Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance

SciVee ◽  
2012 ◽  
Author(s):  
Lovisa Johansson ◽  
Anders Danielsson ◽  
Hemang Parikh ◽  
Maria Klintenberg ◽  
Fredrik Norström ◽  
...  
Keyword(s):  
Gene Expression ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Differential Gene Expression ◽  
Human Subjects ◽  
Weight Maintenance ◽  
Differential Gene ◽  
Obese Human

scholarly journals Differential gene expression in adipose tissue from obese human subjects during weight loss and weight maintenance

2012 ◽  
Vol 96 (1) ◽  
pp. 196-207 ◽  
Author(s):  
Lovisa E Johansson ◽  
Anders PH Danielsson ◽  
Hemang Parikh ◽  
Maria Klintenberg ◽  
Fredrik Norström ◽  
...  
Keyword(s):  
Gene Expression ◽  
Weight Loss ◽  
Adipose Tissue ◽  
Differential Gene Expression ◽  
Human Subjects ◽  
Weight Maintenance ◽  
Differential Gene ◽  
Obese Human

Differential gene expression indicates that ‘buffalo hump’ is a distinct adipose tissue disturbance in HIV-1-associated lipodystrophy

AIDS ◽  
2008 ◽  
Vol 22 (5) ◽  
pp. 575-584 ◽  
Author(s):  
Jordi P Guallar ◽  
José M Gallego-Escuredo ◽  
Joan C Domingo ◽  
Marta Alegre ◽  
Joan Fontdevila ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Differential Gene Expression ◽  
Differential Gene ◽  
Buffalo Hump ◽  
Hiv 1

scholarly journals Trans-fatty acids aggravate anabolic steroid-induced metabolic disturbances and differential gene expression in muscle, pancreas and adipose tissue

Life Sciences ◽  
2019 ◽  
Vol 232 ◽  
pp. 116603 ◽  
Author(s):  
Reggiani V. Gonçalves ◽  
Jamili D.B. Santos ◽  
Natanny S. Silva ◽  
Etienne Guillocheau ◽  
Robson E. Silva ◽  
...  
Keyword(s):  
Gene Expression ◽  
Fatty Acids ◽  
Adipose Tissue ◽  
Differential Gene Expression ◽  
Anabolic Steroid ◽  
Trans Fatty Acids ◽  
Metabolic Disturbances ◽  
Differential Gene

scholarly journals Differential gene expression of insulin receptor isoforms A and B and insulin receptor substrates 1, 2 and 3 in rat tissues: modulation by aging and differentiation in rat adipose tissue

2005 ◽  
Vol 34 (1) ◽  
pp. 153-161 ◽  
Author(s):  
R Serrano ◽  
M Villar ◽  
C Martínez ◽  
J M Carrascosa ◽  
N Gallardo ◽  
...  
Keyword(s):  
Gene Expression ◽  
Insulin Resistance ◽  
Adipose Tissue ◽  
Insulin Receptor ◽  
Differential Gene Expression ◽  
Target Tissue ◽  
Insulin Receptor Isoforms ◽  
Alternatively Spliced ◽  
Differential Gene ◽  
Exon 11

The insulin receptor (IR) occurs as two alternatively spliced isoforms, IR-A (exon 11−) and IR-B (exon 11+), which exhibit functional differences and are expressed in a tissue-specific manner. The IR substrate (IRS) proteins 1, 2 and 3 also differ in function and tissue distribution. Here we show the differential gene expression of IRs and IRSs in several rat target tissues of insulin action. IR-B is significantly higher than IR-A in epididymal white adipose tissue and adipogenesis induces a shift in the alternatively spliced species of IR from the A to the B isoform. Moreover, since aging in the rat is associated with the development of insulin resistance we looked for alterations of expression of these proteins in adipocytes from old rats. Our results reveal that there is a specific decrease in the expression of the IR-B isoform, as well as both mRNA and protein levels of IR, IRS-1 and IRS-3 being significantly decreased, in epididymal adipose tissue from old compared with adult rats. It is concluded that the down-regulation of early components of the insulin transduction pathway in a primary insulin target tissue could be related to the insulin resistance of aging.

Detection of differential gene expression in brown adipose tissue of hibernating arctic ground squirrels with mouse microarrays

2006 ◽  
Vol 25 (2) ◽  
pp. 346-353 ◽  
Author(s):  
Jun Yan ◽  
Adlai Burman ◽  
Calen Nichols ◽  
Linda Alila ◽  
Louise C. Showe ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Brown Adipose Tissue ◽  
Differential Gene Expression ◽  
Differentially Expressed Genes ◽  
Ground Squirrels ◽  
Nonshivering Thermogenesis ◽  
Brown Adipose ◽  
Differential Gene ◽  
Arctic Ground Squirrels

Hibernation is an energy-saving strategy adopted by a wide range of mammals to survive highly seasonal or unpredictable environments. Arctic ground squirrels living in Alaska provide an extreme example, with 6- to 9-mo-long hibernation seasons when body temperature alternates between levels near 0°C during torpor and 37°C during arousal episodes. Heat production during hibernation is provided, in part, by nonshivering thermogenesis that occurs in large deposits of brown adipose tissue (BAT). BAT is active at tissue temperatures from 0 to 37°C during rewarming and continuously at near 0°C during torpor in subfreezing conditions. Despite its crucial role in hibernation, the global gene expression patterns in BAT during hibernation compared with the nonhibernation season remain largely unknown. We report a large-scale study of differential gene expression in BAT between winter hibernating and summer active arctic ground squirrels using mouse microarrays. Selected differentially expressed genes identified on the arrays were validated by quantitative real-time PCR using ground squirrel specific primers. Our results show that the mRNA levels of the genes involved in nearly every step of the biochemical pathway leading to nonshivering thermogenesis are significantly increased in BAT during hibernation, whereas those of genes involved in protein biosynthesis are significantly decreased compared with summer active animals in August. Surprisingly, the differentially expressed genes also include adipocyte differentiation-related protein or adipophilin ( Adfp), gap junction protein 1 ( Gja1), and secreted protein acidic and cysteine-rich ( Sparc), which may play a role in enhancing thermogenesis at low tissue temperatures in BAT.

Obesity-related Differential Gene Expression in the Visceral Adipose Tissue

2005 ◽  
Vol 15 (6) ◽  
pp. 758-765 ◽  
Author(s):  
Ancha Baranova ◽  
Rochelle Collantes ◽  
Shobha J. Gowder ◽  
Hazem Elariny ◽  
Karen Schlauch ◽  
...  
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Differential Gene Expression ◽  
Visceral Adipose Tissue ◽  
Differential Gene ◽  
Visceral Adipose

Differential Gene Expression in Liposarcoma, Lipoma, and Adipose Tissue

2005 ◽  
Vol 23 (2) ◽  
pp. 101-114 ◽  
Author(s):  
Keith M Skubitz ◽  
Edward Y Cheng ◽  
Denis R Clohisy ◽  
Roby C Thompson ◽  
Amy P. N Skubitz
Keyword(s):  
Gene Expression ◽  
Adipose Tissue ◽  
Differential Gene Expression ◽  
Differential Gene
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