective of similar methods.We conclude our review looking further ahead at the challenge posed by the analysis of interactions within microbial communities and different environments, in a field one could call “integrative metagenomics”.

Analysis of Kinase Inhibitors and Druggability of Kinase-Targets Using Machine Learning Techniques

2012 ◽  
pp. 155-165
Author(s):  
S. Prasanthi ◽  
S.Durga Bhavani ◽  
T. Sobha Rani ◽  
Raju S. Bapi
Keyword(s):  
Machine Learning ◽  
Decision Tree ◽  
Kinase Inhibitors ◽  
Kinase Inhibitor ◽  
Classification Problem ◽  
Machine Learning Techniques ◽  
Learning Approaches ◽  
Decision Tree Classifier ◽  
Data Set ◽  
Learning Techniques

Vast majority of successful drugs or inhibitors achieve their activity by binding to, and modifying the activity of a protein leading to the concept of druggability. A target protein is druggable if it has the potential to bind the drug-like molecules. Hence kinase inhibitors need to be studied to understand the specificity of a kinase inhibitor in choosing a particular kinase target. In this paper we focus on human kinase drug target sequences since kinases are known to be potential drug targets. Also we do a preliminary analysis of kinase inhibitors in order to study the problem in the protein-ligand space in future. The identification of druggable kinases is treated as a classification problem in which druggable kinases are taken as positive data set and non-druggable kinases are chosen as negative data set. The classification problem is addressed using machine learning techniques like support vector machine (SVM) and decision tree (DT) and using sequence-specific features. One of the challenges of this classification problem is due to the unbalanced data with only 48 druggable kinases available against 509 non-drugggable kinases present at Uniprot. The accuracy of the decision tree classifier obtained is 57.65 which is not satisfactory. A two-tier architecture of decision trees is carefully designed such that recognition on the non-druggable dataset also gets improved. Thus the overall model is shown to achieve a final performance accuracy of 88.37. To the best of our knowledge, kinase druggability prediction using machine learning approaches has not been reported in literature.

Overview of Machine Learning Approaches for Wireless Communication

2021 ◽  
pp. 1579-1597
Author(s):  
Tolga Ensari ◽  
Melike Günay ◽  
Yağız Nalçakan ◽  
Eyyüp Yildiz
Keyword(s):  
Machine Learning ◽  
Wireless Communications ◽  
Smart Phones ◽  
Machine Learning Techniques ◽  
Learning Approaches ◽  
Research Areas ◽  
Learning Techniques ◽  
Recent Developments ◽  
Security And Reliability ◽  
Day By Day

Machine learning is one of the most popular research areas, and it is commonly used in wireless communications and networks. Security and fast communication are among of the key requirements for next generation wireless networks. Machine learning techniques are getting more important day-by-day since the types, amount, and structure of data is continuously changing. Recent developments in smart phones and other devices like drones, wearable devices, machines with sensors need reliable communication within internet of things (IoT) systems. For this purpose, artificial intelligence can increase the security and reliability and manage the data that is generated by the wireless systems. In this chapter, the authors investigate several machine learning techniques for wireless communications including deep learning, which represents a branch of artificial neural networks.

scholarly journals Non-Intrusive Load Monitoring of Residential Water-Heating Circuit Using Ensemble Machine Learning Techniques

Inventions ◽  
2020 ◽  
Vol 5 (4) ◽  
pp. 57
Author(s):  
Attique Ur Rehman ◽  
Tek Tjing Lie ◽  
Brice Vallès ◽  
Shafiqur Rahman Tito
Keyword(s):  
Machine Learning ◽  
Feature Selection ◽  
Machine Learning Techniques ◽  
Learning Models ◽  
Water Heating ◽  
Energy Monitoring ◽  
Non Invasive ◽  
Ensemble Machine Learning ◽  
Learning Techniques ◽  
Load Monitoring

The recent advancement in computational capabilities and deployment of smart meters have caused non-intrusive load monitoring to revive itself as one of the promising techniques of energy monitoring. Toward effective energy monitoring, this paper presents a non-invasive load inference approach assisted by feature selection and ensemble machine learning techniques. For evaluation and validation purposes of the proposed approach, one of the major residential load elements having solid potential toward energy efficiency applications, i.e., water heating, is considered. Moreover, to realize the real-life deployment, digital simulations are carried out on low-sampling real-world load measurements: New Zealand GREEN Grid Database. For said purposes, MATLAB and Python (Scikit-Learn) are used as simulation tools. The employed learning models, i.e., standalone and ensemble, are trained on a single household’s load data and later tested rigorously on a set of diverse households’ load data, to validate the generalization capability of the employed models. This paper presents a comprehensive performance evaluation of the presented approach in the context of event detection, feature selection, and learning models. Based on the presented study and corresponding analysis of the results, it is concluded that the proposed approach generalizes well to the unseen testing data and yields promising results in terms of non-invasive load inference.

scholarly journals A Machine Learning View on Momentum and Reversal Trading

Algorithms ◽  
2018 ◽  
Vol 11 (11) ◽  
pp. 170 ◽  
Author(s):  
Zhixi Li ◽  
Vincent Tam
Keyword(s):  
Neural Network ◽  
Machine Learning ◽  
Stock Market ◽  
Short Term Memory ◽  
Predictive Ability ◽  
Trading Strategies ◽  
Machine Learning Techniques ◽  
Support Vector ◽  
Learning Approaches ◽  
Learning Techniques

Momentum and reversal effects are important phenomena in stock markets. In academia, relevant studies have been conducted for years. Researchers have attempted to analyze these phenomena using statistical methods and to give some plausible explanations. However, those explanations are sometimes unconvincing. Furthermore, it is very difficult to transfer the findings of these studies to real-world investment trading strategies due to the lack of predictive ability. This paper represents the first attempt to adopt machine learning techniques for investigating the momentum and reversal effects occurring in any stock market. In the study, various machine learning techniques, including the Decision Tree (DT), Support Vector Machine (SVM), Multilayer Perceptron Neural Network (MLP), and Long Short-Term Memory Neural Network (LSTM) were explored and compared carefully. Several models built on these machine learning approaches were used to predict the momentum or reversal effect on the stock market of mainland China, thus allowing investors to build corresponding trading strategies. The experimental results demonstrated that these machine learning approaches, especially the SVM, are beneficial for capturing the relevant momentum and reversal effects, and possibly building profitable trading strategies. Moreover, we propose the corresponding trading strategies in terms of market states to acquire the best investment returns.

Homeland Security Data Mining and Link Analysis

2011 ◽  
pp. 566-569
Author(s):  
Bhavani Thuraisingham
Keyword(s):  
Machine Learning ◽  
Data Mining ◽  
Homeland Security ◽  
Link Analysis ◽  
Machine Learning Techniques ◽  
Data Mining Technique ◽  
Learning Techniques ◽  
Terrorist Groups ◽  
Using Data ◽  
Terrorist Events

Data mining is the process of posing queries to large quantities of data and extracting information often previously unknown using mathematical, statistical, and machine-learning techniques. Data mining has many applications in a number of areas, including marketing and sales, medicine, law, manufacturing, and, more recently, homeland security. Using data mining, one can uncover hidden dependencies between terrorist groups as well as possibly predict terrorist events based on past experience. One particular data-mining technique that is being investigated a great deal for homeland security is link analysis, where links are drawn between various nodes, possibly detecting some hidden links.

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